KEGG ENZYME: 2.3.1.273

ENZYME: 2.3.1.273

Entry

EC 2.3.1.273                Enzyme

Name

diglucosylglycerate octanoyltransferase;
octT (gene name);
DGG octanoyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

octanoyl-CoA:2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate octanoyltransferase

Reaction(IUBMB)

octanoyl-CoA + 2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate = CoA + 2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate [RN:R12159]

Reaction(KEGG)

R12159

Substrate

octanoyl-CoA [CPD:C01944];
2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate [CPD:C21968]

Product

CoA [CPD:C00010];
2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-D-glycerate [CPD:C21969]

Comment

The enzyme, characterized from mycobacteria, is involved in the biosynthesis of methylglucose lipopolysaccharide (MGLP). The enzyme can also act on 2-O-(alpha-D-glucopyranosyl)-D-glycerate, but with lower activity.

History

EC 2.3.1.273 created 2018

Orthology

K22797

diglucosylglycerate octanoyltransferase

Genes

MICZ:

GL2_16410

PSTG:

E8M01_06795

AOT:	AcetOri_orf03649

DDS:

Ddes_1578

DEF:	CNY67_05065

MFB:	MFUL124B02_10855

EUZ:	DVS28_a2824

MTU:

Rv2418c

MTV:	RVBD_2418c

MTC:

MT2491

MRA:

MRA_2444

MTF:	TBFG_12446

MTB:	TBMG_01556

MTK:	TBSG_01566

MTZ:	TBXG_001542

MTG:	MRGA327_14920

MTI:	MRGA423_15075

MTE:	CCDC5079_2236

MTUR:

CFBS_2562

MTL:	CCDC5180_2206

MTO:	MTCTRI2_2462

MTD:

UDA_2418c

MTN:	ERDMAN_2661

MTJ:	J112_12975

MTUB:

MT7199_2450

MTUC:

J113_16815

MTUE:

J114_12955

MTX:	M943_12495

MTUH:

I917_17070

MTUL:

TBHG_02357

MTUT:

HKBT1_2553

MTUU:

HKBT2_2556

MTQ:	HKBS1_2560

MBO:	BQ2027_MB2441C

MBB:

BCG_2434c

MBT:

JTY_2428

MBM:	BCGMEX_2424c

MBK:	K60_025090

MBX:

BCGT_2248

MAF:

MAF_24330

MMIC:

RN08_2681

MCE:	MCAN_24521

MCQ:	BN44_50391

MCV:	BN43_40072

MCX:	BN42_40363

MCZ:	BN45_50794

MORY:

MO_002536(octT)

MPA:

MAP_2241c

MAO:

MAP4_1583

MAVI:

RC58_07885

MAVU:

RE97_07885

MAV:

MAV_1753

MIT:

OCO_18100

MIA:

OCU_18280

MID:

MIP_02553

MYO:

OEM_16110

MCHI:

AN480_08900

MIR:

OCQ_15710

MMAL:

CKJ54_07775

MLP:

MLM_2759

MMAN:

MMAN_23510

MSA:	Mycsm_04189

MUL:

MUL_3690

MMI:

MMAR_3746

MMAE:

MMARE11_36530

MLI:	MULP_03998

MPSE:

MPSD_38150

MSHO:

MSHO_31920(octT)

MMC:

Mmcs_3527

MKM:

Mkms_3600

MJL:

Mjls_3532

MMM:

W7S_07705

MKN:	MKAN_05155

MYV:	G155_19510

MYE:	AB431_20155

MHAD:

B586_09015

MDX:	BTO20_12035

MSHG:

MSG_03419(octT)

MFJ:	MFLOJ_52820

MSTO:

MSTO_56910(octT)

MSIM:

MSIM_42080

MSAK:

MSAS_16280

MKU:	I2456_18080

MLW:	MJO58_18870

MXE:	MYXE_18380

MNV:	MNVI_01290

MPAG:

C0J29_20890

MNM:	MNVM_04020(octT)

MGOR:

H0P51_18945

MCOO:

MCOO_14830(octT)

MBAI:

MB901379_03328

MSEO:

MSEO_22300

MHEK:

JMUB5695_01943(octT)

MGAU:

MGALJ_23100(octT)

MLJ:	MLAC_25050

MBRD:

MBRA_33870(octT)

MSHJ:

MSHI_07880

MMAM:

K3U93_16045

MSPG:

F6B93_15220

MOT:	LTS72_05995

MLM:	MLPF_2093(octT)

MPAA:

MKK62_08550

MMEH:

M5I08_11310

MKY:	IWGMT90018_20580(octT)

MADI:

A7U43_12400

MWU:	PT015_08470

MSM:	MSMEG_4578

MSG:	MSMEI_4466

MSB:	LJ00_22655

MSN:	LI99_22660

MSH:	LI98_22665

MVA:

Mvan_3923

MGI:

Mflv_2656

MSP:	Mspyr1_20910

MCB:	Mycch_3411

MNE:	D174_19070

MYN:	MyAD_18705

MFT:	XA26_39810

MPHL:

MPHLCCUG_03564

MVQ:

MYVA_3754

MLL:	B1R94_09730

MRH:	MycrhN_4233

MTHN:

4412656_02842

MHAS:

MHAS_01279(octT)

MDU:	MDUV_06690(octT)

MCHT:

MCHIJ_31240(octT)

MDR:	MDOR_25970(octT)

MAUU:

NCTC10437_03700

MMAG:

MMAD_36900(octT)

MMOR:

MMOR_26570(octT)

MFX:	MFAL_14730(octT)

MAIC:

MAIC_35750

MIJ:	MINS_33470(octT)

MALV:

MALV_00410(octT)

MTY:	MTOK_59620(octT)

MPSC:

MPSYJ_28590(octT)

MARZ:

MARA_59970(octT)

MGAD:

MGAD_00870(octT)

MHEV:

MHEL_01770

MSAR:

MSAR_46240

MANY:

MANY_20280(octT)

MAUB:

MAUB_49290(octT)

MPOF:

MPOR_40810(octT)

MPHU:

MPHO_20280(octT)

MMUC:

C1S78_008230

MMAT:

MMAGJ_76490(octT)

MBOK:

MBOE_34050(octT)

MFG:	K6L26_12185

MSEI:

MSEDJ_48650(octT)

MFLV:

NCTC10271_01724

MCEE:

MCEL_02040

MBRM:

L2Z93_002455

MMON:

EWR22_18205

MGO:	AFA91_17535

MHOL:

K3U96_09485

MSEN:

K3U95_10405

MPAE:

K0O64_19440

MRF:	MJO55_17845

MDF:	K0O62_19295

MCRO:

MI149_20285

MGRO:

FZ046_23355

MKR:	MKOR_03450(octT)

MPAK:

MIU77_06000

MAB:

MAB_1624

MMV:	MYCMA_10500

MABB:

MASS_1718

MABL:

MMASJCM_1646

MCHE:

BB28_08845

MIZ:	BAB75_08800

MSTE:

MSTE_01624

MSAO:

MYCSP_07360

MSAL:

DSM43276_01486

MJD:	JDM601_1490

MTER:

4434518_01386

MMIN:

MMIN_30860(octT)

MHIB:

MHIB_09440(octT)

MHER:

K3U94_08155

MVM:	MJO54_08170

ASD:

AS9A_1141

NFA:

NFA_13790

NFR:	ERS450000_02728

NCY:	NOCYR_1449

NBR:	O3I_009285

NNO:	NONO_c58630

NSL:	BOX37_06825

NSR:	NS506_06755

NTP:	CRH09_10520

NOZ:	DMB37_30070

NOD:	FOH10_22475

NAH:	F5544_11835

NAD:	NCTC11293_02365

NWL:	NWFMUON74_53790

NIE:	KV110_09825

NTC:	KHQ06_35010

NHU:	H0264_34105

NYA:	LTV02_38825

NGP:	LTT66_04280

NSPU:

IFM12276_48250

NYU:	D7D52_09385

RHA:	RHA1_ro01294

RER:

RER_37730

REY:

