KEGG ENZYME: 2.1.1.362

ENZYME: 2.1.1.362

Entry

EC 2.1.1.362                Enzyme

Name

[histone H4]-N-methyl-L-lysine20 N-methyltransferase;
KMT5B (gene name);
KMT5C (gene name);
SUV420H1 (gene name);
SUV420H2 (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[histone H4]-N6-methyl-L-lysine20 N6-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20

Reaction(KEGG)

(other) R04866

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-N6-methyl-L-lysine20

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6,N6-dimethyl-L-lysine20

Comment

This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.

History

EC 2.1.1.362 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.362

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K11429

[histone H4]-N-methyl-L-lysine20 N-methyltransferase

Genes

HSA:	51111(KMT5B) 84787(KMT5C)

PTR:	451378(KMT5B) 735868(KMT5C)

PPS:	100984020(KMT5C) 100995372(KMT5B)

GGO:	101139439(KMT5C) 101151252(KMT5B)

PON:	100450271(KMT5B) 100450936(KMT5C)

NLE:	100583977(KMT5B) 100599527(KMT5C)

HMH:	116469101(KMT5B) 116479217(KMT5C)

MCC:	699963(KMT5C) 710481(KMT5B)

MCF:	102117388(KMT5B) 102129054(KMT5C)

MTHB:

126935948 126943220

MNI:	105469702(KMT5B) 105488178(KMT5C)

CSAB:

103215291(KMT5B) 103235303(KMT5C)

CATY:

105577329(SUV420H1) 105582752(SUV420H2)

PANU:

101000900(KMT5B) 101018573(KMT5C) 116268663

TGE:	112606406(KMT5B) 112612678(KMT5C)

MLEU:

105544489(SUV420H1) 105551629(SUV420H2)

RRO:	104664716(KMT5B) 104674764(KMT5C)

RBB:	108518702(KMT5B) 108542541(KMT5C)

TFN:	117081487(KMT5B) 117091737(KMT5C)

PTEH:

111521169(KMT5C) 111522408(KMT5B)

CANG:

105504865(SUV420H2) 105512070

CJC:	100393036(KMT5C) 100400804(KMT5B)

SBQ:	101047990(SUV420H2) 101053072(SUV420H1)

CIMI:

108310169(KMT5B) 108316620(KMT5C)

CSYR:

103271344(KMT5C)

MMUR:

105863301 105867495(KMT5B) 105877204(KMT5C)

LCAT:

123624698(KMT5C) 123642818(KMT5B)

PCOQ:

105809303(SUV420H2) 105827445(SUV420H1)

OGA:	100966648(KMT5C)

MMU:	225888(Kmt5b) 232811(Kmt5c)

MCAL:

110285500(Kmt5b) 110298763(Kmt5c)

MPAH:

110334213(Kmt5b) 110336454(Kmt5c)

RNO:	308345(Kmt5c) 361688(Kmt5b)

MCOC:

116101555(Kmt5c) 116103298(Kmt5b)

ANU:	117701105(Kmt5c) 117707287(Kmt5b)

MUN:	110547082(Kmt5b) 110561067(Kmt5c)

CGE:	100761878(Kmt5b) 100772952(Kmt5c)

MAUA:

101828847(Kmt5c) 101833552(Kmt5b)

PROB:

127228611(Kmt5b) 127238387(Kmt5c)

PLEU:

114687711(Kmt5c) 114694607(Kmt5b)

MORG:

121449456(Kmt5c) 121453889(Kmt5b)

MFOT:

126493683 126498648

AAMP:

119811801(Kmt5b) 119821526(Kmt5c)

NGI:	103744517(Kmt5b) 103744814(Kmt5c)

HGL:	101707567(Kmt5c) 101719039(Kmt5b)

CPOC:

100713625(Kmt5c) 100727663(Kmt5b)

CCAN:

109692079(Kmt5b) 109696272(Kmt5c)

DORD:

105989210(Suv420h1) 105999513(Suv420h2)

DSP:	122104871(Kmt5b) 122110645(Kmt5c)

PLOP:

125338623(Kmt5c) 125361309(Kmt5b)

NCAR:

124958337 124966912

MMMA:

107157022(Kmt5b) 107158903(Kmt5c)

OCU:

100340037

OPI:	101530071(KMT5B) 101531050(KMT5C)

