KEGG ENZYME: 2.3.1.192

ENZYME: 2.3.1.192

Entry

EC 2.3.1.192                Enzyme

Name

glycine N-phenylacetyltransferase;
arylacetyl-CoA N-acyltransferase;
arylacetyltransferase;
GAT (gene name)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

phenylacetyl-CoA:glycine N-phenylacetyltransferase

Reaction(IUBMB)

phenylacetyl-CoA + glycine = CoA + phenylacetylglycine [RN:R05841]

Reaction(KEGG)

R05841

Substrate

phenylacetyl-CoA [CPD:C00582];
glycine [CPD:C00037]

Product

CoA [CPD:C00010];
phenylacetylglycine [CPD:C05598]

Comment

Not identical with EC 2.3.1.13 (glycine N-acyltransferase).
This enzyme was purified from bovine liver mitochondria. L-asparagine, L-glutamine and L-arginine are alternative substrates to glycine, but have higher Km values.

History

EC 2.3.1.192 created 2010

Pathway

ec00360

Phenylalanine metabolism

Orthology

K15517

glycine N-phenylacetyltransferase

Genes

CSYR:

103269913

MMUR:

105863142

LCAT:

123642732

PCOQ:

105809997

OGA:

100958872

MMU:	240549(Gm4952)

MCAL:

110285808

MPAH:

110334998

RNO:	309227(Glyatl1)

MCOC:

116101065

ANU:

117695227

MUN:

110565451

CGE:

100767729

MAUA:

101831264

PROB:

127228905

PLEU:

114703388

MORG:

121454180

MFOT:

126498311

AAMP:

119803376

NGI:

103733339

HGL:

101711041

CPOC:

100723240 100723515 100723793 100725009

CCAN:

109678085

DORD:

105995256

DSP:

122105365

PLOP:

125362691

NCAR:

124958706 124958708

MMMA:

107135858 107135859

OCU:

100353150

OPI:

101520259

TUP:

102491601

GVR:

103597523

CFA:

483462

CLUD:

112663395

VVP:

112930486

VLG:

121472025

NPO:

129494136

UMR:

103666138

UAH:

113246550

UAR:

123785073

ELK:

111149994

LLV:

125078916

MPUF:

101672241

MNP:

132020859

MLK:

131812982

NVS:

122912952

ORO:

101370540

EJU:

114215402

ZCA:

113915067

MLX:

118016301

NSU:

110575842

LWW:

102738630

FCA:

101098257

PYU:

121043387

PCOO:

112865397

PBG:

122483803

PVIV:

125176692

LRUF:

124506452

PTG:

102966488

PPAD:

109246473

PUC:

125933294

AJU:

113592388

HHV:

120240386

BTA:	112441481 280801(GAT)

BOM:

102284675

BIU:

109569853

BBUB:

123329683 123464552

BBIS:

104988614 105001007

CHX:

102175783

OAS:

101108949

BTAX:

128060788

ODA:

120877112

CCAD:

122449390 122449921

MBEZ:

129554873 129554875

SSC:

100517803

CFR:

102512072

CBAI:

105070058

CDK:

105094919

VPC:

102544185

BACU:

103014180

BMUS:

118900008

LVE:

103084684

OOR:

101287278

DLE:

111183923

PCAD:

102988322

PSIU:

116758228

NASI:

112402158

ECB:

100068389

EPZ:

103556887

EAI:

106825140

MYB:

102251191

MYD:

102768664

MMYO:

118664989

MLF:

102438929

PKL:

118712811

EFUS:

103292670

DRO:

112303569

SHON:

118996869(GLYAT)

AJM:	119058880(GLYAT)

PDIC:

114500945

PHAS:

123829309

MMF:	118628379 118628415

PPAM:

129062726

MJV:

108407616

TOD:

119255257

SARA:

101552414

ETF:

101646478

DNM:	101422296 101423464

GAS:

123252717

MUO:

115482225

PMEO:

129588606

PMAX:

117339082

» show all

Reference

1 [PMID:457678]

Authors

Nandi DL, Lucas SV, Webster LT Jr

Title

Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization.

Journal

J Biol Chem 254:7230-7 (1979)

Reference

2 [PMID:2283662]

Authors

Kelley M, Vessey DA

Title

The effects of ions on the conjugation of xenobiotics by the aralkyl-CoA and arylacetyl-CoA N-acyltransferases from bovine liver mitochondria.

Journal

J Biochem Toxicol 5:125-35 (1990)
DOI:10.1002/jbt.2570050208

Reference

3 [PMID:9664233]

Authors

Vessey DA, Lau E

Title

Determination of the sequence of the arylacetyl acyl-CoA:amino acid N-acyltransferase from bovine liver mitochondria and its homology to the aralkyl acyl-CoA:amino acid N-acyltransferase.

Journal

J Biochem Mol Toxicol 12:275-9 (1998)
DOI:10.1002/(SICI)1099-0461(1998)12:5<275::AID-JBT3>3.0.CO;2-I

Sequence

[bta:280801]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.192

IUBMB Enzyme Nomenclature:

2.3.1.192

ExPASy - ENZYME nomenclature database:

2.3.1.192

BRENDA, the Enzyme Database:

2.3.1.192

DBGET integrated database retrieval system