Entry |
|
Name |
5-methylnaphthoic acid synthase;
AziB
|
Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
|
Sysname |
malonyl-CoA:acetyl-CoA malonyltransferase (5-methyl-1-naphthoic acid-forming)
|
Reaction(IUBMB) |
acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ = 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ [RN: R11124]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
A multi-domain polyketide synthase involved in the synthesis of azinomycin B in the bacterium Streptomyces griseofuscus.
|
History |
EC 2.3.1.236 created 2014
|
Orthology |
K21381 | 5-methylnaphthoic acid synthase |
|
Reference |
|
Authors |
Zhao Q, He Q, Ding W, Tang M, Kang Q, Yu Y, Deng W, Zhang Q, Fang J, Tang G, Liu W |
Title |
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.236 |
|