Entry
Name
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:desacetylmycothiol O-acetyltransferase
Reaction(IUBMB)
desacetylmycothiol + acetyl-CoA = CoA + mycothiol [RN:
R09622 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium [1]. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) [2]. The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate [3].
History
EC 2.3.1.189 created 2010
Orthology
Genes
CSUA : IM538_08335 IM538_22940
BVQ : FHE72_12810 FHE72_17820
PSON : JI735_21895 JI735_25300
PBK : Back11_32640 Back11_36870
PRZ : GZH47_24545 GZH47_29130 GZH47_32110
CARG : RSJ17_09875 RSJ17_10065
EUZ : DVS28_a0394 DVS28_a4803
MMAE : MMARE11_46720(mshD)
MBAI : MB901379_04255(mshD)
MHEK : JMUB5695_00654(mshD)
MKY : IWGMT90018_55470(mshD)
MPHL : MPHLCCUG_00716(mshD_1)
MTHN : 4412656_03920(mshD)
MCHT : MCHIJ_21810(mshD) MCHIJ_50720
MAUU : NCTC10437_04856(mshD)
MFLV : NCTC10271_00667(mshD)
MSAL : DSM43276_00664(mshD_1)
MTER : 4434518_03510(mshD)
CDIP : ERS451417_01932(mshD)
COI : CPCIP5297_08900(mshD)
CUN : Cul210932_1905(mshD2)
CUQ : Cul210931_1799(mshD2)
CUZ : Cul05146_1896(mshD2)
CUJ : CUL131002_1823c(mshD2)
CUS : CulFRC11_1801(mshD2)
CMIN : NCTC10288_00413(mshD)
CRL : NCTC7448_00371(mshD)
CCYS : SAMEA4530656_0247(mshD)
CAUI : CAURIS_09240(mshD1)
CAUS : CAURIC_02385(mshD2)
NFR : ERS450000_03621(mshD)
NNO : NONO_c06230(mshD) NONO_c50940
NAD : NCTC11293_01376(mshD)
NWL : NWFMUON74_06120(mshD)
NSPU : IFM12276_03120(mshD)
ROP : ROP_17780 ROP_49430(mshD)
RAV : AAT18_05290 AAT18_05645
RCR : NCTC10994_01920(mshD)
RANT : RHODO2019_00795(mshD)
GTA : BCM27_18905 BCM27_20265
GRU : GCWB2_03215(mshD2) GCWB2_19765(mshD5)
GOM : D7316_02318(mshD_2) D7316_04317(mshD_4)
GAV : C5O27_01815 C5O27_08360(mshD)
TPUL : TPB0596_38570(mshD)
SGRF : SGFS_056950 SGFS_096890
SCYE : R2B67_16390(mshD) R2B67_25075
SCB : SCAB_11421 SCAB_49481
SSX : SACTE_3588 SACTE_6500
SDV : BN159_0931 BN159_4782(mshD)
SALS : SLNWT_4051 SLNWT_4356 SLNWT_7050
STRP : F750_0247 F750_3895(mshD)
STRE : GZL_04118 GZL_08037
STRM : M444_16600 M444_22345
SAMB : SAM23877_3532(mshD)
SPRI : SPRI_2761 SPRI_4005
STRF : ASR50_03585 ASR50_18020
SLE : sle_38040(sle_38040)
SRN : A4G23_00317(mshD_1) A4G23_02540(mshD_3)
SPAV : Spa2297_01260 Spa2297_15420
SCLF : BB341_08835 BB341_12725
SGS : AVL59_21075 AVL59_45565
SKY : D0C37_14860(mshD) D0C37_28420
SALW : CP975_04580 CP975_16460(mshD)
SGM : GCM10017557_39210(mshD)
SCAD : DN051_21155(mshD) DN051_41180
SPHW : NFX46_14960 NFX46_38435(mshD)
SLS : SLINC_0146 SLINC_0343 SLINC_3975
SNR : SNOUR_18295(mshD) SNOUR_33990
SALU : DC74_1750 DC74_4724
