Entry Name arginine Nomega-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:L-arginine Nomega-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + L-arginine = S-adenosyl-L-homocysteine + Nomega-methyl-L-arginine [RN:
R12929 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
L-arginine [CPD:
C00062 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
Nomega-methyl-L-arginine
Comment The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, participates in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin.
History EC 2.1.1.381 created 2021
Orthology K25595 arginine Nomega-methyltransferase
Genes » show all Taxonomy Reference Authors Ng TL, Rohac R, Mitchell AJ, Boal AK, Balskus EP.
Title An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin.
Journal Sequence Reference Authors He HY, Henderson AC, Du YL, Ryan KS.
Title Two-Enzyme Pathway Links l-Arginine to Nitric Oxide in N-Nitroso Biosynthesis.
Journal Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.381
