Entry Name glycine betaine---corrinoid protein Co-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname glycine betaine:[Co(I) glycine betaine-specific corrinoid protein] Co-methyltransferase
Reaction(IUBMB) glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] = N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein] [RN:
R12787 ]
Reaction(KEGG) Substrate glycine betaine [CPD:
C00719 ];
[Co(I) glycine betaine-specific corrinoid protein]
Product N,N-dimethylglycine [CPD:
C01026 ];
[methyl-Co(III) glycine betaine-specific corrinoid protein]
Comment The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine.
History EC 2.1.1.376 created 2021
Pathway ec00260 Glycine, serine and threonine metabolism
Orthology K25220 glycine betaine---corrinoid protein Co-methyltransferase
Genes FWA : DCMF_23125 DCMF_26765
AACX : DEACI_1208 DEACI_1210 DEACI_1255 DEACI_1256 DEACI_1266 DEACI_1268 DEACI_1278 DEACI_1681 DEACI_4248
BLIQ : INP51_05155 INP51_12235 INP51_14665
BLAR : LC508_08010 LC508_08055 LC508_10695 LC508_14925 LC508_22935 LC508_25320 LC508_25335
BCOC : BLCOC_17010(mtgB_1) BLCOC_22790(mtgB_2) BLCOC_22880(mtgB_3) BLCOC_43120(mtgB_5) BLCOC_43160(mtgB_6)
WHJ : H9Q79_07380 H9Q79_08790 H9Q79_08880 H9Q79_14845
ETM : CE91St48_00670(mttB_1) CE91St48_00770 CE91St48_05970 CE91St48_09680 CE91St48_13000 CE91St48_22250(mttB_3) CE91St48_22260(mttB_4) CE91St48_31720 CE91St48_31730(mttB_5)
TEB : T8CH_0245 T8CH_0486 T8CH_1979 T8CH_2735 T8CH_2737
THYR : P4S50_05620 P4S50_14775
NCD : ACONDI_01179 ACONDI_01398 ACONDI_01399 ACONDI_01401 ACONDI_02393 ACONDI_03100
AAR : Acear_1049 Acear_1222
STED : SPTER_06970(mtgB_3)
CALK : HUE98_00750 HUE98_00760 HUE98_08960
ALAM : RT761_00980 RT761_01750
MEHF : MmiHf6_10000(mtgB_2)
MEES : MmiEs2_13280(mtgB_1) MmiEs2_13340(mtgB_3)
» show all Taxonomy Reference Authors Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.
Title A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.
Journal Sequence Reference Authors Creighbaum AJ, Ticak T, Shinde S, Wang X, Ferguson DJ Jr.
Title Examination of the Glycine Betaine-Dependent Methylotrophic Methanogenesis Pathway: Insights Into Anaerobic Quaternary Amine Methylotrophy.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.376
