KEGG   ENZYME: 2.3.1.190
Entry
EC 2.3.1.190                Enzyme                                 
Name
acetoin dehydrogenase system;
acetoin dehydrogenase complex;
acetoin dehydrogenase enzyme system;
AoDH ES;
acetoin dehydrogenase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:acetoin O-acetyltransferase
Reaction(IUBMB)
acetoin + CoA + NAD+ = acetaldehyde + acetyl-CoA + NADH + H+ [RN:R09524]
Reaction(KEGG)
R09524 > R13177
Substrate
acetoin [CPD:C00466];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
acetaldehyde [CPD:C00084];
acetyl-CoA [CPD:C00024];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires thiamine diphosphate. It belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, and EC 1.4.1.27, glycine cleavage system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
History
EC 2.3.1.190 created 2010, modified 2020
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:2061286]
  Authors
Priefert H, Hein S, Kruger N, Zeh K, Schmidt B, Steinbuchel A
  Title
Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism.
  Journal
J Bacteriol 173:4056-71 (1991)
DOI:10.1128/JB.173.13.4056-4071.1991
Reference
2  [PMID:8110297]
  Authors
Oppermann FB, Steinbuchel A
  Title
Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system.
  Journal
J Bacteriol 176:469-85 (1994)
DOI:10.1128/JB.176.2.469-485.1994
Reference
3  [PMID:8206840]
  Authors
Kruger N, Oppermann FB, Lorenzl H, Steinbuchel A
  Title
Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system.
  Journal
J Bacteriol 176:3614-30 (1994)
DOI:10.1128/JB.176.12.3614-3630.1994
Reference
4  [PMID:7813883]
  Authors
Huang M, Oppermann FB, Steinbuchel A
  Title
Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.
  Journal
FEMS Microbiol Lett 124:141-50 (1994)
DOI:10.1111/j.1574-6968.1994.tb07276.x
Reference
5  [PMID:10368162]
  Authors
Huang M, Oppermann-Sanio FB, Steinbuchel A
  Title
Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway.
  Journal
J Bacteriol 181:3837-41 (1999)
DOI:10.1128/JB.181.12.3837-3841.1999
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.190
IUBMB Enzyme Nomenclature: 2.3.1.190
ExPASy - ENZYME nomenclature database: 2.3.1.190
BRENDA, the Enzyme Database: 2.3.1.190

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