SALL : SAZ_09295 SAZ_25195
SPLU : LK06_017490 LK06_031245
STRD : NI25_21135 NI25_35710
SSIA : A7J05_19125 A7J05_30485
SVU : B1H20_08975 B1H20_18865
SPUN : BFF78_03215 BFF78_22755
SALF : SMD44_01023 SMD44_03966
SLX : SLAV_14035(mshD2) SLAV_17920(mshD3) SLAV_37605
STRO : STRMOE7_02755 STRMOE7_22685
SNZ : DC008_02305 DC008_16055(mshD)
SGE : DWG14_00782(mshD_1) DWG14_04540(mshD_7) DWG14_08192(mshD_14)
SGD : ELQ87_20585(mshD) ELQ87_22650
SQZ : FQU76_15025(mshD) FQU76_22695
SCYA : EJ357_02205 EJ357_21365(mshD)
SAST : CD934_01090 CD934_13910(mshD)
STIR : DDW44_06585(mshD) DDW44_29550 DDW44_31155
SKA : CP970_03735 CP970_23245(mshD) CP970_37980
SGZ : C0216_04525 C0216_29225(mshD)
SVN : CP980_12070 CP980_18260(mshD) CP980_34320
SFIC : EIZ62_17545(mshD) EIZ62_31285
SGAL : CP966_16980(mshD) CP966_33355
SSPO : DDQ41_00505 DDQ41_14360(mshD)
SAQU : EJC51_05135 EJC51_23455(mshD)
SGF : HEP81_04129(mshD) HEP81_07337
SRIM : CP984_00760 CP984_16415(mshD)
SSUB : CP968_12230 CP968_18255(mshD)
SPHV : F9278_22070(mshD) F9278_42585
SPAC : B1H29_19970 B1H29_34715
STSU : B7R87_14620 B7R87_22455
SCHA : CP983_02240 CP983_22875(mshD)
SBAT : G4Z16_09405 G4Z16_18645(mshD)
SNF : JYK04_04127(mshD_7) JYK04_05472(mshD_11)
SBRO : GQF42_21580(mshD) GQF42_42555
STUI : GCM10017668_32390(mshD)
SHUN : DWB77_03666(mshD_4)
SFEU : IM697_02855(mshD) IM697_21295
SCAL : I6J39_09260 I6J39_18700(mshD)
SFB : CP974_01660 CP974_13835(mshD)
SPEU : CGZ69_16680(mshD) CGZ69_23075
SROI : IAG44_22235(mshD) IAG44_37720
SGJ : IAG43_14465(mshD) IAG43_20880
SMAO : CAG99_05230 CAG99_15340
SGOB : test1122_10725(mshD)
SDEC : L3078_21400(mshD) L3078_39800
SAOV : G3H79_19760(mshD) G3H79_33930
SDUR : M4V62_02810 M4V62_22925(mshD)
SYAN : NRK68_15770(mshD) NRK68_22230
SAKB : K1J60_04020 K1J60_23585(mshD) K1J60_37655
SVIO : HWN34_16920(mshD) HWN34_26650
SCAE : IHE65_04940 IHE65_24140(mshD) IHE65_40490
SCIR : STRCI_003873(mshD) STRCI_007503
SXT : KPP03845_104112(mshD_5) KPP03845_104882(mshD_6)
SGK : PET44_15315(mshD) PET44_21090
SYUN : MOV08_18335(mshD) MOV08_37300
SCOA : QU709_22690(mshD) QU709_43885
SCHG : NRO40_01125 NRO40_13825(mshD)
STTN : BSL84_15410 BSL84_21795
KSK : KSE_11000 KSE_43360(mshD)
KIT : CFP65_4290 CFP65_6354
AGLA : OIE69_19325(mshD) OIE69_38905
FSB : GCM10025867_14780(mshD)
PSEV : USB125703_00320(mshD_1)
LYH : FrondiHNR_04140(mshD)
AAGI : NCTC2676_1_02368(mshD)
PSNI : NIBR502771_10665(mshD)
MICK : B1A86_00008700(mshD)
RDN : HMPREF0733_10355(mshD)
BCV : Bcav_0268 Bcav_1396 Bcav_3429
BFA : Bfae_20190 Bfae_25650
BRX : BH708_09430 BH708_12935
