Entry
Name
indolepyruvate C-methyltransferase;
ind1 (gene name);
indolepyruvate methyltransferase;
indolepyruvate 3-methyltransferase;
indolepyruvic acid methyltransferase;
S-adenosyl-L-methionine:indolepyruvate C-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(indol-3-yl)pyruvate C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (R)-3-(indol-3-yl)-2-oxobutanoate [RN:
R01972 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
(indol-3-yl)pyruvate [CPD:
C00331 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
(R)-3-(indol-3-yl)-2-oxobutanoate [CPD:
C21289 ]
Comment
The enzyme, characterized from the bacterium Streptomyces griseus, is involved in the biosynthesis of the antibacterial drug indolmycin.
History
EC 2.1.1.47 created 1976, modified 2016
Pathway
Orthology
K22590 indolepyruvate C-methyltransferase
Reference
Authors
Hornemann U, Speedie MK, Hurley LH, Floss HG.
Title
Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus.
Journal
Reference
Authors
Hornemann U, Hurley LH, Speedie MK, Floss HG
Title
The biosynthesis of indolmycin.
Journal
Reference
Authors
Speedie MK, Hornemann U, Floss HG
Title
Isolation and characterization of tryptophan transaminase and indolepyruvate C-methyltransferase. Enzymes involved in indolmycin biosynthesis in Streptomyces griseus.
Journal
J Biol Chem 250:7819-25 (1975)
Reference
Authors
Du YL, Alkhalaf LM, Ryan KS
Title
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.47
ExPASy - ENZYME nomenclature database: 2.1.1.47