KEGG ENZYME: 2.3.1.276

ENZYME: 2.3.1.276

Entry

EC 2.3.1.276                Enzyme

Name

galactosamine-1-phosphate N-acetyltransferase;
ST0452 (locus name)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:alpha-D-galactosamine-1-phosphate N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R12242]

Reaction(KEGG)

R12242

Substrate

acetyl-CoA [CPD:C00024];
alpha-D-galactosamine 1-phosphate [CPD:C22029]

Product

CoA [CPD:C00010];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]

Comment

The enzyme, characterized from the archaeon Sulfolobus tokodaii, is also active toward alpha-D-glucosamine 1-phosphate (cf. EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase). In addition, that enzyme contains a second domain that catalyses the activities of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase, EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase, and EC 2.7.7.83, UDP-N-acetylgalactosamine diphosphorylase.

History

EC 2.3.1.276 created 2018

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K23144

UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase

Genes

MCAO:

IT6_01180

NVA:	G3M78_13570

KBN:	HYS26_00005

NBN:	HYY55_03975 HYY55_04575

MJA:

MJ_1101

MFE:	Mefer_0780

MVU:	Metvu_1273

MFS:	MFS40622_1224

MIF:	Metin_0997

MJH:	JH146_0795

MESG:

MLAUSG7_0979(glmU)

MESA:

MLASG1_0313(glmU)

MIG:	Metig_0354

MMP:

MMP1076

MMQ:	MmarC5_0513

MMX:	MmarC6_1583

MMZ:	MmarC7_0329

MMD:

GYY_06215

MMAK:

MMKA1_12550

MMAO:

MMOS7_11870

MMAD:

MMJJ_17730(glmU)

MAE:

Maeo_0642

MVN:	Mevan_0399

MVO:

Mvol_0247

MOK:	Metok_0856

METF:

CFE53_04600

MTH:

MTH_1589

MMG:	MTBMA_c01750

MWO:	MWSIV6_0133(glmU)

MTEE:

MTTB_12600

METC:

MTCT_1448

METE:

tca_01538(glmU_3)

METZ:

METMT2_0134

METK:

FVF72_03670

MTHM:

FZP57_00570

METJ:

FZP68_05585

MST:

Msp_1301

METB:

AW729_09130

MEIS:

PXD04_00930(glmU)

MRU:	mru_0456(glmU)

MSI:

Msm_0655

MEB:	Abm4_0226(glmU)

MMIL:

sm9_0316(glmU)

MEYE:

TL18_01350

MOL:

YLM1_0128

MARO:

MarbSA_09660

METV:

K4897_03855

MEL:	Metbo_2293

MEW:	MSWAN_0358

METH:

MBMB1_0406(glmU)

MFC:	BRM9_1856(glmU)

MFI:	DSM1535_0040

MCUB:

MCBB_0372

MSUB:

BK009_00040

METN:

BK008_07835

METT:

CIT01_06535

METO:

CIT02_04785

MEME:

HYG87_07335

MFEG:

GCM10025860_12990

MFV:

Mfer_0129

MKA:

MK0892

AST:	Asulf_01979

FPL:

Ferp_2375

GAC:

GACE_1114

GAH:

GAH_01474

PFU:

PF0235

PFI:

PFC_00225

PHO:	PH1925(PH1925)

PAB:	PAB1115(graD-2)

PYN:

PNA2_0881

PYA:	PYCH_13140

PYS:

Py04_0389

PYC:	TQ32_01175

TKO:

TK1188

TON:

TON_0359

TGA:

TGAM_0642

TSI:

TSIB_1312

TBA:	TERMP_00699

THE:

GQS_03435

THA:

TAM4_697

THM:

CL1_0291

TLT:

OCC_08739

THS:

TES1_0783

TNU:

BD01_0352

TEU:

TEU_07655

TGY:	X802_07040

THV:	ADU37_CDS05730

TCH:	CHITON_0452

TPEP:

A0127_09000

TPIE:

