KEGG ENZYME: 2.1.1.361

ENZYME: 2.1.1.361

Entry

EC 2.1.1.361                Enzyme

Name

[histone H4]-lysine20 N-methyltransferase;
KMT5A (gene name);
SET8 (gene name);
PR-SET7 (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20

Reaction(KEGG)

(other) R03875

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-L-lysine20

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6-methyl-L-lysine20

Comment

The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.

History

EC 2.1.1.361 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.361

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K11428

[histone H4]-lysine20 N-methyltransferase SETD8

K20795

[histone H4]-lysine20 N-methyltransferase PRDM6

Genes

HSA:	387893(KMT5A) 93166(PRDM6)

PTR:	452343(KMT5A) 742318(PRDM6)

PPS:	100978154 100982491(PRDM6) 100986737(KMT5A) 117978852

GGO:	101143097(PRDM6) 101145513(KMT5A)

PON:	100451760(KMT5A) 100460132(PRDM6)

NLE:	100579681(PRDM6) 100580339(KMT5A)

HMH:	116470339(PRDM6) 116477743(KMT5A)

MCC:	703499(PRDM6) 709345(KMT5A)

MCF:	102128021(KMT5A) 102142246(PRDM6)

MTHB:

126930652 126957524

MNI:	105463145(PRDM6) 105494001(KMT5A)

CSAB:

103239328(KMT5A) 103244427(PRDM6)

CATY:

105591004(SETD8) 105599677(PRDM6)

PANU:

101010043(KMT5A) 101014277(PRDM6)

TGE:	112625690(PRDM6) 112635259(KMT5A)

MLEU:

105528012(SETD8) 105545038(PRDM6)

RRO:	104660930(PRDM6) 104666320(KMT5A)

RBB:	108520391(PRDM6) 108540752(KMT5A)

TFN:	117065954(PRDM6) 117080344 117089217(KMT5A)

PTEH:

111527675(PRDM6) 111538508 111539563

CANG:

105516385(SETD8) 105526098 105527423(PRDM6)

CJC:	100411011(PRDM6) 100414548(KMT5A)

SBQ:	101040690(SETD8) 101047827(PRDM6)

CIMI:

108294847 108306767(PRDM6) 108315116(KMT5A)

CSYR:

103271959(KMT5A) 103275779(PRDM6)

MMUR:

105880868(KMT5A) 105884549(PRDM6)

LCAT:

123626118(KMT5A) 123648463(PRDM6)

PCOQ:

105825686(SETD8) 105826327(PRDM6)

OGA:	100940536(KMT5A) 100963252(PRDM6)

MMU:	225518(Prdm6) 67956(Kmt5a)

MCAL:

110284774(Prdm6) 110295130(Kmt5a)

MPAH:

110312821(Kmt5a) 110333293(Prdm6)

RNO:	100361623(Kmt5al2) 100909949(Kmt5al1) 288346(Kmt5al3) 307305(Prdm6) 689820(Kmt5a)

MCOC:

116068429(Kmt5a) 116087169(Prdm6)

ANU:	117698248(Kmt5a) 117719895(Prdm6)

MUN:	110552670(Kmt5a) 110559610(Prdm6)

CGE:	100773424(Prdm6) 100774411(Kmt5a)

MAUA:

101824166 101824988(Kmt5a) 101825910(Prdm6)

PROB:

127234198(Prdm6) 127237018(Kmt5a)

PLEU:

114686055 114694780(Prdm6) 114704516(Kmt5a)

MORG:

121437304 121441958 121446283(Kmt5a) 121453606

MFOT:

126504306 126506031

AAMP:

119815859(Prdm6) 119825159(Kmt5a)

NGI:	103738642(Prdm6) 103739033(Kmt5a)

HGL:	101720211(Prdm6) 101726359(Kmt5a)

CPOC:

100734404(Kmt5a)

CCAN:

109683525(Kmt5a) 109694403(Prdm6)

DORD:

105985212(Prdm6) 105990613(Setd8)

DSP:	122098573(Kmt5a) 122103832(Prdm6)

PLOP:

125349195(Kmt5a) 125351358(Prdm6)

NCAR:

124987672 124990908

MMMA:

107155481(Prdm6) 107156385(Kmt5a)

OCU:	100347868 100354345 100354805

OPI:	101516912(PRDM6) 101521103(KMT5A)

TUP:	102471250(KMT5A) 102489496(PRDM6)

GVR:	103585529(PRDM6) 103606858(SETD8)

CFA:	100687856(PRDM6) 610615(KMT5A)

CLUD:

112649926(PRDM6) 112676464

VVP:	112910203(PRDM6)

VLG:	121494210(PRDM6)

NPO:	129494975(PRDM6) 129507931(KMT5A)