TUP:	102474475 102497986(KMT5B) 102499452(KMT5C)

GVR:	103588003(SUV420H1) 103606740(SUV420H2)

CFA:	483690(KMT5B) 484295(KMT5C)

CLUD:

112644992(KMT5C) 112659549(KMT5B)

VVP:	112909339(KMT5C) 112924166(KMT5B)

VLG:	121485831(KMT5C) 121501552(KMT5B)

NPO:	129499487(KMT5B) 129500725(KMT5C)

AML:	100468595(KMT5B) 100478438(KMT5C)

UMR:	103679527(KMT5B) 103680304(KMT5C)

UAH:	113244004(KMT5B) 113247443(KMT5C)

UAR:	123778528(KMT5B) 123786942(KMT5C)

ELK:	111139579 111149436

LLV:	125078124 125089130

MPUF:

101671221(SUV420H2) 101680981(SUV420H1)

MNP:	132005199(KMT5C) 132017661(KMT5B)

MLK:	131816762(KMT5B) 131818377(KMT5C)

NVS:	122912178(KMT5C) 122913278(KMT5B)

ORO:	101374708(SUV420H2) 101375610(SUV420H1)

EJU:	114202071(KMT5C) 114220184(KMT5B)

ZCA:	113913906(KMT5B) 113935831(KMT5C)

MLX:	117997814(KMT5C) 118016151(KMT5B)

NSU:	110573610(KMT5C) 110576382(KMT5B)

LWW:	102741747(KMT5C)

FCA:	101091322(KMT5C) 101094702(KMT5B)

PYU:	121023446(KMT5C) 121023792(KMT5B)

PCOO:

112852038(KMT5B)

PBG:	122484079(KMT5B) 122493730(KMT5C)

PVIV:

125153233(KMT5C) 125176158(KMT5B)

LRUF:

124506313 124527747

PTG:	102953097(KMT5C) 102963329(KMT5B)

PPAD:

109246874(KMT5B) 109259888(KMT5C)

PUC:	125915518 125930229

AJU:	106971172 106980935

HHV:	120233920(KMT5B) 120239642(KMT5C)

BTA:	519777(KMT5C) 767828(KMT5B)

BOM:	102268312(KMT5B) 102288327(KMT5C)

BIU:	109572897(KMT5C)

BBUB:

102390793(KMT5C) 102405866(KMT5B)

BBIS:

104986946(SUV420H1) 104997708(SUV420H2)

CHX:	102185214(KMT5C) 102185720(KMT5B)

OAS:	101111001 101121289(KMT5C) 101121812(KMT5B)

BTAX:

128063558(KMT5C) 128068679(KMT5B)

ODA:	120871894(KMT5C) 120874128(KMT5B)

CCAD:

122421123(KMT5C) 122430562(KMT5B)

MBEZ:

129545985(KMT5C) 129548677(KMT5B)

SSC:	100521358(KMT5B) 110261054(KMT5C)

CFR:	102520054(KMT5B) 116666001(KMT5C)

CBAI:

105070355(SUV420H1) 105074363(SUV420H2)

CDK:	105098743(KMT5C) 105104405(KMT5B)

VPC:	102526722(KMT5B) 102544997(KMT5C)

BACU:

102997321(KMT5C) 103007228(KMT5B)

BMUS:

118885682(KMT5C) 118899257(KMT5B)

LVE:	103090973(SUV420H2) 103091082(SUV420H1)

OOR:	101269348(KMT5C) 101270232(KMT5B)

DLE:	111181001(KMT5C) 111183648(KMT5B)

PCAD:

102982740(KMT5C) 102994432(KMT5B)

PSIU:

116743805(KMT5C) 116757549(KMT5B)

NASI:

112402088(KMT5B) 112406445(KMT5C)

ECB:	100053438(KMT5B) 100055743(KMT5C)

EPZ:	103551272(KMT5B) 103562880(KMT5C)

EAI:	106840934(KMT5C) 106844276(KMT5B)

MYB:	102257692(KMT5B)

MYD:	102762755(KMT5B)

MMYO:

118655158(KMT5C) 118665198(KMT5B)

MLF:	102423838(KMT5B)

PKL:	118706936(KMT5B) 118718049(KMT5C)

EFUS:

103290910(KMT5B) 103304206(KMT5C)

MNA:	107537430(KMT5B) 107541336(KMT5C)