A7C91_07810

TGG:	A3K92_03495

TCE:	A3L02_09590

TBS:	A3L01_02500

THH:	CDI07_02450

TSL:	A3L11_06425

TTD:	A3L14_03965

TPRF:

A3L09_08885

TRL:	A3L10_04085

TPAF:

A3L08_05490

THY:	A3L12_06225

TIC:	FH039_04770

TCQ:	TIRI35C_0723(glmU)

THEM:

FPV09_04390

THEI:

K1720_09670

PPAC:

PAP_06275

MBA:	Mbar_A2020

MBY:	MSBRM_2483

MBW:	MSBRW_2717

MBAR:

MSBR2_2453

MBAK:

MSBR3_2500

MAC:	MA_3025(rfbA)

MMA:

MM_0302

MMAZ:

MmTuc01_0307

MMJ:	MSMAS_0998

MMAC:

MSMAC_2357

MVC:	MSVAZ_1931

MEK:	MSKOL_1916

MLS:	MSLAZ_1276

METM:

MSMTP_2241

MEF:	MSWH1_2137

MEQ:	MSWHS_2961

MSJ:	MSSAC_3286

MSZ:	MSSIH_1143

MSW:	MSSIT_1193

MTHR:

MSTHT_2542

MTHE:

MSTHC_0741

MHOR:

MSHOH_1189

MFZ:	AOB57_002635

MBU:	Mbur_2341(glmU)

MMET:

MCMEM_0484

MELO:

J7W08_00410

MMH:

Mmah_0055

MHAZ:

BHR79_03135

MPOT:

BKM01_05135

MEV:	Metev_2274

MZH:	Mzhil_1657

MPY:

Mpsy_2687

MZI:	HWN40_09290

MMAV:

RE476_00895

MSEB:

RE474_10640

MHZ:	Metho_1847

MTP:

Mthe_0901

MCJ:	MCON_2572(glmU)

MHI:

Mhar_2268

MHU:

Mhun_2853

MRTJ:

KHC33_02680

MLA:

Mlab_0666

MEM:	Memar_2229

MBG:	BN140_1431(glmU2)

MEMA:

MMAB1_1836(rfbA)

MCHK:

MchiMG62_25460

MSUM:

OH143_05430

MRC:	R6Y96_03625

MEND:

L6E24_05400

MEFW:

F1737_07770 F1737_07775

MAQE:

RJ40_07020

MFK:	E2N92_07175

MOU:	OU421_07650

MESB:

L1S32_11035

MANQ:

L1994_08270

MBN:

Mboo_0254

MFO:	Metfor_2859

MPL:

Mpal_0314

MPD:

MCP_0802

MEZ:	Mtc_2010(glmU-2)

RCI:	RCIX1438(rfbA-4)

HAL:	VNG_0009G(graD2)

HSL:	OE_1016R(graD2)

HANR:

LJ422_00055

HDL:	HALDL1_11065

HAGS:

JT689_01700

HABO:

JRZ79_00035

HNO:	LT974_06355

HLU:	LT972_05190 LT972_06675 LT972_06685

HALH:

HTSR_0890(glmU)

HHSR:

HSR6_0623(glmU) HSR6_0906(glmU2)

HSU:	HLASF_0890(glmU)

HSF:	HLASA_0887(glmU)

HAHS:

HSRCO_1680(gcd1-2) HSRCO_1828(gcd1-3)

SALR:

FQU85_07715

HALR:

EFA46_011310

HJE:	HacjB3_01710

HDO:	MUK72_04425

HALX:

M0R89_14165 M0R89_17845 M0R89_21585

HAXZ:

M0R88_14560 M0R88_18190

HAYC:

NGM10_01105 NGM10_15470

HAXY:

NGM07_04380 NGM07_23245

SALI:

L593_04855 L593_11420

SAIM:

K0C01_03520

HARA:

AArcS_0504(gcd1-2) AArcS_0848(gcd1-4)

HMA:	rrnAC1081(rffH1)

HHI:	HAH_1684(rffH2)

