KEGG ENZYME: 2.3.1.227

ENZYME: 2.3.1.227

Entry

EC 2.3.1.227                Enzyme

Name

GDP-perosamine N-acetyltransferase;
perB (gene name);
GDP-alpha-D-perosamine N-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:GDP-4-amino-4,6-dideoxy-alpha-D-mannose N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose [RN:R10514]

Reaction(KEGG)

R10514

Substrate

acetyl-CoA [CPD:C00024];
GDP-4-amino-4,6-dideoxy-alpha-D-mannose [CPD:C20638]

Product

CoA [CPD:C00010];
GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose [CPD:C20672]

Comment

D-Perosamine is one of several dideoxy sugars found in the O-antigen component of the outer membrane lipopolysaccharides of Gram-negative bacteria.

History

EC 2.3.1.227 created 2013

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec00541

O-Antigen nucleotide sugar biosynthesis

ec01100

Metabolic pathways

Orthology

K17939

GDP-perosamine N-acetyltransferase

Genes

ECE:	Z3192(wbdR)

ECS:	ECs_2831(neuD)

ETW:	ECSP_2781(wbdR)

ELX:	CDCO157_2613

Reference

1 [PMID:18201574]

Authors

Albermann C, Beuttler H

Title

Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.

Journal

FEBS Lett 582:479-84 (2008)
DOI:10.1016/j.febslet.2008.01.005

Sequence

[ece:Z3192] [ecs:ECs_2831]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.227

IUBMB Enzyme Nomenclature:

2.3.1.227

ExPASy - ENZYME nomenclature database:

2.3.1.227

BRENDA, the Enzyme Database:

2.3.1.227

DBGET integrated database retrieval system