DRO:	112313746(KMT5C) 112317051(KMT5B)

SHON:

118981365(KMT5C) 118998385(KMT5B)

AJM:	119041826(KMT5B) 119059966(KMT5C)

PDIC:

114499232(KMT5B) 114511636(KMT5C)

PHAS:

123813333(KMT5C) 123829288(KMT5B)

MMF:	118628825(KMT5B) 118639430(KMT5C)

PPAM:

129068531(KMT5B) 129082513(KMT5C)

HAI:	109373782(KMT5C) 109389302(KMT5B)

RFQ:	117030117(KMT5B) 117035542(KMT5C)

PALE:

102887326(KMT5B) 102887846(KMT5C)

PGIG:

120584736(KMT5B) 120598318(KMT5C)

PVP:	105304911(KMT5C) 105306566(KMT5B)

RAY:	107503474(KMT5B) 107515406(KMT5C)

MJV:	108388709(KMT5C) 108405830(KMT5B)

TOD:	119249888(KMT5B) 119250478(KMT5C)

SARA:

101553901(SUV420H1) 101559080(SUV420H2)

SETR:

126019048(KMT5B) 126028006(KMT5C)

LAV:	100671600(KMT5B) 100671832(KMT5C)

TMU:	101357481 101362054

ETF:	101651126(KMT5C) 101656417(KMT5B)

DNM:	101441925(KMT5C)

MDO:	100010281(KMT5B)

GAS:	123252988(KMT5B) 123254396(KMT5C)

SHR:	100917457(KMT5B)

AFZ:	127540200 127556724

PCW:	110195350(KMT5B) 110219937(KMT5C)

OAA:	100088070(KMT5B) 114814778(KMT5C)

GGA:	101748081(KMT5C) 425119(KMT5B)

PCOC:

116238984(KMT5B) 116239624(KMT5C)

MGP:	100547012(KMT5B) 116217397

CJO:	107307235(KMT5C) 107314523(KMT5B)

TPAI:

128086357(KMT5B)

LMUT:

125695486(KMT5B)

NMEL:

110391343(KMT5C) 110401096(KMT5B)

APLA:

101803754(KMT5B)

ACYG:

106038840(KMT5B)

CATA:

118244533(KMT5B)

AFUL:

116489780(KMT5B)

TGU:	100222904(KMT5B)

LSR:	110484490(KMT5B)

SCAN:

103824088(KMT5B)

PMOA:

120511379(KMT5B)

OTC:	121344840(KMT5B)

PRUF:

121360949(KMT5B)

GFR:	102041210(KMT5B)

FAB:	101805731(KMT5B)

OMA:	130253841(KMT5B)

PHI:	102102011(SUV420H1) 102106962(SUV420H2)

PMAJ:

107205911(KMT5B)

CCAE:

111930710(KMT5B)

CCW:	104692390(KMT5B)

CBRC:

103620700(KMT5B)

ETL:	114064814(KMT5B)

ZAB:	102071604(KMT5B)

ACHL:

103805574(SUV420H1)

SVG:	106851550(KMT5B) 106864459

MMEA:

130576653(KMT5B)

HRT:	120754187(KMT5B)

FPG:	101921673(KMT5B)

FCH:	102046441(KMT5B)

CLV:	102091143(KMT5B)

EGZ:	104132445(SUV420H1)

NNI:	104017300(SUV420H1)

PCRI:

104026157

PLET:

104618335(SUV420H1)

EHS:	104514178(SUV420H1)

PCAO:

104043641(SUV420H1)

ACUN:

113481137(KMT5B)

TALA:

104357837(KMT5B)

PADL:

103919876(SUV420H1)

AFOR:

103896207(KMT5B)

ACHC:

115351814(KMT5B)

HLE:	104828682(SUV420H1)

AGEN:

126047232

GCL:

127017132

CCRI:

104165104(SUV420H1)

CSTI:

104550151

CMAC:

104475633(SUV420H1)

MUI:	104537217(SUV420H1)

BREG:

104631869(SUV420H1)

FGA:

104069536

GSTE:

104263977(SUV420H1)

LDI:	104340891(SUV420H1)

OHA:	104335343(SUV420H1)

NNT:	104403667(SUV420H1)

SHAB:

115606246(KMT5B)

DPUB:

104305321(SUV420H1)

