KEGG   ENZYME: 2.1.1.84
Entry
EC 2.1.1.84                 Enzyme                                 
Name
methylquercetagetin 6-O-methyltransferase;
flavonol 6-O-methyltransferase;
flavonol 6-methyltransferase;
6-OMT;
S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone [RN:R04505]
Reaction(KEGG)
R04505
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5,3',4'-trihydroxy-3,6,7-trimethoxyflavone
Comment
The enzymes from Chrysosplenium americanum also methylates 3,7,3'-trimethylquercetagetin at the 6-position. Does not act on flavones, dihydroflavonols, or their glucosides.
History
EC 2.1.1.84 created 1989
Reference
1  [PMID:3994393]
  Authors
De Luca V, Ibrahim RK
  Title
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases.
  Journal
Arch Biochem Biophys 238:596-605 (1985)
DOI:10.1016/0003-9861(85)90205-X
Reference
2  [PMID:3994394]
  Authors
De Luca V, Ibrahim RK.
  Title
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases.
  Journal
Arch Biochem Biophys 238:606-18 (1985)
DOI:10.1016/0003-9861(85)90206-1
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.84
IUBMB Enzyme Nomenclature: 2.1.1.84
ExPASy - ENZYME nomenclature database: 2.1.1.84
BRENDA, the Enzyme Database: 2.1.1.84
CAS: 97089-68-4

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (8)   

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