KEGG   ENZYME: 2.3.1.220
Entry
EC 2.3.1.220                Enzyme                                 
Name
2,4,6-trihydroxybenzophenone synthase;
benzophenone synthase (ambiguous);
BPS (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:benzoyl-CoA malonyltransferase (2,4,6-trihydroxybenzophenone-forming)
Reaction(IUBMB)
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 [RN:R02447]
Reaction(KEGG)
R02447
Substrate
malonyl-CoA [CPD:C00083];
benzoyl-CoA [CPD:C00512]
Product
CoA [CPD:C00010];
2,4,6-trihydroxybenzophenone [CPD:C06356];
CO2 [CPD:C00011]
Comment
Involved in the biosynthesis of plant xanthones. The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151, 2,3',4,6-tetrahydroxybenzophenone synthase).
History
EC 2.3.1.220 created 2013
Orthology
K21386  2,4,6-trihydroxybenzophenone synthase
Reference
1  [PMID:9459298]
  Authors
Schmidt W, Beerhues L
  Title
Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L.
  Journal
FEBS Lett 420:143-6 (1997)
DOI:10.1016/S0014-5793(97)01507-X
  Sequence
[ag:AAL79808]
Reference
2  [PMID:22390826]
  Authors
Nualkaew N, Morita H, Shimokawa Y, Kinjo K, Kushiro T, De-Eknamkul W, Ebizuka Y, Abe I
  Title
Benzophenone synthase from Garcinia mangostana L. pericarps.
  Journal
Phytochemistry 77:60-9 (2012)
DOI:10.1016/j.phytochem.2012.02.002
  Sequence
[ag:AEI27291]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.220
IUBMB Enzyme Nomenclature: 2.3.1.220
ExPASy - ENZYME nomenclature database: 2.3.1.220
BRENDA, the Enzyme Database: 2.3.1.220

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (2)   
   PDBSTR (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   InterPro (4)   
All databases (21)   

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