PGUU:

104462803(SUV420H1)

ACAR:

104522194(KMT5B)

CPEA:

104387645(SUV420H1)

AVIT:

104272970

CVF:	104290287(SUV420H1)

RTD:	128908140(KMT5B)

CUCA:

104068926(SUV420H1)

TEO:	104371630(SUV420H1)

BRHI:

104493421(SUV420H1)

AAM:	106494851 106494860(KMT5B)

AROW:

112962693(KMT5B)

NPD:	112948832(KMT5B)

TGT:	104580551(SUV420H1)

DNE:	112987944(KMT5B)

SCAM:

104143710(SUV420H1)

ASN:	102378990(KMT5C) 102379587(KMT5B)

AMJ:	102559156(KMT5C) 102568601(KMT5B)

CPOO:

109318193(KMT5B)

GGN:	109299233(KMT5B)

PSS:	102456135(KMT5B)

CMY:	102946000(KMT5B) 119564929(KMT5C)

CCAY:

125627871(KMT5C) 125637692(KMT5B)

DCC:	119847136(KMT5C) 119857546(KMT5B)

CPIC:

101932218 101950551(KMT5B)

TST:	117877341(KMT5B) 117888425

CABI:

116837275(KMT5B) 116840038(KMT5C)

MRV:	120404891(KMT5B)

ACS:	100553817(kmt5b) 100562840(suv420h2)

ASAO:

132771544(KMT5B) 132777909(KMT5C)

PVT:	110074171(KMT5B) 110078503(KMT5C)

SUND:

121928073(KMT5B) 121934852(KMT5C)

PBI:	103053694(KMT5B) 103066601(KMT5C)

PMUR:

107282452(KMT5C) 107295878(KMT5B) 107296922

CTIG:

120302588(KMT5B) 120304505(KMT5C)

TSR:	106547726 106553569(SUV420H1)

PGUT:

117665172(KMT5B) 117669086(KMT5C)

APRI:

131184829(KMT5B) 131197428(KMT5C)

PTEX:

113440324(KMT5B) 113443539(KMT5C)

NSS:	113412502(KMT5B) 113418532(KMT5C)

VKO:	123021166(KMT5B) 123032305(KMT5C)

PMUA:

114599913(KMT5B) 114608036(KMT5C)

PRAF:

128400684(KMT5C) 128417137(KMT5B)

ZVI:	118088653(KMT5B) 118094429(KMT5C)

HCG:	128330397(KMT5C) 128336346(KMT5B)

GJA:	107118429(KMT5C) 107119069(KMT5B)

STOW:

125425986(KMT5B) 125444823(KMT5C)

EMC:	129324362(KMT5B) 129338162(KMT5C)

XLA:	108697809(kmt5c.S) 444204(kmt5b.S) 495826(kmt5b.L) 779432(kmt5c.L)

XTR:	100038141(kmt5b) 100145748(kmt5c)

NPR:	108784118(KMT5B) 108795144

RTEM:

120915318 120917547(KMT5B)

BBUF:

120981232(KMT5B) 121001291(KMT5C)

BGAR:

122920197(KMT5B) 122928660(KMT5C)

MUO:	115466545(KMT5C) 115469037(KMT5B)

GSH:	117352111(KMT5B) 117368145(KMT5C)

DRE:	569041(kmt5c) 572849(kmt5b)

SRX:	107726382 107729507 107732880 107738677

SANH:

107658443 107672243 107674147 107694947

SGH:	107563992 107583067 107583742 107596936

CCAR:

109059335 109059339 109060235 109060291

CAUA:

113046445 113047040 113070223 113118399

CGIB:

127934317 127977574

PTET:

122362994(kmt5b)

LROH:

127180974(kmt5b)

OMC:	131524231(kmt5b)

PPRM:

120487671

RKG:	130088183(kmt5b) 130097241(kmt5c)

MAMB:

125254463(kmt5b)

CIDE:

127499887

MASI:

127416989 127456131

TROS:

130562669(kmt5b)

TDW:	130426382(kmt5c) 130435454(kmt5b)

MANU:

129419194(kmt5b) 129436122(kmt5c)

IPU:	108264420(kmt5b) 108271342 108280634(kmt5c)

IFU:	128606742(kmt5b) 128613945

PHYP:

113534430(kmt5b) 113536364

SMEO:

124391472 124395577(kmt5b) 124397332(kmt5c)

TFD:	113652428(kmt5b) 113663272

TVC:	132845935 132851202(kmt5b) 132860921(kmt5c)

AMEX:

103025343 103035158(kmt5b)

CMAO:

118817807(kmt5b) 118818984

EEE:	113573589 113575774

CHAR:

105897685(kmt5c) 105904509(kmt5b) 105910380

TRU:	101069597 101076428(kmt5b)

TFS:	130515281(kmt5c) 130518565(kmt5b)

TNG:	GSTEN00005213G001 GSTEN00027784G001

LCO:	104937792(kmt5b)

NCC:	104958752(suv420h1)

TBEN:

117472251(kmt5b) 117492569(kmt5c)

CGOB:

115012065 115026499

PGEO:

117450888(kmt5c) 117463000(kmt5b)

GACU:

117548447(kmt5c) 117557837(kmt5b)

EMAC:

134863037(kmt5b) 134878158(kmt5c)

ELY:	117254537(kmt5b)

EFO:	125879374(kmt5c) 125880866(kmt5b)

PLEP:

121964343(kmt5b)

SLUC:

116067275(kmt5b)

ECRA:

117936389(kmt5b)

ESP:	116689597(kmt5b) 116702548

PFLV:

114554902(kmt5b)

GAT:	120809098(kmt5b)

PPUG:

119194941(kmt5b)

AFB:	129098921(kmt5c) 129105105(kmt5b)

CLUM:

117734696(kmt5c) 117749488(kmt5b)

PSWI:

130188890(kmt5c) 130192517(kmt5b)

MSAM:

119889981(kmt5b) 119893874(kmt5c) 119899939 119912002 119912004 119912054 119912055

SCHU:

122868886(kmt5c) 122881996(kmt5b)

CUD:	121507226(kmt5b) 121525183

ALAT:

119017849(kmt5b)

MZE:	101471827(kmt5b) 101477849

ONL:	100691614 100700783(kmt5b)

OAU:	116328928(kmt5c) 116334293(kmt5b)

OLA:	101156070(kmt5b) 101165555

OML:	112160800(kmt5b)

CSAI:

133418598(kmt5b) 133421454(kmt5c)

XMA:	102220708(kmt5b) 102236356

XCO:	114143669(kmt5b) 114159982

XHE:	116719207(kmt5b)

PRET:

103460097(kmt5b) 103468964

PFOR:

103153448(kmt5b)

PLAI:

106949316(kmt5b)

PMEI:

106904685(kmt5b)

GAF:	122823807(kmt5b)

PPRL:

129355547 129373685(kmt5c)

CVG:	107085059(kmt5b) 107096940

CTUL:

119773604(kmt5b)

GMU:	124866992(kmt5b)

NFU:	107378497 107381531(kmt5b)

KMR:	108237783(kmt5c) 108250521(kmt5b)

ALIM:

106532050(suv420h1)

NWH:	119424991(kmt5b)

AOCE:

111578621(kmt5b)

MCEP:

124998187(kmt5c) 125005255(kmt5b)

CSEM:

103379016(kmt5b)

POV:	109634192 109645819(kmt5b)

SSEN:

122772416(kmt5b)

HHIP:

117779341(kmt5b)

HSP:	118106138(kmt5b) 118109361 118123194(kmt5c)

SMAU:

118289516(kmt5c)

LCF:

108894245

SDU:	111217719 111224033(kmt5b)

SLAL:

111656626(kmt5b) 111660544

XGL:	120784195(kmt5c) 120803744(kmt5b)

HCQ:	109514373(kmt5b) 109527740

SSCV:

125966765

SBIA:

133498667(kmt5b) 133514330(kmt5c)

PEE:	133395692(kmt5b) 133415033(kmt5c)

PTAO:

133465643(kmt5c) 133474480(kmt5b)

BPEC:

110168042(kmt5b)

MALB:

109951248(kmt5b) 109963137

BSPL:

114852062(kmt5b)

SJO:	128379305(kmt5c) 128384951(kmt5b)

SASA:

106560809 106573759 106587945 106601577 106601580

STRU:

115151974 115166698 115196783 115203585

OTW:	112218551(kmt5b) 112252375 112255835

OMY:	110486659 110495327(kmt5b) 110520608 110526840 110526843 110538619

OGO:	124000754 124015425 124018489 124036872(kmt5b)