BRV : CFK39_05370(mshD) CFK39_05890
BGG : CFK41_03580(mshD) CFK41_06555
BRZ : CFK38_05220 CFK38_05715(mshD)
LMOI : VV02_07155 VV02_19770
YIM : J5M86_04750 J5M86_12535(mshD) J5M86_13075
XYA : ET471_03460 ET471_07025(mshD)
CXIE : NP048_03860 NP048_14245(mshD)
ICA : Intca_2364 Intca_2950
JTE : ASJ30_01485 ASJ30_05235
JLI : EXU32_09530 EXU32_13890(mshD)
JME : EEW87_010245 EEW87_013605(mshD)
JAY : H7A72_01430(mshD) H7A72_05180
JCR : O9K63_10920 O9K63_13990(mshD)
PHW : G7075_03845 G7075_08495
PEI : H9L10_00060(mshD) H9L10_04415 H9L10_07855 H9L10_12350
SERJ : SGUI_1275 SGUI_2593
ORN : DV701_08570(mshD) DV701_15650
ORZ : FNH13_04145(mshD) FNH13_16230
OCP : NF557_02625(mshD) NF557_14055
PAUS : NCTC13651_02135(mshD)
PPC : HMPREF9154_0459(mshD)
MPH : MLP_40120 MLP_47690(mshD)
MIK : FOE78_04410 FOE78_22095(mshD)
MICG : GJV80_14280(mshD) GJV80_19290
TLA : TLA_TLA_02247(mshD_2)
RAIN : Rai3103_10105(mshD)
BROO : brsh051_08160(mshD)
NOO : FE634_18215(mshD) FE634_20670 FE634_21460
NSN : EXE58_05515 EXE58_08545 EXE58_10430(mshD) EXE58_15370
NANO : G5V58_19565(mshD) G5V58_20320 G5V58_22390 G5V58_22395
NMES : H9L09_04310 H9L09_06655(mshD) H9L09_11180
NPI : G7071_02935 G7071_06980(mshD)
NAQU : ENKNEFLB_00580(ypeA) ENKNEFLB_00734(mshD_1)
NRO : K8W59_15570(mshD) K8W59_16695
NOQ : LN652_10595(mshD) LN652_15730
NCQ : K6T13_01505 K6T13_15335(mshD)
NPC : KUV85_15585 KUV85_16585(mshD)
NPS : KRR39_17450 KRR39_22520(mshD)
NMAR : HPC71_01785 HPC71_18465(mshD)
PSIM : KR76_22915 KR76_26375
SGRG : L0C25_07525(mshD) L0C25_12510
NBT : KLP28_09025 KLP28_09375(mshD)
KFL : Kfla_0970 Kfla_1091 Kfla_2353 Kfla_3046 Kfla_3705
KQI : F1D05_02310 F1D05_24895(mshD) F1D05_29185 F1D05_35675 F1D05_37125
KSL : OG809_16420(mshD) OG809_17175 OG809_28290 OG809_28295
AGRA : AGRA3207_005165(mshD)
NOA : BKM31_24135 BKM31_41910
NCX : Nocox_03370(mshD2) Nocox_18705(mshD5)
NGN : LCN96_03365(mshD) LCN96_22550
NFS : OIE67_23990 OIE67_43490(mshD)
MHAI : OHB01_15210(mshD) OHB01_36525
AMQ : AMETH_3199(mshD) AMETH_6921(mshD)
PSEE : FRP1_20920 FRP1_24175
PSEH : XF36_18510 XF36_22780
PSEQ : AD006_00110 AD006_03365
PECQ : AD017_07935 AD017_11180
SESP : BN6_61750 BN6_81960(mshD)
SSYI : EKG83_27475 EKG83_45100(mshD)
KUT : JJ691_44230 JJ691_54730 JJ691_80890
KBU : Q4V64_02210 Q4V64_24120(mshD)
LED : BBK82_16220 BBK82_21610
ACTU : Actkin_06235(mshD_2)
CROS : N8J89_21260 N8J89_39975(mshD)
MAU : Micau_0490 Micau_0816 Micau_4761 Micau_5722 Micau_5748
MIL : ML5_0681 ML5_1059 ML5_2747 ML5_2774 ML5_3537
MICB : MicB006_0503 MicB006_0853 MicB006_1770 MicB006_1795 MicB006_3775
