Entry Name [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase;
Class Transferases;BRITE hierarchy
Sysname [methyl-Co(III) quaternary-amine-specific corrinoid protein]:tetrahydrofolate methyltransferase
Reaction(IUBMB) a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) quaternary-amine-specific corrinoid protein] [RN:
R02289 ]
Reaction(KEGG) Substrate [methyl-Co(III) quaternary-amine-specific corrinoid protein];
tetrahydrofolate [CPD:
C00101 ]
Product N5-methyltetrahydrofolate;
Comment The enzyme, characterized from the acetogenic gut bacterium Eubacterium limosum, participates in a pathway for the degradation of some quaternary amine compounds (L-proline betaine and L-carnitine). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (bacterial MtqC) to tetrahydrofolate. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway.
History EC 2.1.1.389 created 2023
Pathway ec00720 Carbon fixation pathways in prokaryotes
Orthology K26930 [methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase
Genes BLAR : LC508_19345 LC508_27400
BCOC : BLCOC_00750(acsE_1)
Taxonomy Reference Authors Picking JW, Behrman EJ, Zhang L, Krzycki JA.
Title MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation.
Journal Sequence Reference Authors Kountz DJ, Behrman EJ, Zhang L, Krzycki JA.
Title MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.389
