Entry |
|
Name |
neocarzinostatin naphthoate synthase;
naphthoic acid synthase;
NNS;
ncsB (gene name)
|
Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
|
Sysname |
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid-forming)
|
Reaction(IUBMB) |
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+ [RN: R11125]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
|
History |
EC 2.3.1.237 created 2014
|
Pathway |
ec01059 | Biosynthesis of enediyne antibiotics |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K20422 | neocarzinostatin naphthoate synthase |
|
Genes |
|
Reference |
|
Authors |
Sthapit B, Oh TJ, Lamichhane R, Liou K, Lee HC, Kim CG, Sohng JK |
Title |
Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.237 |
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