AML:	100481447(PRDM6) 100482312(KMT5A)

UMR:	103661256(KMT5A) 103670579(PRDM6)

UAH:	113261649(PRDM6) 113266900(KMT5A)

UAR:	123779868(KMT5A) 123790588(PRDM6)

ELK:	111148449 111156510

LLV:	125082151 125101087

MPUF:

101672174(PRDM6) 101688179(SETD8)

MNP:	132023093(KMT5A) 132028028(PRDM6)

MLK:	131811166(KMT5A) 131832558(PRDM6)

NVS:	122903070(KMT5A) 122916431(PRDM6)

ORO:	101370999(PRDM6) 101380066(SETD8)

EJU:	114200359(KMT5A) 114209391(PRDM6)

ZCA:	113912844(KMT5A) 113929417(PRDM6)

MLX:	118016573(PRDM6) 118018398(KMT5A)

NSU:	110588347(KMT5A) 110591103(PRDM6)

LWW:	102739906(KMT5A)

FCA:	101084511(PRDM6) 101086008(KMT5A)

PYU:	121010394(KMT5A) 121010609(PRDM6)

PCOO:

112860693(PRDM6) 112870284(KMT5A)

PBG:	122470153(KMT5A) 122486759(PRDM6)

PVIV:

125149201(KMT5A) 125174873(PRDM6)

LRUF:

124518212 124522439

PTG:	102956571(PRDM6) 102962714(KMT5A)

PPAD:

109277736(KMT5A) 109278870(PRDM6)

PUC:	125914249 125935443

AJU:	106967577 106975271

HHV:	120236767(KMT5A) 120246097(PRDM6)

BTA:	519857(PRDM6) 532622(KMT5A)

BOM:	102264795(KMT5A) 102279737(PRDM6)

BIU:	109560980 109561855 109571313(KMT5A)

BBUB:

102392447(KMT5A) 102401941(PRDM6)

BBIS:

104989668(SETD8) 104993167(PRDM6)

CHX:	102176319(PRDM6) 102183718(KMT5A)

OAS:	101103235(PRDM6) 101122308(KMT5A)

BTAX:

128051594(PRDM6) 128062161(KMT5A)

ODA:	120864690(PRDM6) 120871058(KMT5A)

CCAD:

122424360(KMT5A) 122440092(PRDM6)

MBEZ:

129542239(KMT5A) 129559287(PRDM6)

SSC:	100524509(PRDM6) 100626555(KMT5A)

CFR:	102513845(PRDM6) 102521782(KMT5A)

CBAI:

105080660(SETD8) 105082233(PRDM6)

CDK:	105102547(KMT5A) 105105065(PRDM6)

VPC:	102527939(KMT5A) 116278202(PRDM6)

BACU:

103012927(KMT5A) 103016372(PRDM6)

BMUS:

118879863(KMT5A) 118892895(PRDM6)

LVE:	103079356(SETD8) 103088820(PRDM6)

OOR:	101270549(KMT5A) 101289146(PRDM6)

DLE:	111182365(PRDM6) 111186967(KMT5A)

PCAD:

102973557(PRDM6) 102996167(KMT5A)

PSIU:

116739152(KMT5A) 116751578(PRDM6)

NASI:

112407769(PRDM6) 112408791(KMT5A)

ECB:	100060853(KMT5A) 100073092(PRDM6)

EPZ:	103549882(KMT5A) 103557946(PRDM6)

EAI:	106842331(KMT5A) 106842785(PRDM6)

MYB:	102240957 102242179 102255214(PRDM6)

MYD:	102763890(PRDM6) 102770785(KMT5A)

MMYO:

118656525 118657022 118678140(KMT5A)

MLF:	102429936(KMT5A)

PKL:	118703399(PRDM6) 118725421(KMT5A)

EFUS:

103286199(PRDM6) 103287217(KMT5A)

MNA:	107529655(KMT5A) 107540856(PRDM6)

DRO:	112310724(KMT5A) 112314700(PRDM6)

SHON:

118974854 118975099(PRDM6) 118991026(KMT5A)

AJM:	119060733(KMT5A) 119063966(PRDM6)

PDIC:

114503519(PRDM6) 114509389(KMT5A)

PHAS:

123818107(PRDM6) 123821187(KMT5A)

MMF:	118639841(KMT5A) 118642786(PRDM6)

PPAM:

129083481(PRDM6) 129087254(KMT5A)

HAI:	109379016(PRDM6) 109386114(KMT5A)

RFQ:	117017602(KMT5A) 117024498(PRDM6)

PALE:

102889990(PRDM6) 102897510(KMT5A)

PGIG:

120590885(PRDM6) 120616022(KMT5A)

PVP:	105289367(KMT5A) 105290874(PRDM6)

RAY:	107511140(PRDM6) 107515249(KMT5A)

