KEGG   ENZYME: 2.3.1.177
Entry
EC 2.3.1.177                Enzyme                                 
Name
3,5-dihydroxybiphenyl synthase;
BIS1;
biphenyl synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:benzoyl-CoA malonyltransferase
Reaction(IUBMB)
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 [RN:R09621]
Reaction(KEGG)
R09621
Substrate
malonyl-CoA [CPD:C00083];
benzoyl-CoA [CPD:C00512]
Product
CoA [CPD:C00010];
3,5-dihydroxybiphenyl [CPD:C19750];
CO2 [CPD:C00011]
Comment
A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase.
History
EC 2.3.1.177 created 2006, modified 2012
Orthology
K21384  3,5-dihydroxybiphenyl/4-hydroxycoumarin synthase
Genes
FVE101312122 101312413
RCN112169554 112173282
PPER109948444 18780920 18781256
PMUM103326884 103326885
PAVI110755238
PDUL117624590
MDM103418590 103455021 103456249 103456250 114819163
MSYL126598538 126601534 126601535 126605162 126605164
PXB103945211 103945212 103946755 103946756 103946757 103946758 103946760 103946761
Reference
1  [PMID:14595561]
  Authors
Liu B, Beuerle T, Klundt T, Beerhues L
  Title
Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia.
  Journal
Planta 218:492-6 (2004)
DOI:10.1007/s00425-003-1144-y
  Sequence
Reference
2  [PMID:17109150]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
Biphenyl synthase, a novel type III polyketide synthase.
  Journal
Planta 225:1495-503 (2007)
DOI:10.1007/s00425-006-0435-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.177
IUBMB Enzyme Nomenclature: 2.3.1.177
ExPASy - ENZYME nomenclature database: 2.3.1.177
BRENDA, the Enzyme Database: 2.3.1.177
CAS: 1217551-24-0

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