KEGG   ENZYME: 2.3.1.237
Entry
EC 2.3.1.237                Enzyme                                 
Name
neocarzinostatin naphthoate synthase;
naphthoic acid synthase;
NNS;
ncsB (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid-forming)
Reaction(IUBMB)
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+ [RN:R11125]
Reaction(KEGG)
R11125
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
2-hydroxy-5-methyl-1-naphthoate [CPD:C20856];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Comment
A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
History
EC 2.3.1.237 created 2014
Pathway
ec01059  Biosynthesis of enediyne antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20422  neocarzinostatin naphthoate synthase
Genes
PSEP: C4K39_3072
SGZ: C0216_12005
SEN: SACE_5532
AORI: SD37_05100
AROO: NQK81_30350
SAQ: Sare_4951
MICH: FJK98_15495
ACTN: L083_3191(pks3C)
Reference
1  [PMID:15147895]
  Authors
Sthapit B, Oh TJ, Lamichhane R, Liou K, Lee HC, Kim CG, Sohng JK
  Title
Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.
  Journal
FEBS Lett 566:201-6 (2004)
DOI:10.1016/j.febslet.2004.04.033
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.237
IUBMB Enzyme Nomenclature: 2.3.1.237
ExPASy - ENZYME nomenclature database: 2.3.1.237
BRENDA, the Enzyme Database: 2.3.1.237

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (9)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (21)   
   InterPro (21)   
All databases (51)   

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