KEGG ENZYME: 2.1.1.368

ENZYME: 2.1.1.368

Entry

EC 2.1.1.368                Enzyme

Name

[histone H3]-lysine9 N-dimethyltransferase;
SUVH1 (gene name);
SUVR1 (gene name);
SET32 (gene name);
SDG32 (gene name);
SET13 (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-dimethyltransferase

Reaction(IUBMB)

2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9

Reaction(KEGG)

(other) R03875 R04866

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6-dimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9

Comment

This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.

History

EC 2.1.1.368 created 2020

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K24405

[histone H3]-lysine9 N-dimethyltransferase

Genes

ATH:	AT5G04940(SUVH1)

ALY:

9307195

CRB:

17881599

CSAT:

104708619 104734501 104768691

EUS:	EUTSA_v10012854mg EUTSA_v10015751mg

BRP:	103847241 103855596

BNA:	106382993 106428185 106440647 106445541

BOE:	106317806 106334517

RSZ:	108815877 108846741

THJ:

104816485

CPAP:

110817121

CIT:	102614065 102620879

CIC:	CICLE_v10000524mg CICLE_v10013410mg

PVY:	116126939 116138928

MINC:

123192327 123193142 123225962

TCC:

18586976

GRA:	105761557 105770657 105782469

GHI:	107904391 107935536 107938989 107954467 121217937 121223509

GAB:	108453504 108463804 108474127

HSYR:

120113849 120158017 120187638 120193093 120207980 120219103

DZI:	111295356 111296492 111311450

EGR:

104454490

GMX:	100786650 100800651 100805932 100812173 100817062

GSJ:	114376752 114387982 114399929 114406575 114409426

PVU:	PHAVU_001G103400g PHAVU_005G012600g PHAVU_011G190200g

VRA:	106753935 106761369 106772154

VAR:	108329311 108332488 108340788

VUN:	114168317 114182574

VUM:	124821065 124822596

CCAJ:

109802112 109805879 109819246 109819247 109819249

APRC:

113854756 113861242 113864324

MTR:	11414786 25488531 25501124

TPRA:

123888216 123894527 123917358

CAM:	101495955 101497613 101507703

PSAT:

127075630 127085952 127126508 127127488

VVO:	131593559 131593563 131609974 131616782 131623711 131640281

LJA:	Lj0g3v0128679.1(Lj0g3v0128679.1) Lj0g3v0266169.1(Lj0g3v0266169.1) Lj1g3v4059050.1(Lj1g3v4059050.1)

ADU:	107462763 107471926 107494232

AIP:	107604714 107613332 107622325

AHF:	112696800 112707587 112716924 112754666 112769399 112785051

LANG:

109330010 109337045 109341323 109345936 109350331 109358494

PCIN:

129296552 129306385 129313110

QSA:	O6P43_006286 O6P43_029772

FVE:	101296037 101309275

RCN:	112192455 112194774

PPER:

18770807 18785263

PMUM:

103339115 103343462

PAVI:

110746751 110763839

PDUL:

117619283 117634255 117635814

MDM:	103409193 103438644 103449908 103454698

MSYL:

126592034 126600344 126614088 126629475

PXB:	103946162 103966211

ZJU:	107412844 107415080

MNT:

21410587

CSAV:

115723191

CSV:

101218938

CMO:

103502895

BHJ:

120072888

MCHA:

111021743

CMAX:

111465944 111477770

CMOS:

111432402 111453196

CPEP:

111781305 111803325

RCU:

8276339

JCU:

105631294

HBR:	110634595 110645389

MESC:

110613379 110625627

POP:	18099790 7462819 7463781 7476804

PEU:	105122871 105132691 105136886 105137319

PALZ:

118033160 118052969 118053956 118054714

JRE:	108980180 108989442

CILL:

122291650 122294261

CAVE:

132179005 132191723

QSU:	112020905 112025017

QLO:	115952730 115983974

TWL:	119990874 119998685 120012928

VVI:	100262508 100263685

VRI:	117921131 117928570

SLY:	101243931 101258606

SPEN:

107002240 107031702

SOT:	102579046 102601580

SSTN:

125866370 125870652

SDUL:

129875537 129883009

CANN:

107844044 107864095

LBB:	132607600 132636328

NTA:	107759396 107761901(NtSet1) 107777978

NSY:	104238051 104242035

NTO:	104089131 104119054

NAU:	109207938 109242162

INI:	109158965 109161718

ITR:	116024108 116029320

SIND:

105155786 105162817

OEU:	111369292 111375319 111391199

EGT:	105959953 105976645

SSPL:

121748405 121752105 121804908 121806821

SMIL:

130987756 131003238

SHIS:

125190401 125192933

APAN:

127256689 127258690

HAN:	110884923 110898833 110940200

ECAD:

122582068 122607380

LSV:	111879372 111889461

CCAV:

112504406 112511969 112518153

DCR:	108202884 108218865 108223388

CSIN:

114269592 114276542

RVL:	131300298 131312304 131320967

AEW:	130751687 130757363 130761774 130772579 130772762 130789941 130791344

BVG:

104907436

SOE:

110778852

CQI:	110682666 110737374

ATRI:

130817305 130828362

MOF:	131145179 131166057 131166059

NNU:

104593573

MING:

122084106

TSS:	122640460 122643988

PSOM:

113310054 113322088

OSA:	4327359 4339168 4350865

DOSA:

Os01t0811300-01(Os01g0811300) Os05t0490700-01(Os05g0490700) Os11t0602200-01(Os11g0602200)

OBR:	102703881 102704160 102710125 102720563

OGL:	127754458 127773541 127779420

BDI:	100826372 100832905

ATS:	109744867 109746199 109749138 109751482

TDC:	119269346 119277343 119281805 119284650 119284655 119289024 119291505 119348763 119349242

TAES:

123062375 123065185 123066018 123071145 123079507 123079934 123084828 123093252 123098519 123137626 123142812 123182428 543460

TUA:	125522224 125526867 125545088 125552739

LPER:

127318102 127318112 127333482 127344866

LRD:	124661723 124664089 124680903 124706768 124707707 124707709

SBI:	8055276 8064166 8065992 8069112

ZMA:	100280164 541980 542085 542102

SITA:

101769814 101776606 101777191 101780099

SVS:	117843761 117851027 117852374 117857961

PVIR:

120659759 120665095 120667181 120673696 120698296 120708421

PHAI:

112880342 112886522 112892086

PDA:	103709040 103722129

EGU:

105045520

MUS:	103986232 103995163

ZOF:	121971807 121993229 121997196 122002817 122007085 122030508 122042526 122047042

DCT:	110091884 110100064

PEQ:	110024649 110027660

AOF:	109819621 109827134 109831339

MSIN:

131228172 131250552 131250554

NCOL:

116252425 116252925

ATR:

18426216

» show all

Reference

1 [PMID:15546353]

Authors

Yu Y, Dong A, Shen WH

Title

Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation.

Journal

Plant J 40:699-711 (2004)
DOI:10.1111/j.1365-313X.2004.02240.x

Sequence

[nta:107761901]

Reference

2 [PMID:15574848]

Authors

Shen WH, Meyer D

Title

Ectopic expression of the NtSET1 histone methyltransferase inhibits cell expansion, and affects cell division and differentiation in tobacco plants.

Journal

Plant Cell Physiol 45:1715-9 (2004)
DOI:10.1093/pcp/pch184

Reference

3 [PMID:15775980]

Authors

Naumann K, Fischer A, Hofmann I, Krauss V, Phalke S, Irmler K, Hause G, Aurich AC, Dorn R, Jenuwein T, Reuter G

Title

Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis.

Journal

EMBO J 24:1418-29 (2005)
DOI:10.1038/sj.emboj.7600604

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.368

IUBMB Enzyme Nomenclature:

2.1.1.368

ExPASy - ENZYME nomenclature database:

2.1.1.368

BRENDA, the Enzyme Database:

2.1.1.368

DBGET integrated database retrieval system