HHN:	HISP_08605

HAB:	SG26_16325

HTA:	BVU17_08150

HALJ:

G9465_11675

HSIN:

KDQ40_05000

NPH:	NP_4276A(graD6) NP_4656A(graD2)

NHO:	HWV23_16335

NSAL:

HWV07_01550

HUT:

Huta_2917

HTI:

HTIA_2588

HALA:

Hrd1104_04940

HASV:

SVXHr_1663(gcd1-2)

HABN:

HBNXHr_1645(gcd1-2)

HMU:

Hmuk_2065

HALZ:

E5139_13460

HALL:

LC1Hm_1393

HAZP:

GBQ70_13475

HALI:

BV210_15455 BV210_17765

HSN:	DV733_11360

HDS:	HSR122_0731(gcd1)

HRR:	HZS55_16345

HPEL:

HZS54_19110

HLT:	I7X12_19550

HARC:

HARCEL1_07290 HARCEL1_11810

SSAI:

N0B31_07295

HAAD:

MW046_03485

HWA:	HQ_2992A(graD4)

HWC:	Hqrw_3506(graD4)

HVO:	HVO_A0586(graD3)

HME:	HFX_2130(rffH1) HFX_6127(rffH1) HFX_6312(rffH1)

HGI:	ABY42_17090 ABY42_17735

HALE:

G3A49_06005

HLS:	KU306_15965 KU306_17485

HLN:	SVXHx_2523 SVXHx_4046

HBO:	Hbor_36520

HAQ:	DU484_07230 DU484_15325

HAJ:	DU500_07420 DU500_15345

HAER:

DU502_13420

HRA:	EI982_08225

HLM:	DV707_04355

HALM:

FCF25_01345

HLA:	Hlac_1083 Hlac_2874

HALP:

DOS48_05080

HALB:

EKH57_04995

HEZZ:

EO776_06835

HALQ:

Hrr1229_001610

HSS:	J7656_09830

HSAI:

HPS36_00170

HAZZ:

KI388_04345

HAE:	halTADL_3349

HALN:

B4589_016415

HALG:

HUG10_14685 HUG10_19495 HUG10_21365

HALU:

HUG12_01005 HUG12_01615 HUG12_21255

HMP:	K6T50_17185 K6T50_17195

HRE:	K6T36_14770 K6T36_17300 K6T36_17310

HACB:

Hbl1158_15540 Hbl1158_15550

HDF:	AArcSl_1933(glmU)

HAH:	Halar_2341

HTU:	Htur_1202 Htur_5109

HSAL:

JMJ58_02645 JMJ58_21810

HAKZ:

J0X25_12685 J0X25_20995

NMG:	Nmag_3048(graD2)

HXA:	Halxa_3081

NAT:

NJ7G_3629

NPE:	Natpe_2880

NVR:	FEJ81_06885 FEJ81_13465

NPL:	FGF80_12905

NAY:	HYG81_16615

HALY:

HYG82_00675

HJT:	DVR14_04525

HLO:	J0X27_15140

NGE:	Natgr_3335

HRU:	Halru_1029

SAWL:

NGM29_08885

HALV:

NGM15_01055

NOU:	Natoc_3409

HLR:	HALLA_08700 HALLA_14150

HLC:	CHINAEXTREME04935 CHINAEXTREME16435

NAJ:	B1756_09540

NAG:	AArcMg_1271

NAN:	AArc1_2346

NARA:

QQ977_00170

NBG:	DV706_01385 DV706_15885

NAS:	GCU68_12305

HDA:	BB347_02615

NAC:	AQV86_00490 AQV86_00500

MEAE:

QEN48_01250

MER:	MMINT_02670

ABI:

Aboo_0280

ACF:	AciM339_0783

APE:	APE_1202.1

ACJ:

ACAM_0762

SMR:

Smar_0849

SHC:	Shell_1620

IHO:

Igni_0873

IPC:

IPA_00455

DKA:

DKAM_1334

DFD:	Desfe_1429

DMU:	Desmu_1325

TAG:

Tagg_1347

IAG:

Igag_1093

THG:	TCELL_0401

HBU:

Hbut_1036

PFM:	Pyrfu_1473

PDL:	Pyrde_1774

PABI:

PABY_18660(spn)

PARE:

PYJP_02370(glmU)

STO:

STK_04520

SOH:	D1869_02050

SSO:

SSO0745

SOL:

Ssol_1801

SSOA:

SULA_1827

SSOL:

SULB_1828

SSOF:

SULC_1826

SSHI:

J5U23_02667

SCAS:

SACC_06980

SAI:

Saci_0619

SACN:

SacN8_03010

SACR:

SacRon12I_03000

SACS:

SUSAZ_02815

SIS:	LS215_1492

SIA:	M1425_1397

SIM:	M1627_1447

SID:

M164_1391

SIY:	YG5714_1392

SIN:	YN1551_1451

SII:

LD85_1602

SIH:

SiH_1343

SIR:

SiRe_1265

SIC:

SiL_1256

SULA:

BFU36_02350

SULE:

GFS03_07855

SULO:

GFS33_13280

SULL:

EWF20_03570

MSE:

Msed_0068

MEMJ:

MJ1HA_0154

MCN:

Mcup_1988

MHK:	DFR87_06630

MPRU:

DFR88_06325

MTEN:

GWK48_05495

MJN:	MjAS7_0658

AHO:

Ahos_0822

AMAN:

B6F84_07610

ABRI:

DFR85_07220

ASUL:

DFR86_06655

AAMB:

D1866_11985

ACIH:

HS5_21960

SACD:

HS1genome_0199

SAZO:

D1868_02105

CSTY:

KN1_19100

STEP:

IC006_1737

SMET:

RQ359_000105(spn)

SAHS:

HS7_08090

ASC:

ASAC_1091

ACIA:

SE86_06590

CLG:	Calag_0445

FFO:	FFONT_0438

CSU:	CSUB_C1499

KCR:

Kcr_1379

BARC:

AOA65_1819(glmU_2)

BARB:

AOA66_1497(glmU_3)

FLT:	Sv326_0194

NCON:

LC1Nh_1149(glmU) LC1Nh_1150(glmU2)

LOKI:

Lokiarch_02940(glmU_1) Lokiarch_26580(glmU_5)

LOB:	NEF87_000117 NEF87_001245

PSYT:

DSAG12_02719(glmU_4)

AGW:	QT03_C0001G0478 QT03_C0001G1263

» show all

Reference

1 [PMID:15598657]

Authors

Zhang Z, Tsujimura M, Akutsu J, Sasaki M, Tajima H, Kawarabayasi Y

Title

Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7.

Journal

J Biol Chem 280:9698-705 (2005)
DOI:10.1074/jbc.M411211200

Reference

2 [PMID:20400541]

Authors

Zhang Z, Akutsu J, Kawarabayasi Y

Title

Identification of novel acetyltransferase activity on the thermostable protein ST0452 from Sulfolobus tokodaii strain 7.

Journal

J Bacteriol 192:3287-93 (2010)
DOI:10.1128/JB.01683-09

Sequence

[sto:STK_04520]

Reference

3 [PMID:29507091]

Authors

Dadashipour M, Iwamoto M, Hossain MM, Akutsu JI, Zhang Z, Kawarabayasi Y

Title

Identification of a Direct Biosynthetic Pathway for UDP-N-Acetylgalactosamine from Glucosamine-6-Phosphate in Thermophilic Crenarchaeon Sulfolobus tokodaii.

Journal

J Bacteriol 200:e00048-18 (2018)
DOI:10.1128/JB.00048-18

Sequence

[sto:STK_04520]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.276

IUBMB Enzyme Nomenclature:

2.3.1.276

ExPASy - ENZYME nomenclature database:

2.3.1.276

BRENDA, the Enzyme Database:

2.3.1.276

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1437)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (400)   
   KEGG MGENES (1036)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (7)   
   InterPro (7)   
All databases (1457)   

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