O5Y_17410

REB:	XU06_17620

RQI:	C1M55_18600

ROP:

ROP_10160

ROA:	Pd630_LPD05398

RPY:	Y013_06590

RBY:	CEJ39_17505

RHB:

NY08_440

RAV:	AAT18_16220

RFA:	A3L23_03763

RHS:	A3Q41_04477

RHW:	BFN03_10525

RRZ:	CS378_05810

RHU:	A3Q40_01034

RHQ:	IM25_20605

RHOD:

AOT96_29230

RRT:	4535765_03136

RCR:	NCTC10994_04110

RTM:	G4H71_01765

RKO:	JWS14_06695

RGO:	KYT97_25960

ROZ:	CBI38_11380

RPSK:

JWS13_39755

RGOR:

NMQ04_13450

RANT:

RHODO2019_11315

RHOP:

D8W71_19800

REQ:

REQ_29640

PDEF:

P9209_14300

WHR:	OG579_05300

GBR:

Gbro_3191

GPO:	GPOL_c29670

GOR:

KTR9_3225

GOQ:	ACH46_13920

GTA:	BCM27_16425

GOC:	CXX93_09080

GIT:	C6V83_14005

GRU:	GCWB2_16600

GOM:	D7316_00081(octT)

GAV:	C5O27_11555

GOD:	GKZ92_15525

GAM:	GII34_15295

GPD:	GII33_14485

GJI:	H1R19_15470

GOI:	LK459_18450

GHN:	MVF96_15895

GAMI:

IHQ52_19400

GMG:	NWF22_00960

GSI:	P5P27_13170

SPIN:

KV203_06015

TPR:

Tpau_2805

TSM:	ASU32_15710

TPUL:

TPB0596_16620(octT)

TSD:	MTP03_32450(octT)

SRT:

Srot_1009

CBQ:	AL705_07190

TOY:	FO059_12800

SVI:	Svir_12570

SACC:

EYD13_06870

AMD:

AMED_6692

AMN:

RAM_34330

AMM:

AMES_6593

AMZ:

B737_6593

AOI:

AORI_2015

AJA:	AJAP_29455

AMQ:	AMETH_1786

AMYC:

CU254_26780

AMYB:

BKN51_02230

AAB:	A4R43_39335

AMYY:

YIM_38520

AORI:

SD37_31095

AACD:

LWP59_09225

APRT:

MUY14_03490

AROO:

NQK81_12450

ATHM:

L1857_11610

ARHD:

VSH64_22840(octT)

PDX:

Psed_2007

PSEA:

WY02_25470

PSEE:

FRP1_05970

PSEQ:

AD006_13595

PECQ:

AD017_21430

PHH:	AFB00_02830

PAUT:

Pdca_47010

PBRO:

HOP40_16420

PPEL:

H6H00_16005

APRE:

CNX65_05990

AMI:

Amir_1200

SESP:

BN6_14360

SSYI:

EKG83_07005

KAL:

KALB_1628

KUT:	JJ691_57970(octT)

KPHY:

AOZ06_11750

LED:	BBK82_04350

AHM:	TL08_08240

ACTI:

UA75_08245

ACAD:

UA74_08265

AHG:	AHOG_07750

ALO:

CRK55494

PMAD:

BAY61_08905

ACTU:

Actkin_01393

CROS:

N8J89_07230

ACTY:

OG774_00470

UME:	RM788_34750

» show all

Reference

1 [PMID:26324178]

Authors

Maranha A, Moynihan PJ, Miranda V, Correia Lourenco E, Nunes-Costa D, Fraga JS, Jose Barbosa Pereira P, Macedo-Ribeiro S, Ventura MR, Clarke AJ, Empadinhas N

Title

Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides.

Journal

Sci Rep 5:13610 (2015)
DOI:10.1038/srep13610

Sequence

[mtu:Rv2418c]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.273

IUBMB Enzyme Nomenclature:

2.3.1.273

ExPASy - ENZYME nomenclature database:

2.3.1.273

BRENDA, the Enzyme Database:

2.3.1.273

DBGET integrated database retrieval system