Entry Name sesamin methylene transferase;
Class Transferases;BRITE hierarchy
Sysname (+)-sesamin:tetrahydrofolate N-methylenetransferase
Reaction(IUBMB) (1) (+)-sesamin + tetrahydrofolate = (+)-demethylpiperitol + 5,10-methylenetetrahydrofolate [RN:
R11955 ];
(2) (+)-demethylpiperitol + tetrahydrofolate = (+)-didemethylpinoresinol + 5,10-methylenetetrahydrofolate [RN:
R11956 ]
Reaction(KEGG) Substrate (+)-sesamin [CPD:
C10882 ];
tetrahydrofolate [CPD:
C00101 ];
(+)-demethylpiperitol [CPD:
C21801 ]
Product (+)-demethylpiperitol [CPD:
C21801 ];
5,10-methylenetetrahydrofolate [CPD:
C00143 ];
(+)-didemethylpinoresinol [CPD:
C21802 ]
Comment This enzyme was characterized from the bacterium Sinomonas sp. No.22. It catalyses a cleavage of a methylene bridge, followed by the transfer of the methylene group to tetrahydrofolate. The enzyme is also active with (+)-episesamin, (-)-asarinin, (+)-sesaminol, (+)-sesamolin, and piperine.
History EC 2.1.5.1 created 2018
Orthology K22578 sesamin methylene transferase
Reference Authors Kumano T, Fujiki E, Hashimoto Y, Kobayashi M
Title Discovery of a sesamin-metabolizing microorganism and a new enzyme.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 2.1.5.1
ExPASy - ENZYME nomenclature database: 2.1.5.1
BRENDA, the Enzyme Database: 2.1.5.1
