| Entry |
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| Name |
3-amino-4-hydroxybenzoate 4-O-methyltransferase;
creN (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:3-amino-4-hydroxybenzoate 4-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3-amino-2,4-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-amino-2-hydroxy-4-methoxybenzoate [RN: R12928]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
3-amino-2,4-dihydroxybenzoate [CPD: C22455]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
3-amino-2-hydroxy-4-methoxybenzoate [CPD: C22425]
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| Comment |
The enzyme, characterized from the bacterium Streptomyces cremeus, is involved in cremeomycin biosynthesis.
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| History |
EC 2.1.1.380 created 2021
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| Pathway |
| ec00998 | Biosynthesis of various antibiotics |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K25594 | 3-amino-4-hydroxybenzoate 4-O-methyltransferase |
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| Genes |
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| Reference |
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| Authors |
Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP. |
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| Title |
The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.380 |
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