MTUA : CSH63_00725 CSH63_20415 CSH63_22800 CSH63_28595 CSH63_28725(mshD)
MICH : FJK98_04385 FJK98_29775(mshD)
MTEM : GCE86_23210(mshD) GCE86_28060 GCE86_29570
MCAB : HXZ27_04965 HXZ27_28585(mshD)
MSAG : GCM10017556_19730(mshD)
VMA : VAB18032_02160 VAB18032_02255
MCHL : PVK74_18745(mshD) PVK74_23540 PVK74_25335
MFEU : H1D33_04495(mshD) H1D33_09255 H1D33_10685
MPRN : Q3V37_02910 Q3V37_09355(mshD)
MHAW : RMN56_07580 RMN56_09130 RMN56_14190(mshD)
ASE : ACPL_4677 ACPL_7732 ACPL_7972
AMS : AMIS_74560 AMIS_76920
ACTN : L083_2127 L083_3896 L083_6523 L083_7756
AFS : AFR_10475 AFR_33890 AFR_39430 AFR_40750
ACTS : ACWT_4546 ACWT_7601 ACWT_7841
AIH : Aiant_35870 Aiant_38300(mshD)
ACTR : Asp14428_52340(mshD) Asp14428_54950
ACTL : L3i22_100660 L3i22_103030(mshD)
ASIC : Q0Z83_028700 Q0Z83_092760(mshD) Q0Z83_095360
AOU : ACTOB_008067 ACTOB_008307(mshD)
PLK : CIK06_00225 CIK06_24970 CIK06_26435(mshD)
PLAB : C6361_02920 C6361_11175(mshD) C6361_19185
PLAT : C6W10_08270(mshD) C6W10_18710 C6W10_28875
PFLA : Pflav_005230 Pflav_023570 Pflav_066180(mshD)
PSUU : Psuf_009460 Psuf_028140(mshD) Psuf_080040
ATL : Athai_00460(mshD) Athai_02340 Athai_46100
PRY : Prubr_17700 Prubr_31220(mshD) Prubr_33950 Prubr_54070
CATI : CS0771_09220(mshD) CS0771_18720 CS0771_43680 CS0771_51060 CS0771_72460
DVC : Dvina_03480(mshD) Dvina_04805 Dvina_24785 Dvina_30625
DMAT : Dmats_03160(mshD) Dmats_20395 Dmats_25705
CCAZ : COUCH_03240(mshD) COUCH_04545
TBW : NCTC13354_01322(mshD)
ABAM : B1s21122_05850(mshD)
EKE : EK0264_05800(mshD) EK0264_18935
LET : O77CONTIG1_04097(mshD)
PAGH : NIES204_04260(mshD)
OXY : HCG48_02510 HCG48_11200
OAC : Oscil6304_2182 Oscil6304_4104
ONI : Osc7112_0397 Osc7112_1131
RRS : RoseRS_1238 RoseRS_1431 RoseRS_2047
PBF : CFX0092_A1020 CFX0092_A1472 CFX0092_A3240 CFX0092_B0382 CFX0092_B0831
KBS : EPA93_00390 EPA93_01875 EPA93_07380 EPA93_08755 EPA93_41490 EPA93_42935
KBB : ccbrp13_02250 ccbrp13_39500 ccbrp13_45900 ccbrp13_47880
DMR : Deima_0739 Deima_0811
DGO : DGo_CA0224 DGo_PA0056
DSW : QR90_11360 QR90_14920
DCH : SY84_07755 SY84_11330
DAB : AUC44_01465 AUC44_02580
DEIN : DAAJ005_06830 DAAJ005_14520
PND : Pla175_20320(mshD_1)
GPN : Pan110_09750(mshD_1)
PBOR : BSF38_02534(mshD_2) BSF38_03408(mshD_4)
» show all
Taxonomy
Reference
Authors
Spies HS, Steenkamp DJ
Title
Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis.
Journal
Reference
Authors
Koledin T, Newton GL, Fahey RC
Title
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.
Journal
Sequence
Reference
Authors
Vetting MW, Roderick SL, Yu M, Blanchard JS
Title
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.189