KEGG   ENZYME: 2.1.2.14
Entry
EC 2.1.2.14                 Enzyme                                 
Name
GDP-perosamine N-formyltransferase;
wbkC (gene name)
Class
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
Sysname
10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase
Reaction(IUBMB)
10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine [RN:R12790]
Reaction(KEGG)
R12790
Substrate
10-formyltetrahydrofolate [CPD:C00234];
GDP-alpha-D-perosamine [CPD:C20638]
Product
tetrahydrofolate [CPD:C00101];
GDP-N-formyl-alpha-D-perosamine [CPD:C22397]
Comment
The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species.
History
EC 2.1.2.14 created 2021
Pathway
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K00607  GDP-perosamine N-formyltransferase
Genes
ASAL: CFBP5507_25610
BME: BMEI1418
BMEL: DK63_2070
BMI: BMEA_A0555
BMZ: BM28_A0534
BMG: BM590_A0536
BMW: BMNI_I0525
BMEE: DK62_884
BMF: BAB1_0540
BMB: BruAb1_0540
BMC: BAbS19_I05060
BAA: BAA13334_I03106
BABO: DK55_547
BABR: DO74_1339
BABT: DK49_311
BABB: DK48_1578
BABU: DK53_537
BABS: DK51_923
BABC: DO78_454
BMS: BR0517
BSI: BS1330_I0516
BSF: BSS2_I0504
BSUI: BSSP1_I1186
BSUP: BSPT1_I1197
BSUV: BSPT2_I1182
BSUC: BSSP2_I0533
BMT: BSUIS_A0548(arnA)
BSZ: DK67_1446
BSV: BSVBI22_A0516
BSW: IY71_02635
BSG: IY72_02360
BOV: BOV_0521
BCS: BCAN_A0529(arnA)
BSK: BCA52141_I0862
BOL: BCOUA_I0517
BCAR: DK60_600
BCAS: DA85_02475
BMR: BMI_I519
BPP: BPI_I548
BPV: DK65_842
BVL: BF3285c1_0240
BRU: BFS01_02560
CNV: CNZW441b_1265
TMUR: JBF11_02245
NBN: HYY55_00050
 » show all
Reference
1  [PMID:11081580]
  Authors
Godfroid F, Cloeckaert A, Taminiau B, Danese I, Tibor A, de Bolle X, Mertens P, Letesson JJ.
  Title
Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of brucella melitensis 16M (wbk).
  Journal
Res Microbiol 151:655-68 (2000)
DOI:10.1016/s0923-2508(00)90130-x
  Sequence
[bme:BMEI1418]
Reference
2  [PMID:28636341]
  Authors
Riegert AS, Chantigian DP, Thoden JB, Tipton PA, Holden HM.
  Title
Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis.
  Journal
Biochemistry 56:3657-3668 (2017)
DOI:10.1021/acs.biochem.7b00494
  Sequence
[bme:BMEI1418]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.2.14
IUBMB Enzyme Nomenclature: 2.1.2.14
ExPASy - ENZYME nomenclature database: 2.1.2.14
BRENDA, the Enzyme Database: 2.1.2.14

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (45)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (44)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (2)   
   InterPro (2)   
All databases (61)   

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