ONE:	115109400 115110747 115110921 115115615 115134271

OKI:	109867243 109880608 109880610 109888842 109898722 116374488

OKE:	118372900 118396687 118401244 127929335

SALP:

111952187 111962386 111968141 111982123

SNH:	120034096 120040364 120053924 120066257(kmt5b)

CCLU:

121531884 121560684 121570210 121576631

ELS:	105023468 105029585(kmt5b)

SFM:	108934513(kmt5b) 108941728(kmt5c) 108942441

PKI:	111841219 111859433

AANG:

118215224(kmt5b) 118228085

LOC:	102687526(kmt5b)

PSPA:

121294829 121305894(kmt5c) 121330193

ARUT:

117432399 117435056

PSEX:

120516912(kmt5b) 120542450(kmt5c)

LCM:	102357247(KMT5C) 102357304(KMT5B)

CMK:	103174937(kmt5b) 103189530

RTP:	109912567(kmt5b)

CPLA:

122542218 122557830(kmt5b)

HOC:	132824425(kmt5b) 132831255

LERI:

129705710(kmt5b) 129713956

PMRN:

116939989 116945526

LRJ:	133350242 133351523

BFO:

118413910

BBEL:

109482963

CIN:

100186975

SCLV:

120342400

SPU:

583266

APLC:

110975028

SKO:

100372808

DME:	Dmel_CG13363(Hmt4-20)

DER:

6555511

DSE:

6615887

DSI:	Dsimw501_GD16466(Dsim_GD16466)

DYA:	Dyak_GE16574

DSR:

110178198

DPO:

6901853

DPE:

6600100

DMN:

108164669

DWI:

6644812

DGR:

6569283

DAZ:

108618025

DNV:

108655611

DHE:

111596240

CCAT:

101453125

BOD:

106621763

AOQ:

129237224

TDA:

119669148

MDE:	101897840 131800345

SCAC:

106085721

LCQ:

111679605

LSQ:

119604114

ECOE:

129944459

AGA:

3289600

ACOZ:

120956120

AAG:	110677788 5569935

AALB:

109427501 115256334

CQU:	CpipJ_CPIJ018501

CPII:

120422523

BCOO:

119069633

AME:

411906

ACER:

108002910

ALAB:

122717225

ADR:

102677819

AFLR:

100864139

BIM:

100742553

BBIF:

117212202

BVK:

117236757

BVAN:

117155624

BTER:

100644080

BAFF:

126918878

BPYO:

122577827

BPAS:

132908108

FVI:

122538519

CCAL:

108624513

OBB:

114881313

OLG:

117612008

MGEN:

117229524

NMEA:

116430221

CGIG:

122397843

SOC:

105195127

MPHA:

105830481

AEC:

105144221

ACEP:

105627042

PBAR:

105427527

VEM:

105568890

HST:

105183369

DQU:

106749629

CFO:

105255356

FEX:

115246007

LHU:

105672756

PGC:

109853314

OBO:

105280691

PCF:

106793217

PFUC:

122523891

VPS:

122629202

VCRB:

124423630

VVE:

124950253

NVI:	100122935 107981420 107981583 116415916 116415922 116416736

CSOL:

105362524

TPRE:

106650619

CGLO:

123262315

FAS:

105263324

DAM:

107045329

AGIF:

122848923

CCIN:

107272637

TCA:

663776

DPA:

109533054

SOY:

115878747

ATD:

109597721

CSET:

123309746

AGB:

108911996

LDC:

111506674

NVL:

108569827

APLN:

108741460

PPYR:

116169470

OTU:

111417657

BMOR:

101735557

BMAN:

114248506

MSEX:

115445850

DPL:	KGM_211967

BANY:

112053522

MJU:

123866136

NIQ:

126781632

VCD:

124543994

MCIX:

123670208

PMAC:

106708893

PPOT:

106100398

PXU:

106123472

PRAP:

110992850

PBX:

123714869

PNAP:

125061082

ZCE:

119833224

CCRC:

123692164

LSIN:

126973695

AAGE:

121728613

HAW:

110372275

HZE:

124632256

TNL:

113508300

SLIU:

111358317

OFU:

114365076

PXY:

105397967

PGW:

126366112

CCRN:

123291387

API:	100168226 103307719 103308720 103308751 115033073

DNX:	107167420 107169873 107170026 107170623

AGS:

114130887

RMD:

113549136

BTAB:

109030108

CLEC:

106669134

HHAL:

106691237

NLU:

111058049

HVI:

124362043

MQU:

128988710

PHU:	Phum_PHUM503290

FOC:

113204709

TPAL:

117647995

ZNE:

110835364

CSEC:

111870522

BROR:

134537745

IEL:

124162453

FCD:	110843123 110850670

DPX:	DAPPUDRAFT_329141

DMK:	116919653 123470429

DPZ:

124342260

PVM:	113818296 113827471

PJA:	122260818 122263832

PCHN:

125045839

PMOO:

119590618

HAME:

121865412

PCLA:

123762683

PTRU:

123507187

ESN:

126983052

MNZ:

135217898

HAZT:

108673820

EAF:

111714029

LSM:

121121046

TCF:

131877517

PPOI:

119091605

DSV:

119450535

RSAN:

119383577

RMP:

119170614

VDE:

111253391

VJA:

111268338

TUT:

107371540

DPTE:

113794752

DFR:

124491223

CSCU:

111636078

PTEP:

107455782

ABRU:

129958897 129983978

UDV:	129224476 129231298

SDM:

118193236

CEL:	CELE_C32D5.5(set-4)

CBR:	CBG_02629(Cbr-set-4)

CRQ:	GCK72_006228

NAI:	NECAME_12013

LOA:	LOAG_03384

HRO:	HELRODRAFT_162504

LGI:	LOTGIDRAFT_116803

PVUL:

126824206

PCAN:

112560425

BGT:

106072944

GAE:

121380962

HRF:

124135482

HRJ:

124286750

CRG:

105319029

OED:

125646750

MYI:

110457084

PMAX:

117335663

MMER:

123536245

RPHI:

132731694

DPOL:

127847528

OBI:

106875752

OSN:

115211617

LAK:	106158801 106168595

SMM:	Smp_062530

SHX:	MS3_00007460

OVI:	T265_07853

EGL:

EGR_03818

NVE:

5514661

EPA:

110245633

ATEN:

116291058

ADF:

107353716

AMIL:

114956880

PDAM:

113667740

SPIS:

111325445

DGT:

114533764

HMG:

100207998

HSY:

130613355

TAD:	TRIADDRAFT_29474

YLI:	YALI0E21802g

SLB:	AWJ20_2557

NCR:

NCU08551

NTE:	NEUTE1DRAFT82859(NEUTE1DRAFT_82859)

SMP:	SMAC_08815

PAN:	PODANSg4666

PBEL:

QC761_703820(set9)

PPSD:

QC762_703820(set9)

PPSP:

QC763_703820(set9)

PPSA:

QC764_703820(set9)

TTT:	THITE_42348

MTM:	MYCTH_73315

CTHR:

CTHT_0021730

MGR:

MGG_07393

PPEI:

PpBr36_02272

PGRI:

PgNI_02477

TMN:	UCRPA7_4749

SSCK:

SPSK_07036

FGR:	FGSG_06529

FPU:	FPSE_01728

FPOA:

FPOAC1_010233(SET9)

FVN:	FVRRES_11215

FVR:	FVEG_05617

FOX:	FOXG_02431

NHE:	NECHADRAFT_12117(SDG2118)

FFC:	NCS54_00615600

FKR:	NCS57_00654200

FMU:	J7337_002163(SET9)

TRE:	TRIREDRAFT_51287

TRR:	M419DRAFT_116228

MAW:

MAC_03332

MAJ:

MAA_07113

PCHM:

VFPPC_02548

CMT:

CCM_08113

AMUS:

LMH87_008308

PLJ:	VFPFJ_05859

PTKZ:

JDV02_000642(set9)

VAL:	VDBG_02527

VDA:	VDAG_09723

CFJ:	CFIO01_05267

CLUP:

CLUP02_04676

CHIG:

CH63R_03496

SAPO:

SAPIO_CDS1739

ELA:	UCREL1_6230

PFY:	PFICI_03652

SSL:	SS1G_08939

BFU:	BCIN_16g03730

MBE:

MBM_09131

PSCO:

LY89DRAFT_612664

GLZ:	GLAREA_07838

ANI:	ANIA_06147

AFM:	AFUA_2G08510

ACT:	ACLA_080330

NFI:	NFIA_084130

AOR:	AO090011000851

ANG:	An12g03880

AFV:	AFLA_008242

ALUC:

AKAW2_60797A(SET9)

ACHE:

ACHE_50381A(SET9)

APUU:

APUU_51081S(SET9)

PCS:	N7525_003739

PDP:	PDIP_84710

POU:	POX_f08291

TMF:	EYB26_005741

TRG:	TRUGW13939_06230

CIM:	CIMG_00843

CPW:	CPC735_054670

URE:	UREG_00803

PBL:	PAAG_07512

PBN:	PADG_11894

ABE:

ARB_04917

TVE:

TRV_05893

AJE:	HCAG_07358

BGH:	BDBG_08098

PNO:	SNOG_13760

PTE:

PTT_18535

BZE:	COCCADRAFT_27851

BSC:	COCSADRAFT_37170

BOR:	COCMIDRAFT_106770

AALT:

CC77DRAFT_17486

ARAB:

EKO05_0011221

ZTR:	MYCGRDRAFT_85175

PFJ:	MYCFIDRAFT_152998

FFU:	CLAFUR5_06045

CBET:

CB0940_08410

BCOM:

BAUCODRAFT_393590

NPA:	UCRNP2_2977

TML:	GSTUM_00001870001

CNE:

CNC03710

CNB:

CNBC3500

CNG:	CNAG_02749

CGI:	CGB_C5580C

CDEU:

CNBG_3406

TMS:	TREMEDRAFT_58833

TASA:

A1Q1_07214

CCAC:

CcaHIS019_0503730(CcaverHIS019_0503730)

PPL:	POSPLDRAFT_94935

TVS:	TRAVEDRAFT_17441

DSQ:	DICSQDRAFT_38056

PCO:	PHACADRAFT_258533

SHS:	STEHIDRAFT_35628

HIR:	HETIRDRAFT_246877

PSQ:	PUNSTDRAFT_29950

ADL:	AURDEDRAFT_19077

FME:	FOMMEDRAFT_69036

GTR:	GLOTRDRAFT_13276

LBC:	LACBIDRAFT_326385

CCI:	CC1G_11834

ABP:	AGABI1DRAFT119579(AGABI1DRAFT_119579)

ABV:	AGABI2DRAFT185465(AGABI2DRAFT_185465)

MPR:	MPER_04819

MRR:	Moror_6353

E1B28_000565

SCM:	SCHCO_02631999(SCHCODRAFT_02631999)

WSE:	WALSEDRAFT_70560

WIC:	J056_002541

UMA:	UMAG_00543

PFP:	PFL1_06099

MGL:

MGL_1066

MRT:

MRET_3089

MSYM:

MSY001_0796

PGR:	PGTG_18068

MLR:	MELLADRAFT_63110

SRE:	PTSG_09637

» show all

Reference

1 [PMID:15145825]

Authors

Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T

Title

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.

Journal

Genes Dev 18:1251-62 (2004)
DOI:10.1101/gad.300704

Sequence

[mmu:225888 232811] [dme:Dmel_CG13363]

Reference

2 [PMID:23345616]

Authors

Jorgensen S, Schotta G, Sorensen CS

Title

Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.

Journal

Nucleic Acids Res 41:2797-806 (2013)
DOI:10.1093/nar/gkt012

Reference

3 [PMID:24396869]

Authors

Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J

Title

Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.

Journal

FEBS Lett 587:3859-68 (2013)
DOI:10.1016/j.febslet.2013.10.020

Sequence

[hsa:51111 84787]

Reference

4 [PMID:24049080]

Authors

Southall SM, Cronin NB, Wilson JR

Title

A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.

Journal

Nucleic Acids Res 42:661-71 (2014)
DOI:10.1093/nar/gkt776

Sequence

[mmu:225888 232811]

Reference

5 [PMID:27105552]

Authors

Weirich S, Kudithipudi S, Jeltsch A

Title

Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates.

Journal

J Mol Biol 428:2344-2358 (2016)
DOI:10.1016/j.jmb.2016.04.015

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.362

IUBMB Enzyme Nomenclature:

2.1.1.362

ExPASy - ENZYME nomenclature database:

2.1.1.362

BRENDA, the Enzyme Database:

2.1.1.362

DBGET integrated database retrieval system