KEGG ENZYME: 2.1.1.373

ENZYME: 2.1.1.373

Entry

EC 2.1.1.373                Enzyme

Name

2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase;
dsyB (gene name);
methylthiohydroxybutyrate methyltransferase;
MTHB methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(2R)-2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate = S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate [RN:R12666]

Reaction(KEGG)

R12666

Substrate

S-adenosyl-L-methionine [CPD:C00019];
(2R)-2-hydroxy-4-(methylsulfanyl)butanoate [CPD:C22315]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate [CPD:C22316]

Comment

The enzyme, characterized from the marine bacterium Labrenzia aggregata, participates in the biosynthesis of dimethylsulfoniopropanoate (DMSP). A eukaryotic enzyme that shares little sequence similarity with the bacterial enzyme was identified in many marine phytoplankton species.

History

EC 2.1.1.373 created 2020

Orthology

K24666

2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase

Genes

HOE:	IMCC20628_04415

BRN:	D1F64_17375

RBM:

TEF_00930

LAP:	ACP90_07270

LABR:

CHH27_12955

LABP:

FJ695_11515

LABT:

FIU93_12925(crtF)

LAGG:

B0E33_19335

SIW:	GH266_11265

ACUT:

MRB58_17945

RED:	roselon_03022

YAN:	AYJ57_15890

TPRO:

Ga0080559_TMP4718

PABY:

Ga0080574_TMP997

RID:	RIdsm_02262(crtF_2)

AHT:	ANTHELSMS3_02971

SAGU:

CDO87_12755

OCD:	FHY55_10290

ROT:	FIV09_08250(crtF1)

MALU:

KU6B_20890

TGL:	HFZ77_02600

PALX:

GQA70_12270

RHC:

RGUI_3553

PPRU:

FDP22_08505

PALW:

PSAL_008650(aziB2)

PSHQ:

F3W81_04580

NACI:

NUH88_05915

THAR:

T8K17_10035

RANT:

RHODO2019_06505

SCAL:

I6J39_29690

» show all

Reference

Authors

Summers, P.S., Nolte, K.D., Cooper, A.J.L., Borgeas, H., Leustek, T., Rhodes, D. and Hanson, A.D.

Title

Identification and stereospecificity of the first three enzymes of 3-dimethylsulfoniopropionate biosynthesis in a chlorophyte alga.

Journal

Plant Physiol 116:369-378 (1998)

Reference

2 [PMID:28191900]

Authors

Curson AR, Liu J, Bermejo Martinez A, Green RT, Chan Y, Carrion O, Williams BT, Zhang SH, Yang GP, Bulman Page PC, Zhang XH, Todd JD.

Title

Dimethylsulfoniopropionate biosynthesis in marine bacteria and identification of the key gene in this process.

Journal

Nat Microbiol 2:17009 (2017)
DOI:10.1038/nmicrobiol.2017.9

Sequence

[lagg:B0E33_19335]

Reference

3 [PMID:29574051]

Authors

Kageyama H, Tanaka Y, Shibata A, Waditee-Sirisattha R, Takabe T.

Title

Dimethylsulfoniopropionate biosynthesis in a diatom Thalassiosira pseudonana: Identification of a gene encoding MTHB-methyltransferase.

Journal

Arch Biochem Biophys 645:100-106 (2018)
DOI:10.1016/j.abb.2018.03.019

Sequence

[tps:THAPSDRAFT_269095]

Reference

4 [PMID:29483657]

Authors

Curson ARJ, Williams BT, Pinchbeck BJ, Sims LP, Martinez AB, Rivera PPL, Kumaresan D, Mercade E, Spurgin LG, Carrion O, Moxon S, Cattolico RA, Kuzhiumparambil U, Guagliardo P, Clode PL, Raina JB, Todd JD.

Title

DSYB catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton.

Journal

Nat Microbiol 3:430-439 (2018)
DOI:10.1038/s41564-018-0119-5

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.373

IUBMB Enzyme Nomenclature:

2.1.1.373

ExPASy - ENZYME nomenclature database:

2.1.1.373

BRENDA, the Enzyme Database:

2.1.1.373

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (304)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (30)   
   KEGG MGENES (273)   
All databases (309)   

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