Entry
Name
proline betaine---corrinoid protein Co-methyltransferase;
mtpB (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
L-proline betaine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase
Reaction(IUBMB)
L-proline betaine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + N-methyl-L-proline [RN:
R13185 ]
Reaction(KEGG)
Substrate
L-proline betaine [CPD:
C10172 ];
[Co(I) quaternary-amine-specific corrinoid protein]
Product
[methyl-Co(III) quaternary-amine-specific corrinoid protein];
N-methyl-L-proline [CPD:
C22223 ]
Comment
The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-proline betaine to tetrahydrofolate, as part of an L-proline betaine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway.
History
EC 2.1.1.388 created 2023
Orthology
K26847 proline betaine --- corrinoid protein Co-methyltransferase
Genes
Taxonomy
Reference
Authors
Picking JW, Behrman EJ, Zhang L, Krzycki JA.
Title
MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.388