MJV:	108400443(PRDM6) 108408425(KMT5A)

TOD:	119243542(PRDM6) 119245049(KMT5A)

SARA:

101540129(SETD8) 101557162(PRDM6)

LAV:	100657495(PRDM6) 100673523(KMT5A)

TMU:	101353514 101358425

ETF:	101641327(KMT5A) 101644936(PRDM6)

DNM:	101414380(KMT5A) 101439546(PRDM6)

MDO:	100014170(PRDM6) 100023739(KMT5A)

GAS:	123231332(PRDM6) 123244631(KMT5A)

SHR:	100919577(PRDM6) 100933547(KMT5A)

AFZ:	127542111 127542390 127545404 127562337

PCW:	110196792(KMT5A) 110223799(PRDM6)

OAA:	100075898(KMT5A) 114808134(PRDM6)

GGA:	416825(KMT5A) 426800(PRDM6)

PCOC:

116228636(KMT5A)

MGP:	100540244(KMT5A)

CJO:	107306730(PRDM6) 107321176(KMT5A)

TPAI:

128084807(KMT5A) 128089575(PRDM6)

LMUT:

125687132(PRDM6) 125701678(KMT5A)

NMEL:

110390181(PRDM6) 110406291(KMT5A)

APLA:

101791393(PRDM6) 101791981(KMT5A)

ACYG:

106031170(KMT5A) 106046221(PRDM6)

CATA:

118257207(KMT5A) 118258319(PRDM6)

AFUL:

116495994(KMT5A) 116501112(PRDM6)

TGU:	100225643(KMT5A) 100229699(PRDM6)

LSR:	110471779(KMT5A) 110479151(PRDM6)

SCAN:

103818327(KMT5A) 103821458 115485138

PMOA:

120509636(KMT5A) 120513557(PRDM6)

OTC:	121331505(PRDM6) 121338931(KMT5A)

PRUF:

121362572(PRDM6) 121365047(KMT5A)

GFR:	102037830(KMT5A) 102042417(PRDM6)

FAB:	101815311(PRDM6) 101821143(KMT5A)

OMA:	130259825(KMT5A) 130265532(PRDM6)

PHI:	102107973(PRDM6) 102109183(SETD8)

PMAJ:

107211636(KMT5A) 107216286(PRDM6)

CCAE:

111936365(KMT5A) 111941215(PRDM6)

CCW:	104688723(KMT5A) 104690502(PRDM6)

CBRC:

103611636(PRDM6) 103616016(KMT5A)

ETL:	114054956(KMT5A) 114055348(PRDM6)

ZAB:	102060759(KMT5A) 102075464(PRDM6)

ACHL:

103797331(PRDM6) 103806489(SETD8)

SVG:	106852006(PRDM6) 106852390(KMT5A)

MMEA:

130574514(PRDM6) 130581001(KMT5A)

HRT:	120760454(KMT5A) 120765604(PRDM6)

FPG:	101914736(KMT5A) 101915352(PRDM6)

FCH:	102050773(PRDM6) 102053153(KMT5A)

CLV:	102089973(KMT5A) 102097159(PRDM6)

EGZ:	104124245(PRDM6) 104130151(SETD8)

NNI:	104012509(PRDM6) 104020902(SETD8)

PCRI:

104023788(SETD8) 104038182

PLET:

104620595(SETD8) 104624542

EHS:	104502556(SETD8) 104513170

PCAO:

104039362(SETD8) 104048902(PRDM6)

ACUN:

113485973(KMT5A) 113489673(PRDM6)

TALA:

104355475(KMT5A) 104362362(PRDM6)

PADL:

103914479(PRDM6) 103914547(SETD8)

AFOR:

103902872(KMT5A) 103903028(PRDM6)

ACHC:

115337406(PRDM6) 115345824(KMT5A)

HALD:

104310615(SETD8) 104318949

HLE:	104828186(PRDM6) 104840920(SETD8)

AGEN:

126035838 126040879

GCL:	127023006 127027726

CCRI:

104160072(PRDM6) 104165021(SETD8)

CSTI:

104549246(SETD8) 104552905(PRDM6)

CMAC:

104473009(SETD8) 104485198

MUI:	104545868(SETD8) 104548511

BREG:

104635738(SETD8) 104638597

FGA:	104069168(SETD8) 104078388(PRDM6)

GSTE:

104250299(SETD8) 104256291(PRDM6)

LDI:	104339768(SETD8) 104348450(PRDM6)

MNB:	103776190 103776967(SETD8)

OHA:	104327609(SETD8) 104327991(PRDM6)

NNT:	104399055(SETD8) 104408128(PRDM6)

SHAB:

115614939(KMT5A) 115619843(PRDM6)

DPUB:

104300379(PRDM6) 104308378(SETD8)

PGUU:

104457692(SETD8) 104465797

ACAR:

104517510(KMT5A) 104525072(PRDM6)

CPEA:

104388755(SETD8) 104391240(PRDM6)

AVIT:

104273219(SETD8) 104275291(PRDM6)

CVF:	104282255(SETD8) 104294239(PRDM6)

RTD:	128902631(PRDM6) 128916957(KMT5A)

CUCA:

104061037(PRDM6) 104068460(SETD8)

TEO:	104369654(SETD8) 104379022(PRDM6)

BRHI:

104492388 104492471(SETD8)

AAM:	106484130 106497676(KMT5A)

AROW:

112962511(KMT5A) 112965157(PRDM6)

NPD:	112945813(KMT5A) 112953531(PRDM6)

TGT:	104574851(SETD8) 104580314(PRDM6)

DNE:	112991842(KMT5A) 112992354(PRDM6)

SCAM:

104138814(SETD8) 104150296(PRDM6)

ASN:	102380913(PRDM6) 102382842(KMT5A)

AMJ:	102569777(PRDM6) 102571182(KMT5A)

CPOO:

109312708(KMT5A) 109323639(PRDM6)

GGN:	109290516(KMT5A) 109297186(PRDM6)

PSS:	102458837(PRDM6) 102463287(KMT5A)

CMY:	102929316(KMT5A) 102942167(PRDM6)

CCAY:

125623204(KMT5A) 125636408(PRDM6)

DCC:	119843904(KMT5A) 119856237(PRDM6)

CPIC:

101932163(KMT5A) 101947533(PRDM6)

TST:	117879252(PRDM6) 117888053(KMT5A)

CABI:

116831030(PRDM6) 116836714(KMT5A)

MRV:	120386460(KMT5A) 120407456(PRDM6)

ACS:	100552008(prdm6) 100559474(kmt5a)

ASAO:

132767240(PRDM6) 132781355(KMT5A)

PVT:	110077521(PRDM6) 110083872(KMT5A)

SUND:

121916628(KMT5A) 121923239(PRDM6)

PBI:	103053204(KMT5A) 103057070(PRDM6)

PMUR:

107285441(KMT5A) 107292729(PRDM6)

CTIG:

120301984(PRDM6) 120316702(KMT5A)

TSR:	106540545(SETD8) 106540743(PRDM6)

PGUT:

117661309(PRDM6) 117672147(KMT5A)

APRI:

131185573(KMT5A) 131193382(PRDM6)

PTEX:

113445479(PRDM6) 113448664(KMT5A)

NSS:	113414534(PRDM6) 113425036(KMT5A)

VKO:	123028707(KMT5A) 123031474(PRDM6)

PMUA:

114586282(KMT5A) 114606447(PRDM6)

PRAF:

128403602(KMT5A) 128423233(PRDM6)

ZVI:	118075547(KMT5A) 118076680(PRDM6)

HCG:	128337839(KMT5A) 128346614(PRDM6)

GJA:	107114655(PRDM6) 107117211(KMT5A)

STOW:

125437159(PRDM6) 125442912(KMT5A)

EMC:	129335019(PRDM6) 129341573(KMT5A)

XLA:	100158384(kmt5a.S) 108707198(prdm6.S) 108717331(prdm6.L) 398318(kmt5a.L)

XTR:	100494529(prdm6) 780276(kmt5a)

NPR:	108787307(KMT5A) 108799254(PRDM6)

RTEM:

120932151(PRDM6) 120934096(KMT5A)

BBUF:

120988467(PRDM6) 120988620(KMT5A)

BGAR:

122934655(KMT5A) 122935336(PRDM6)

MUO:	115463228(PRDM6) 115480711(KMT5A)

GSH:	117352297 117352539(PRDM6) 117365706(KMT5A)

DRE:	100004770(kmt5ab) 101886516(prdm6) 751629(kmt5aa)

SRX:	107706747 107713557 107722327 107726219 107728092 107740028

SANH:

107655184 107657332 107693405(kmt5a) 107702926 107703628 107704173 107704572(prdm6)

SGH:	107548535(kmt5a) 107554512 107556037 107573249(prdm6) 107578348 107588935

CCAR:

109059003 109067610 109074173 109074406 109080144 109084763 109088593 109095529(prdm6)

CAUA:

113052697 113052839 113054712 113085032 113094229(kmt5a) 113106897 113110209

CGIB:

127958296 127963374 127966870 127990317 128018085 128020806

PTET:

122333772(kmt5aa) 122346190(kmt5ab) 122350132(prdm6)

LROH:

127164824(kmt5ab) 127169980(prdm6) 127172239(kmt5aa)

OMC:	131540749(kmt5ab) 131545628(prdm6) 131547944(kmt5aa)

