Entry
Name
phosphatidylinositol dimannoside acyltransferase;
PIM2 acyltransferase;
ptfP1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol acyltransferase
Reaction(IUBMB)
(1) an acyl-CoA + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [RN:
R11781 R12042 ];
(2) an acyl-CoA + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [RN:
R11782 R12039 ]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:
C00040 ];
2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:
C21607 ];
2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:
C21606 ]
Product
CoA [CPD:
C00010 ];
2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:
C21608 ];
2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [CPD:
C21609 ]
Comment
The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs).
History
EC 2.3.1.265 created 2017
Pathway
ec00571 Lipoarabinomannan (LAM) biosynthesis
Orthology
K22311 phosphatidylinositol dimannoside acyltransferase
Genes
TTU : TERTU_4520 TERTU_4526
DCB : C3Y92_18880 C3Y92_19850
DSD : GD606_11475 GD606_11495
CCRO : CMC5_039830 CMC5_042060
LLU : AKJ09_08885 AKJ09_09086
MPAG : C0J29_12020 C0J29_13840
MGOR : H0P51_00755 H0P51_11470
MKY : IWGMT90018_01600 IWGMT90018_36870
MIJ : MINS_23150 MINS_25620
MBRM : L2Z93_002007 L2Z93_002266
NFR : ERS450000_00343 ERS450000_03973 ERS450000_06186
NCY : NOCYR_3607 NOCYR_4596
NOD : FOH10_18030 FOH10_20085
NGP : LTT66_20800 LTT66_25000
NSPU : IFM12276_11480 IFM12276_18620
RPY : Y013_02055 Y013_03725
RBY : CEJ39_12750 CEJ39_14375
RHQ : IM25_16040 IM25_17580
RRT : 4535765_02114 4535765_02554
RGOR : NMQ04_09365 NMQ04_10760
SLE : sle_55850(sle_55850)
AIH : Aiant_22450 Aiant_81580
ACTL : L3i22_041910 L3i22_088240
ASIC : Q0Z83_024050 Q0Z83_107010
CCAZ : COUCH_13040 COUCH_25685
DFO : Dform_00687(lpxL|htrB) Dform_01755(lpxL|htrB)
TBH : Tbon_02375 Tbon_02380
SACI : Sinac_2244 Sinac_2828 Sinac_7430
PBOR : BSF38_01250(lpxL_2)
» show all
Taxonomy
Reference
Authors
Svetlikova Z, Barath P, Jackson M, Kordulakova J, Mikusova K
Title
Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.265