KEGG   ENZYME: 2.1.1.385
Entry
EC 2.1.1.385                Enzyme                                 
Name
[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase;
mtvA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
[methylated methoxylated-aromatic-compound-specific corrinoid protein]:tetrahydrofolaten methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) methoxylated-aromatic-compound-specific corrinoid protein] [RN:R02289]
Reaction(KEGG)
R02289
Substrate
[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein];
tetrahydrofolate [CPD:C00101]
Product
N5-methyltetrahydrofolate;
[Co(I) methoxylated-aromatic-compound-specific corrinoid protein]
Comment
The enzyme, found in acetogenic bacteria, participates in a pathway for the degradation of methoxylated aromatic compounds (methoxydotrophic growth). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (MtvC) to tetrahydrofolate. cf. EC 2.1.1.384, [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydromethanopterin methyltransferase.
History
EC 2.1.1.385 created 2022
Pathway
ec00670  One carbon pool by folate
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
Orthology
K25915  [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase
Genes
DOR: Desor_3940
DAI: Desaci_1203
DMI: Desmer_3054
AACX: DEACI_1429
TPZ: Tph_c01810
MTA: Moth_0385 Moth_1318
MTHO: MOTHE_c13030(acsE4)
MTHZ: MOTHA_c04100(acsE1) MOTHA_c13890(acsE4)
Reference
1  [PMID:9654069]
  Authors
Kaufmann F, Wohlfarth G, Diekert G.
  Title
O-demethylase from Acetobacterium dehalogenans--substrate specificity and function of the participating proteins.
  Journal
Eur J Biochem 253:706-11 (1998)
DOI:10.1046/j.1432-1327.1998.2530706.x
Reference
2  [PMID:11344134]
  Authors
Naidu D, Ragsdale SW.
  Title
Characterization of a three-component vanillate O-demethylase from Moorella thermoacetica.
  Journal
J Bacteriol 183:3276-81 (2001)
DOI:10.1128/JB.183.11.3276-3281.2001
Reference
3  [PMID:18631365]
  Authors
Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW
  Title
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).
  Journal
Environ Microbiol 10:2550-73 (2008)
DOI:10.1111/j.1462-2920.2008.01679.x
  Sequence
[mta:Moth_0385 Moth_1318]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.385
IUBMB Enzyme Nomenclature: 2.1.1.385
ExPASy - ENZYME nomenclature database: 2.1.1.385
BRENDA, the Enzyme Database: 2.1.1.385

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG REACTION (1)   
   KEGG RCLASS (3)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10)   
All databases (26)   

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