KEGG   ENZYME: 2.3.1.194
Entry
EC 2.3.1.194                Enzyme                                 
Name
acetoacetyl-CoA synthase;
NphT7
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating)
Reaction(IUBMB)
acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2 [RN:R09527]
Reaction(KEGG)
R09527
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083]
Product
acetoacetyl-CoA [CPD:C00332];
CoA [CPD:C00010];
CO2 [CPD:C00011]
Comment
The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway.
Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.
History
EC 2.3.1.194 created 2011
Orthology
K21378  acetoacetyl-CoA synthase
Genes
PJUL1P09_23580
AGZM0C34_04365
DOEDENOEST_2906
MULMUL_3531(fabH_1)
MMIMMAR_3221(fabH_1)
MMAEMMARE11_31210(fabH_1)
MLIMULP_03448(fabH_1)
MPSEMPSD_33000(fabH-1)
MSHOMSHO_46320(fabH-1)
CFGCFREI_08305(nphT7)
NBRO3I_033200
NIEKV110_32250
SGRFSGFS_040890
SVLStrvi_3790
SBHSBI_01378
SDVBN159_7956(fabH5)
SALSSLNWT_0281
SGUSGLAU_17330(nphT7)
STRMM444_04515
SPAVSpa2297_32700
SGMGCM10017557_24430(fabH-1)
SCADDN051_13605
SPHWNFX46_18825
SLSSLINC_8377
SSIAA7J05_00465
SPUNBFF78_11395
SFKKY5_7817c
SQZFQU76_00370 FQU76_33370
SKACP970_00360
SVNCP980_14890
SSPBCP982_28325
SNFJYK04_00151(nphT7)
STUIGCM10017668_35440(fabH)
SHUNDWB77_00552(nphT7)
SCYGS1361_04940(nphT7)
SDWK7C20_10900
SROIIAG44_00125
SNIGHEK616_55620(fabH-1)
SSPNLXH13_23555
SXTKPP03845_300055(nphT7)
SENGOJ254_01965
SGKPET44_03085
SANTQR300_05535
SARGHKX69_17150
SFIYF0344_11635
SINNABB07_06635 ABB07_39205
SCTSCAT_p1096
SCYSCATT_p06400
KSKKSE_59090(fabH4)
STRIC7M71_014720
STRHGXP74_01205
AUSIPK37_18440
NDANdas_3368
NAKEKGD83_08240
SNAHOUQ99_07025
AGRAAGRA3207_007749
NFSOIE67_22435
FRAFrancci3_0990
SACCEYD13_07800(nphT7)
AMYCCU254_12895
AMYYYIM_32850(nphT2)
SSYIEKG83_10425(fabH) EKG83_15870
KUTJJ691_101580 JJ691_31650(fabH_2)
KBUQ4V64_43015
AHMTL08_19815
ACTIUA75_17080 UA75_23345
ACADUA74_16550 UA74_22835
AHGAHOG_20700(nphT7)
PMADBAY61_22975
MICBMicB006_2931
MICHFJK98_16190
MCHLPVK74_09610
ACTNL083_4421
AFSAFR_19640
AIHAiant_54280(fabH_1)
ACTRAsp14428_01880(fabH-1)
ASICQ0Z83_077830 Q0Z83_079870
AOUACTOB_001048
PFLAPflav_056930
PSUUPsuf_000190(fabH-1) Psuf_016510(fabH-2)
PRYPrubr_58570(fabH_2)
DVCDvina_05840
DFUDfulv_24035
DMATDmats_05320
CCAZCOUCH_23990
 » show all
Reference
1  [PMID:20534558]
  Authors
Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T
  Title
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
  Journal
Proc Natl Acad Sci U S A 107:11265-70 (2010)
DOI:10.1073/pnas.1000532107
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.194
IUBMB Enzyme Nomenclature: 2.3.1.194
ExPASy - ENZYME nomenclature database: 2.3.1.194
BRENDA, the Enzyme Database: 2.3.1.194

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