KEGG ENZYME: 2.1.1.90

ENZYME: 2.1.1.90

Entry

EC 2.1.1.90                 Enzyme

Name

methanol---corrinoid protein Co-methyltransferase;
methanol cobalamin methyltransferase;
methanol:5-hydroxybenzimidazolylcobamide methyltransferase;
MT 1 (ambiguous);
methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase;
mtaB (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase

Reaction(IUBMB)

methanol + a [Co(I) methanol-specific corrinoid protein] = a [methyl-Co(III) methanol-specific corrinoid protein] + H2O [RN:R04384]

Reaction(KEGG)

R04384;
(other) R09098

Substrate

methanol [CPD:C00132];
[Co(I) methanol-specific corrinoid protein]

Product

[methyl-Co(III) methanol-specific corrinoid protein];
H2O [CPD:C00001]

Comment

The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2].
Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.

History

EC 2.1.1.90 created 1989, modified 2012

Pathway

ec00680

Methane metabolism

ec01120

Microbial metabolism in diverse environments

Orthology

K04480

methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase

Genes

DSX:	GD604_09795

DTI:	Desti_2034

CFM:	BJL90_02615

CCL:	Clocl_0783

DOR:	Desor_2803

DMI:	Desmer_2205

DKU:	Desku_0051

FWA:	DCMF_12970

TJR:	TherJR_0987

ELM:

ELI_2003

EMT:	CPZ25_002645

ELIM:

B2M23_16850

AWO:	Awo_c22760(mttB18)

ANR:	Ana3638_17590

VPY:	HZI73_06080

IBR:	NQ514_08270

TPZ:	Tph_c03590(mtaB)

MTA:

Moth_1209

MTHO:

MOTHE_c11860

MTHZ:

MOTHA_c12720

MANA:

MAMMFC1_02497

STED:

SPTER_30470

ALUS:

STSP2_00335

FSH:	Q2T83_17060

MST:	Msp_0184(mtaB3) Msp_0186(mtaB2) Msp_0188(mtaB1) Msp_0819(mtaB4)

METB:

AW729_03460 AW729_06185

MEIS:

PXD04_04795 PXD04_04805 PXD04_09505

MSI:

Msm_0515

MARO:

MarbSA_04050

METV:

K4897_03085

MEL:	Metbo_1023

MEW:	MSWAN_1082

MCUB:

MCBB_1154(mtaB)

MBA:	Mbar_A0741 Mbar_A1064 Mbar_A3638

MBY:	MSBRM_0302 MSBRM_2353 MSBRM_3321

MBW:	MSBRW_0261 MSBRW_1094 MSBRW_3658

MBAR:

MSBR2_2078 MSBR2_2319 MSBR2_3275

MBAK:

MSBR3_2096 MSBR3_2380 MSBR3_3273

MAC:	MA_0455(mtaB1) MA_1616(mtaB3) MA_4392(mtaB2)

MMA:	MM_0175(mtaB) MM_1074(mtaB) MM_1647

MMAZ:

MmTuc01_0182 MmTuc01_1725

MMJ:	MSMAS_0227 MSMAS_1126 MSMAS_3023

MMAC:

MSMAC_0233 MSMAC_1415 MSMAC_2486

MVC:	MSVAZ_0210 MSVAZ_0343 MSVAZ_1365

MEK:	MSKOL_0204 MSKOL_0326 MSKOL_1308

MLS:	MSLAZ_0239 MSLAZ_1380 MSLAZ_2955

METM:

MSMTP_0258 MSMTP_1140 MSMTP_2926

MEF:	MSWH1_0315 MSWH1_0524 MSWH1_1022

MEQ:	MSWHS_0318 MSWHS_0538 MSWHS_1093

MSJ:	MSSAC_0405 MSSAC_1598 MSSAC_4075

MSZ:	MSSIH_0373 MSSIH_1187 MSSIH_3611

MSW:	MSSIT_0381 MSSIT_1254 MSSIT_3664

MTHR:

MSTHT_0083 MSTHT_1750 MSTHT_2137

MTHE:

MSTHC_0647 MSTHC_1146 MSTHC_1539

MHOR:

MSHOH_0282 MSHOH_1348 MSHOH_3746

MFZ:	AOB57_002020 AOB57_005220 AOB57_007940

MBU:	Mbur_0812 Mbur_0814

MMET:

MCMEM_0944 MCMEM_0947 MCMEM_0949

MELO:

J7W08_02955 J7W08_02965

MMH:	Mmah_0976 Mmah_0978

MHAZ:

BHR79_08685 BHR79_08695

MPOT:

BKM01_04955 BKM01_04965

MEV:	Metev_0944

MZH:	Mzhil_1950 Mzhil_1952

MPY:	Mpsy_0909 Mpsy_3036

MZI:	HWN40_04050 HWN40_07075

MMAV:

RE476_03440(mtaB) RE476_06200(mtaB)

MSEB:

RE474_02330(mtaB) RE474_13090(mtaB)

MHZ:	Metho_0775 Metho_1601

MEHF:

MmiHf6_11430 MmiHf6_11480

MEES:

MmiEs2_14110 MmiEs2_14160

RCI:	RCIX1974(mtaB)

MEAM:

MU439_02355

MEAE:

QEN48_01760 QEN48_07915

MAX:	MMALV_09470

MER:	MMINT_02820 MMINT_03160 MMINT_05920

MEAR:

Mpt1_c05090(mtaB)

MEUZ:

KRP56_04440 KRP56_04450

MARC:

AR505_0949 AR505_0951

» show all

Reference

1 [PMID:6438059]

Authors

van der Meijden P, te Brommelstroet BW, Poirot CM, van der Drift C, Vogels GD.

Title

Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri.

Journal

J Bacteriol 160:629-35 (1984)
DOI:10.1128/JB.160.2.629-635.1984

Sequence

[mba:Mbar_A0741]

Reference

2 [PMID:10215883]

Authors

Sauer K, Thauer RK

Title

Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.

Journal

Eur J Biochem 261:674-81 (1999)
DOI:10.1046/j.1432-1327.1999.00355.x

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.90

IUBMB Enzyme Nomenclature:

2.1.1.90

ExPASy - ENZYME nomenclature database:

2.1.1.90

BRENDA, the Enzyme Database:

2.1.1.90

CAS:	86611-98-5

DBGET integrated database retrieval system