PPRM:

120461932(prdm6) 120472105(kmt5ab) 120483070(kmt5aa)

RKG:	130069118(kmt5ab) 130076729(prdm6) 130094948(kmt5aa)

MAMB:

125262448(kmt5aa) 125267634(kmt5ab) 125280692(prdm6)

CIDE:

127513635 127517329 127521439

MASI:

127414562 127423857 127432609 127433711 127436002

TROS:

130546290(kmt5aa) 130566440(kmt5ab) 130567577(prdm6)

TDW:	130411644(kmt5aa) 130420150(kmt5ab) 130440366(prdm6)

MANU:

129414431(prdm6) 129441120(kmt5ab) 129446503(kmt5aa)

IPU:	108256031(kmt5ab) 108265069 108276718(kmt5aa)

IFU:	128599066(kmt5ab) 128607806(prdm6) 128620161(kmt5aa)

PHYP:

113542401 113544710(kmt5a) 113547211(prdm6)

SMEO:

124393992(kmt5aa) 124399512(prdm6)

TFD:	113638387(kmt5aa) 113655973(prdm6)

TVC:	132854032(prdm6) 132863456(kmt5aa)

AMEX:

103024833 103046457 103046528(prdm6) 111197404

CMAO:

118812882(prdm6) 118824954(kmt5aa) 118827214(kmt5ab)

EEE:	113571045(prdm6) 113581614 113584033(kmt5a)

CHAR:

105889376(kmt5aa) 105905089(kmt5ab) 105907553(prdm6)

TRU:	101062904(kmt5a) 101063309(prdm6) 101068946

TFS:	130517062(kmt5aa) 130525629(kmt5ab) 130526149(prdm6)

TNG:	GSTEN00007631G001 GSTEN00025268G001 GSTEN00029438G001 GSTEN00031036G001

LCO:	104920299(kmt5a) 104935163(prdm6) 104940038

NCC:	104947636 104962306(setd8)

TBEN:

117473218(prdm6) 117476384(kmt5aa) 117496893(kmt5ab)

CGOB:

115013499 115014170(prdm6) 115016800(kmt5a)

PGEO:

117453157(prdm6) 117453176(kmt5ab) 117456051(kmt5aa)

GACU:

117555403(prdm6) 117561043(kmt5ab) 117561434(kmt5aa)

EMAC:

134868523(kmt5aa) 134873978(prdm6) 134874034(kmt5ab)

ELY:	117252541(prdm6) 117253040(kmt5ab) 117269340(kmt5aa)

EFO:	125890454(kmt5ab) 125890825(prdm6) 125906085(kmt5aa)

PLEP:

121944730(prdm6) 121944809(kmt5ab) 121959919

SLUC:

116051045(kmt5aa) 116054117(prdm6) 116056808(kmt5ab)

ECRA:

117944403(prdm6) 117944747(kmt5ab) 117959177(kmt5aa)

ESP:	116689426(prdm6) 116690287 116704008

PFLV:

114556014 114556289(prdm6) 114571152(kmt5a)

GAT:	120831092(kmt5ab) 120831743(kmt5aa)

PPUG:

119224952(kmt5ab) 119225651(prdm6) 119226398(kmt5aa)

AFB:	129101029(kmt5ab) 129101216(prdm6) 129102900(kmt5aa)

CLUM:

117735828(prdm6) 117736716(kmt5ab) 117740929(kmt5aa)

PSWI:

130196067(prdm6) 130196295(kmt5ab) 130205142(kmt5aa)

MSAM:

119891381(kmt5ab) 119891864(prdm6) 119914618(kmt5aa) 119917840

SCHU:

122865281(kmt5aa) 122875973(kmt5ab) 122876825(prdm6)

CUD:	121510055(kmt5ab) 121510064(prdm6) 121524944(kmt5aa)

ALAT:

119019228(prdm6) 119019846(kmt5ab) 119029806(kmt5aa)

MZE:	101468308(prdm6) 101470368(kmt5a) 101485410 112433498 112434147 112436186 112436306

ONL:	100702115 100709871(prdm6) 109194214(kmt5a) 109195113 109202029

OAU:	116313178(kmt5aa) 116313574(prdm6) 116332401(kmt5ab) 120440039 120442224

OLA:	101169793(kmt5a) 101172663 105354834(prdm6)

OML:	112137690(prdm6) 112148771(kmt5ab) 112163317(kmt5aa) 118599191

CSAI:

133450524(kmt5ab) 133450828 133450839(prdm6) 133455038(kmt5aa)

XMA:	102219947(kmt5a) 102220630(prdm6) 102233201

XCO:	114149247(kmt5a) 114154537 114154779(prdm6)

XHE:	116725040(kmt5a) 116729855 116729983(prdm6)

