KEGG ENZYME: 2.3.1.228

ENZYME: 2.3.1.228

Entry

EC 2.3.1.228                Enzyme

Name

isovaleryl-homoserine lactone synthase;
IV-HSL synthase;
BjaI

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

isovaleryl-CoA:S-adenosyl-L-methionine isovaleryltranserase (lactone-forming, methylthioadenosine-releasing)

Reaction(IUBMB)

isovaleryl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone [RN:R10526]

Reaction(KEGG)

R10526

Substrate

isovaleryl-CoA [CPD:C02939];
S-adenosyl-L-methionine [CPD:C00019]

Product

CoA [CPD:C00010];
S-methyl-5'-thioadenosine [CPD:C00170];
N-isovaleryl-L-homoserine lactone [CPD:C20673]

Comment

The enzyme, found in the bacterium Bradyrhizobium japonicum, does not accept isovaleryl-[acyl-carrier protein] as acyl donor (cf. EC 2.3.1.184, acyl-homoserine-lactone synthase).

History

EC 2.3.1.228 created 2013

Orthology

K18096

acyl-homoserine lactone synthase

Genes

MLO:	mlr5638 mlr9546

MLN:	A9174_33415

MCI:	Mesci_2559 Mesci_5994

MCIC:

A4R28_28615 A4R28_32030

MOP:	Mesop_2739 Mesop_2831 Mesop_6641

MAM:	Mesau_02680 Mesau_06035

MAMO:

A6B35_07925

MESW:

A9K65_013700 A9K65_032155

MESM:

EJ066_11350 EJ066_20355

MHUA:

MCHK_0049

MJR:	EB229_34195 EB229_34600

MERD:

EB233_31980

MESR:

FGU64_08000

MOH:	IHQ72_35230

MMEI:

LRP31_32305

MESO:

BSQ44_20295

MES:

Meso_2312

HOE:	IMCC20628_01503

AAK:	AA2016_6360

AMIH:

CO731_00370(bjaI_1)

AMIS:

Amn_pb02150

NIY:	FQ775_07800

AGC:	BSY240_834

AVI:

Avi_9666

RLE:	pRL100164(rhiI)

RLU:	RLEG12_00720

RHL:	LPU83_pLPU83c0631

RJG:	CCGE525_36400

RII:	FFM53_032970

RHID:

FFM81_031975

RLN:	J0663_30455

RRG:	J3P73_35610

RLS:	HB780_09580

RROS:

D4A92_16435

RLW:	RlegWSM1455_27280

RRHO:

PR018_26770

RTU:	PR017_18045

NEN:	NCHU2750_12520

NPM:	QEO92_06490

BJA:	blr1063(blr1063)

BJU:	BJ6T_10890

BJP:	RN69_05315

BRA:

BRADO0941

BBT:

BBta_7113

BRS:

S23_67510

AOL:	S58_60330 S58_66860

BRC:	BCCGELA001_34325

BRO:	BRAD285_0435

BRK:	CWS35_37480

BOT:	CIT37_08970

BRQ:	CIT40_30110

BGQ:	X265_34710

BGZ:	XH91_33100

BSYM:

CIT39_29245

BBET:

F8237_13100 F8237_34755

BARH:

WN72_46260

BVZ:	BRAD3257_8661(bjaI)

BDG:	LPJ38_02210

BSEI:

KMZ68_23880

BBAN:

J4G43_003685

BCAN:

BcanWSM471_35510

BAUT:

QA635_33965

BCOU:

IC761_34700

BXN:	I3J27_37650

BRAZ:

LRP30_42210

RPA:	TX73_001660(rpaI)

RPB:	RPB_0417 RPB_3320

RPC:

RPC_0701

RPD:	RPD_0403 RPD_2175

RPE:

RPE_2323

RPT:	Rpal_0322 Rpal_2331

RPX:	Rpdx1_0306 Rpdx1_2086

RBK:	E0H22_12665

NWI:

Nwi_0626

NHA:	Nham_0959 Nham_4466

OCA:

OCAR_7682

OCG:	OCA5_pHCG300170(solI) OCA5_pOC16701320

OCO:	OCA4_pHCG3B00170(solI) OCA4_pOC167B01320

VGO:	GJW-30_1_04004(bjaI)

TRB:	HB776_06360

TALZ:

RPMA_16385

BVV:	BHK69_08180 BHK69_31115

BOI:	BLM15_21180 BLM15_29660 BLM15_30405

BVES:

QO058_16175

APOL:

K9D25_24260

MEA:	Mex_1p4961(mlaI) Mex_2p0693(msaI)

MDI:

METDI5550

MEX:

Mext_4513

MCH:

Mchl_4976

MPO:

Mpop_5028

MZA:	B2G69_04550

MRD:	Mrad2831_4020 Mrad2831_5763 Mrad2831_6377 Mrad2831_6407

MET:

M446_5461

MNO:	Mnod_0283 Mnod_1765

MOR:	MOC_6267(solI)

META:

Y590_23010

MAQU:

Maq22A_1p31045(lasI) Maq22A_c03535(lasI)

MPHY:

MCBMB27_04977

MEE:	DA075_07640 DA075_25820

METD:

C0214_24845

METX:

A3862_02270

METS:

DK389_13805

METI:

DK427_22570

MMES:

MMSR116_10765

MTEA:

DK419_10610 DK419_27810

MIND:

mvi_38440(bjaI) mvi_41110 mvi_63760

MIV:	C4E04_04460

MICO:

GDR74_14865

MTEZ:

HPT29_005830 HPT29_020790

MLD:	U0023_03365

MEDK:

QEV83_18710

BBAR:

RHAL1_P00105

CHEL:

AL346_15205 AL346_16885

MCG:

GL4_0847

DEI:	C4375_05150

DEA:	FPZ08_21260

DSAL:

K1X15_01365

BVR:

BVIR_1467

BLAG:

BLTE_10030

JAV:	OXU80_18350

PSIN:

CAK95_24600

PHR:	C6569_18320

PAQT:

E8L99_01335

CMB:	CSW64_05505 CSW64_17930

CFH:	C1707_25605

CAUF:

CSW63_05715

CAUL:

KCG34_09810

PZU:

PHZ_p0006

PSAP:

JHX88_21865

PAEZ:

PAE61_04890

TMO:	TMO_c0698(rhlI)

ECOG:

FIV45_06260

» show all

Reference

1 [PMID:21949379]

Authors

Lindemann A, Pessi G, Schaefer AL, Mattmann ME, Christensen QH, Kessler A, Hennecke H, Blackwell HE, Greenberg EP, Harwood CS

Title

Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum.

Journal

Proc Natl Acad Sci U S A 108:16765-70 (2011)
DOI:10.1073/pnas.1114125108

Sequence

[bja:blr1063]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.228

IUBMB Enzyme Nomenclature:

2.3.1.228

ExPASy - ENZYME nomenclature database:

2.3.1.228

BRENDA, the Enzyme Database:

2.3.1.228

DBGET integrated database retrieval system