Entry Name L-carnitine---corrinoid protein Co-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname L-carnitine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase
Reaction(IUBMB) L-carnitine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + L-norcarnitine [RN:
R12930 ]
Reaction(KEGG) Substrate L-carnitine [CPD:
C00318 ];
[Co(I) quaternary-amine-specific corrinoid protein]
Product [methyl-Co(III) quaternary-amine-specific corrinoid protein];
L-norcarnitine [CPD:
C22426 ]
Comment The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-carnitine to tetrahydrofolate, as part of an L-carnitine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway.
History EC 2.1.1.383 created 2021
Orthology K25600 L-carnitine---corrinoid protein Co-methyltransferase
Genes Taxonomy Reference Authors Kountz DJ, Behrman EJ, Zhang L, Krzycki JA.
Title MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.383
