| Entry |
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| Name |
monacolin J acid methylbutanoate transferase;
LovD
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
monacolin J acid:(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] (S)-2-methylbutanoate transferase
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| Reaction(IUBMB) |
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = lovastatin acid + [2-methylbutanoate polyketide synthase]
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| Reaction(KEGG) |
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| Substrate |
monacolin J acid [CPD: C20854];
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
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| Product |
lovastatin acid [CPD: C21130];
[2-methylbutanoate polyketide synthase]
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| Comment |
The enzyme catalyses the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus.
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| History |
EC 2.3.1.238 created 2014
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| Pathway |
| ec00997 | Biosynthesis of various other secondary metabolites |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K20983 | monacolin J acid methylbutanoate transferase |
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| Reference |
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| Authors |
Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR |
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| Title |
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y |
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| Title |
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y |
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| Title |
Acyltransferase mediated polyketide release from a fungal megasynthase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.238 |
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