| Entry |
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| Name |
decarbamoylnovobiocin carbamoyltransferase;
novN (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
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| Sysname |
carbamoyl phosphate:decarbamoylnovobiocin 3''-O-carbamoyltransferase
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| Reaction(IUBMB) |
carbamoyl phosphate + decarbamoylnovobiocin = phosphate + novobiocin [RN: R06772]
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| Reaction(KEGG) |
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| Substrate |
carbamoyl phosphate [CPD: C00169];
decarbamoylnovobiocin [CPD: C12476]
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| Product |
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| Comment |
The enzyme catalyses the last step in the biosynthesis of the aminocoumarin antibiotic novobiocin. The reaction is activated by ATP [1].
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| History |
EC 2.1.3.12 created 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K12713 | decarbamoylnovobiocin carbamoyltransferase |
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| Genes |
| SNEP: | Enr13x_07980(novN_1) |
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| Reference |
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| Authors |
Freel Meyers CL, Oberthur M, Xu H, Heide L, Kahne D, Walsh CT |
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| Title |
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gomez Garcia I, Freel Meyers CL, Walsh CT, Lawson DM |
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| Title |
Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.3.12 |
| ExPASy - ENZYME nomenclature database: | 2.1.3.12 |
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