PRET:

103461350 103470267 103470825(prdm6) 103473254(kmt5a)

PFOR:

103151021(kmt5a) 103151865 103151868 103151873 103152623(prdm6)

PLAI:

106942166 106942497 106943016 106945940(prdm6) 106954785(kmt5a)

PMEI:

106909822 106918989(prdm6) 106925250(kmt5a) 106928543 106929479

GAF:	122819727(kmt5aa) 122828541(prdm6) 122828794(kmt5ab)

PPRL:

129365904(prdm6) 129372146(kmt5ab) 129374296(kmt5aa)

CVG:	107084661(prdm6) 107086058 107087301

CTUL:

119784767(kmt5aa) 119784854(prdm6) 119790158(kmt5ab)

GMU:	124872904(kmt5aa) 124877283(prdm6) 124878265(kmt5ab)

NFU:	107375146 107386117(prdm6) 107394219(kmt5a)

KMR:	108234482(kmt5ab) 108245860(prdm6) 108248169(kmt5aa)

ALIM:

106511939 106523808(setd8) 106527566 106533133

NWH:	119413069(kmt5ab) 119425123(kmt5aa)

AOCE:

111565810 111566914(prdm6) 111576642

MCEP:

124996558(kmt5aa) 125012176(kmt5ab) 125012780(prdm6)

CSEM:

103389958 103397505 103397995(prdm6)

POV:	109626470(kmt5a) 109638204

SSEN:

122758422(kmt5aa) 122769022(kmt5ab) 122769149(prdm6)

HHIP:

117767484(kmt5ab) 117768446(prdm6) 117771531(kmt5aa)

HSP:	118098042(kmt5aa) 118114691(prdm6) 118115071(kmt5ab)

SMAU:

118310057(kmt5aa) 118313817(prdm6) 118314035

LCF:	108874937 108878140(kmt5ab) 108897302(kmt5aa)

SDU:	111217857(kmt5a) 111230938 111239241(prdm6)

SLAL:

111649965 111658242 111667134(prdm6)

XGL:	120805543(kmt5ab) 120805697(prdm6) 120806784(kmt5aa)

HCQ:	109513448(prdm6) 109525154 109529122

SSCV:

125979925 125994035 125994152

SBIA:

133490551(kmt5aa) 133498922(prdm6) 133499651(kmt5ab)

PEE:	133400124(kmt5ab) 133400162(prdm6) 133413732(kmt5aa)

PTAO:

133474871(kmt5ab) 133475748(prdm6) 133489815(kmt5aa)

BPEC:

110168947 110171341 110172486(kmt5a)

MALB:

109953053 109957446(prdm6) 109961594(kmt5a)

BSPL:

114861706(prdm6) 114862890(kmt5ab) 114866997(kmt5aa)

SJO:	128365016(kmt5ab) 128380747(kmt5aa)

SASA:

106562505 106568287 106568308 106585273(kmt5a) 106587041(prdm6)

STRU:

115149301(kmt5a) 115159250 115164478 115167640(prdm6)

OTW:	112219631(kmt5aa) 112233539(kmt5ab) 112248945(prdm6) 112257473

OMY:	110523849 110525699(kmt5ab) 110526138(prdm6) 110537078

OGO:	123999640(kmt5aa) 124033969(prdm6) 124034294 124048656

ONE:	115105910(kmt5a) 115111631 115112017(prdm6) 115127850

OKI:	109868488 109874149(prdm6) 109880068 109892437

OKE:	118387821 118391486 118393236 118393619(prdm6)

SALP:

111958152 111961353 111973725(prdm6) 111974204 111981803(kmt5a)

SNH:	120023165(kmt5ab) 120026139 120044218 120051923(prdm6)

CCLU:

121530937 121574138 121582766 121584618(prdm6)

ELS:	105014800(kmt5a) 105025387(prdm6) 105026110

SFM:	108934749(kmt5a) 108938054(prdm6)

PKI:	111856522(prdm6) 111860044(kmt5a)

AANG:

118206487(kmt5ab) 118206970(prdm6) 118213194(kmt5aa)

LOC:	102686646(kmt5a) 102697014(prdm6)

PSPA:

121296780 121299694 121302484 121315476

ARUT:

117408833 117426360 117962465 117962511

PSEX:

120532709(prdm6) 120540871(kmt5aa)

LCM:	102355801(KMT5A) 102357740(PRDM6)

CMK:	103182382(prdm6) 103188010

RTP:	109918332(kmt5ab)

CPLA:

122551012 122565544

HOC:	132827003 132827953(prdm6)

LERI:

129695800(prdm6) 129709245

PMRN:

116942008(PRDM6) 116944662(KMT5A)

LRJ:	133340495(KMT5A) 133343740(PRDM6)

BFO:	118409536 118426346

BBEL:

109463004 109476176 109484669

CIN:

100176062

SCLV:

120342049

SPU:	100892850 105440265 105442287 115917928 115918102 115921211 115921240 115923119 115926391 592467

LPIC:

129258272

APLC:

110987820

AJC:

117108879

SKO:	100313707 100367079

DME:	Dmel_CG3307(Set8)

DER:

6552524

DSE:

6606408

DSI:	Dsimw501_GD18956(Dsim_GD18956)

DYA:	Dyak_GE24231

DSR:

110176489

DPO:

4801942

DPE:

6587245

DMN:

108155042

DWI:

6647761

DGR:

6568421

DMO:	Dmoj_GI22805

DAZ:

108621090

DNV:

108659415

DHE:

111601499

DVI:

6631209

CCAT:

101458467

BOD:

106617779

BDR:

105229910

RZE:

108367961

AOQ:

129252920

TDA:

119677458

MDE:	101900242 131803727

LCQ:

111690642

LSQ:

119600570

GFS:

119634779

ECOE:

129954104

AGA:

1274161

ACOZ:

120961174

AARA:

120908677

AMER:

121589543

ASTE:

118517717

AFUN:

125767766

AMOU:

128297853

AALI:

118465873

AAG:

5570016

CQU:	CpipJ_CPIJ000732

CPII:

120419555

CNS:	116344844 116344849

BCOO:

119084217

AME:

412027

ACER:

107997274

ALAB:

122711479

ADR:

102675279

AFLR:

100872063

BIM:

100745456

BBIF:

117216719

BVK:

117232767

BVAN:

117164919

BTER:

100649334

BAFF:

126924694

BPYO:

122570154

BPAS:

132914266

FVI:

122529823

CCAL:

108631655

OBB:

114877636

OLG:

117604946

MGEN:

117221976

NMEA:

116426766

CGIG:

122396133

SOC:

105195427

MPHA:

105838593

AEC:

105146968

ACEP:

105619051

PBAR:

105426851

VEM:

105560777

HST:

105188422

DQU:

106743812

CFO:

105251700

FEX:

115234102

LHU:

105673005

PGC:

109855440

OBO:

105281625

PCF:

106791652

PFUC:

122518984

VPS:

122634476

VCRB:

124429987

VVE:

124954677

NVI:	100123008 100123020 100677939

CSOL:

105359046 105368743

TPRE:

106658250 106658254 111693283

LHT:

122511522

LBD:

127277317

MDL:

103578031

FAS:

105263204

DAM:

107039969

AGIF:

122851993

VCAN:

122419548

CCIN:

107273195

DSM:

124407198

NPT:

124214562

NFB:

124177945

NLO:

107217471

NVG:

124300327

AROA:

105685147

TCA:

657891

DPA:	109543766 109543771

SOY:

115881507

AGRG:

126733460 126749230

ATD:

109602979

CSET:

123319926

AGB:	108909439 108909442

LDC:

111509070

NVL:

108557301

APLN:

108737955

PPYR:

116162082

OTU:

111423470

BMOR:

101738260

MSEX:

115441344

DPL:	KGM_206896

BANY:

112049996

MJU:

123871380

NIQ:

126775229

VCD:

124532782

MCIX:

123663426

PMAC:

106709118

PPOT:

106108377

PXU:

106117926

PRAP:

111004357

PBX:

123709244

PNAP:

125054222

ZCE:

119833070

CCRC:

123700481

LSIN:

126974211

HAW:

110370812

HZE:

124639441

TNL:	113502956 113509008

SLIU:

111360462 111360948

OFU:

114364202

PXY:	105384001 105394816

PGW:

126376040

CCRN:

123299042

API:

100161505

DNX:

107170040

AGS:

114119070

RMD:

113548056

ACOO:

126846096

DVT:

126909599

BTAB:

109032364

DCI:

103508290

CLEC:

106663755

HHAL:

106681150

NLU:	111047050 120352923

HVI:

124369030

MQU:

128997949

PHU:	Phum_PHUM315980

FOC:

113207206

TPAL:

117642704 117651861

ZNE:

110830787

CSEC:

111862820

SGRE:

126285361

BROR:

134532903

IEL:

124155832

FCD:

110853144

DPX:	DAPPUDRAFT_311914

DMK:

116931250

DPZ:

124349030

PVM:

113807185

PJA:

122266915

PCHN:

125035469

PMOO:

119583751

HAME:

121868774

PCLA:

123757935

CQD:

128703843

PTRU:

123512449

ESN:

127008651

HAZT:

108667100

EAF:	111697097 111709992

LSM:

121127499

TCF:	131884070 131886047

PPOI:

119099287 119099433

DSV:

119445842

RSAN:

119390239

RMP:

119172941

VDE:

111255286

VJA:

111260884

TUT:	107366892 107367013

DPTE:

113793328

DFR:

124495473

CSCU:

111636826

PTEP:

107444515

ABRU:

129971399

UDV:	129218562 129226092

SDM:

118195453

LPOL:

106472304

PMEO:

129589222

CEL:	CELE_T26A5.7(set-1)

CBR:	CBG_16281 CBG_16282 CBG_19678(Cbr-set-1)

CRQ:	GCK72_010704 GCK72_023057

NAI:	NECAME_10199

BMY:	BM_BM12185(Bma-set-1)

LOA:	LOAG_02341

TSP:	Tsp_09846 Tsp_09848

LGI:	LOTGIDRAFT_117025

PVUL:

126823902

PCAN:

112562936

BGT:	106067552 106070335

GAE:

121368110

HRF:

124133359

HRJ:	124272407 124276593

CRG:	105318653 117684757

CVN:

111134306

CANU:

128186593

OED:

125650397

MYI:	110442348 110445834

PMAX:

117333146

MCAF:

127712630

MMER:

123533535 123547644

RPHI:

132754519

DPOL:

127870116

OBI:

106878187

OSN:	115216802 115228427

LAK:

106173811

SMM:	Smp_055310

SHX:	MS3_00005891(KMT5A)

OVI:	T265_05161

EGL:

EGR_02931

NVE:	116601963 116619195 116619196 116619198 5509219 5510380 5510391 5514175 5518226 5518227 5520359

EPA:	110232839 110242476 110252276 110252283 110253323 110253439 110253440 110253496 110253497 110253500

ATEN:

116288855 116290567 116290576 116290935 116303623 116303624 116303633 116305629

ADF:	107333633 107333634 107333696 107333697 107333699 107333700 107333701 107343202 107347668

AMIL:

114953657 114956003 114961844 114961845 114961846 114961847 114961848 114961850 114961851 114972890

PDAM:

113670441 113672624 113672625 113672651 113672652 113672653 113672654 113672655 113679436 113684845

SPIS:

111322434 111322526 111322790 111322987 111333025 111335406 111335791 111336163 111336247 111339595

DGT:	114522454 114522456 114522520 114522531 114522584 114522647 114522697 114537567 114538303

XEN:	124434221 124450553 124454775 124454793 124454879

HMG:	100201879 100204152 100208645

HSY:

130655788

TAD:	TRIADDRAFT_59058

AQU:	100636664 100639445

SRE:	PTSG_09393

DFA:

DFA_00963

PFA:	PF3D7_0403900

PFD:	PFDG_02606

PFH:	PFHG_00728

PREI:

PRSY57_0401500

PGAB:

PGSY75_0403900

PYO:	PY17X_1003000

PCB:	PCHAS_1002500

PBE:	PBANKA_1001600

PVV:	PVVCY_0800190

PKN:	PKNH_0301900

PVX:	PVX_001050

PCY:	PCYB_031160

PREL:

PRELSG_0301100(SET8)

TAN:

TA21435

TPV:

TP01_0281

TOT:	TOT_010000260

BEQ:	BEWA_031890

BBO:	BBOV_IV004680

BMIC:

BMR1_02g00765

CPV:

cgd4_370

CHO:	Chro.40051

» show all

Reference

1 [PMID:12121615]

Authors

Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y

Title

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.

Journal

Curr Biol 12:1086-99 (2002)
DOI:10.1016/s0960-9822(02)00924-7

Sequence

[hsa:387893]

Reference

2 [PMID:12086618]

Authors

Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D

Title

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.

Journal

Mol Cell 9:1201-13 (2002)
DOI:10.1016/s1097-2765(02)00548-8

Sequence

[hsa:387893]

Reference

3 [PMID:18166648]

Authors

Jorgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sorensen CS

Title

The histone methyltransferase SET8 is required for S-phase progression.

Journal

J Cell Biol 179:1337-45 (2007)
DOI:10.1083/jcb.200706150

Sequence

[hsa:387893]

Reference

4 [PMID:19223465]

Authors

Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM, Torres-Padilla ME, Heard E, Reinberg D

Title

Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.

Journal

Mol Cell Biol 29:2278-95 (2009)
DOI:10.1128/MCB.01768-08

Sequence

[mmu:67956]

Reference

5 [PMID:23345616]

Authors

Jorgensen S, Schotta G, Sorensen CS

Title

Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.

Journal

Nucleic Acids Res 41:2797-806 (2013)
DOI:10.1093/nar/gkt012

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.361

IUBMB Enzyme Nomenclature:

2.1.1.361

ExPASy - ENZYME nomenclature database:

2.1.1.361

BRENDA, the Enzyme Database:

2.1.1.361

DBGET integrated database retrieval system