KEGG   ENZYME: 2.3.1.277
Entry
EC 2.3.1.277                Enzyme                                 
Name
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase;
afsA (gene name);
scbA (gene name);
barX (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase
Reaction(IUBMB)
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein] [RN:R12289]
Reaction(KEGG)
R12289
Substrate
medium-chain 3-oxoacyl-[acyl-carrier protein] [CPD:C22064];
glycerone phosphate [CPD:C00111]
Product
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate [CPD:C22065];
holo-[acyl-carrier protein] [CPD:C00229]
Comment
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
History
EC 2.3.1.277 created 2018
Orthology
K22463  2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase
Genes
YRE: HEC60_12875
TOE: QMG90_05975
PROD: PCO85_08030
AMAH: DLM_1345
PBH: AAW51_3063
MPAG: C0J29_24015
MAIC: MAIC_49490
MPAE: K0O64_03280
MCRO: MI149_03875
CSX: CSING_09340
NCY: NOCYR_1429
NBR: O3I_009095 O3I_022440 O3I_026160
NNO: NONO_c59160
NSR: NS506_05283
NTP: CRH09_04845 CRH09_10155 CRH09_19790
NOZ: DMB37_02530 DMB37_29865
NOD: FOH10_10135
NAH: F5544_11680
NWL: NWFMUON74_54410
NIE: KV110_09630 KV110_16520 KV110_22410
NHU: H0264_14695
NYA: LTV02_03870 LTV02_18435
NSPU: IFM12276_25010
NYU: D7D52_08100
RHA: RHA1_ro04614
RER: RER_54010
REY: O5Y_25660
REB: XU06_26000
RQI: C1M55_27235
ROP: ROP_45600
ROA: Pd630_LPD01099 Pd630_LPD06644
RHB: NY08_569
RAV: AAT18_22295
RFA: A3L23_03815 A3L23_04925
RHS: A3Q41_04426
RRZ: CS378_12125
RHQ: IM25_24585
RHOD: AOT96_07205
RRT: 4535765_02640
RTM: G4H71_11170
RKO: JWS14_25400
RPSK: JWS13_19140
RGOR: NMQ04_10800
REQ: REQ_44790
WHR: OG579_14335
GPO: GPOL_c20770 GPOL_c49040
SCO: SCO6266(SCAH10.31) SCP1.243(mmfL)
SMA: SAVERM_2269(avaA)
SGR: SGR_6889(afsA)
SGB: WQO_00740
SFI: SFUL_271
SANL: KZO11_00310 KZO11_19690
SGRF: SGFS_035700 SGFS_040850 SGFS_079640 SGFS_079870
SCYE: R2B67_04425 R2B67_35415
SCB: SCAB_12081 SCAB_63031 SCAB_63111
SSX: SACTE_3173 SACTE_6321
SVL: Strvi_3600
SHY: SHJG_4004 SHJG_7319 SHJG_8650
SHO: SHJGH_3769 SHJGH_7079 SHJGH_8410
SRC: M271_03790 M271_07485
SMAL: SMALA_6930 SMALA_7619
SSOI: I1A49_38425 I1A49_41870
SFA: Sfla_3302 Sfla_6323
SBH: SBI_08929
SVE: SVEN_4183 SVEN_5969
SDV: BN159_2279 BN159_4440
SALS: SLNWT_0249 SLNWT_2752 SLNWT_4679
STRP: F750_0224(afsA) F750_3441(afsA)
SLV: SLIV_06815(afsA)
SGU: SGLAU_25495
SVT: SVTN_03085 SVTN_03460 SVTN_29875
STRE: GZL_00107 GZL_01281 GZL_01594 GZL_09306
SCW: TU94_11455
SLD: T261_0487 T261_2144
SLC: SL103_20520 SL103_26350
SXI: SXIM_17800
STRM: M444_36350 M444_36565 M444_38055
SAMB: SAM23877_0232
SCZ: ABE83_19750 ABE83_34265
SCX: AS200_21945 AS200_24410 AS200_44220
SRW: TUE45_05044 TUE45_pSRc_0609(TUE45_pSRTUE45c_0609)
SLE: sle_45960(sle_45960)
SRN: A4G23_05421
SPAV: Spa2297_32650
STRT: A8713_01240
SCLF: BB341_16850 BB341_25515
SGS: AVL59_00695
STSI: A4E84_21260
SALW: CP975_23005
SCAD: DN051_10570
SPHW: NFX46_09900 NFX46_12245
SLS: SLINC_5092 SLINC_6540
SNR: SNOUR_05455 SNOUR_06740
SALU: DC74_5978 DC74_7047 DC74_7321 DC74_7607
SALL: SAZ_30970 SAZ_36560 SAZ_37915 SAZ_39250
SPLU: LK06_017405
STRD: NI25_18850
SNW: BBN63_07420 BBN63_21870 BBN63_24955
SAUO: BV401_38280
SSIA: A7J05_00415 A7J05_00570 A7J05_13280 A7J05_36165 A7J05_36320
SVU: B1H20_00410 B1H20_15505
SPUN: BFF78_11405
SGV: B1H19_37530
SLAU: SLA_3053
SALF: SMD44_04059 SMD44_04421
SALJ: SMD11_3339 SMD11_6032
SLX: SLAV_20865 SLAV_40300
STRO: STRMOE7_29285 STRMOE7_35135
SFK: KY5_6104c
SNZ: DC008_13210 DC008_27305
SGE: DWG14_02015
SRJ: SRO_3382
SDX: C4B68_08540 C4B68_08560
SGD: ELQ87_36110
SCYA: EJ357_14630 EJ357_16305 EJ357_35240 EJ357_36165
SAST: CD934_15305
SNQ: CP978_34585
STIR: DDW44_16615 DDW44_31525
SKA: CP970_10415
SGZ: C0216_31320 C0216_31805
SNK: CP967_04275 CP967_15135 CP967_17825 CP967_30545 CP967_30560 CP967_31560
SHAW: CEB94_20765
SRK: FGW37_31685
SFIC: EIZ62_19125 EIZ62_31530
SGAL: CP966_28410
SSPO: DDQ41_04315 DDQ41_08110 DDQ41_31065
SVR: CP971_19130 CP971_26335
SPAD: DVK44_28100 DVK44_34195
SFY: GFH48_20475 GFH48_38925
SAQU: EJC51_22105 EJC51_25725 EJC51_43860
SGF: HEP81_03594 HEP81_07959
SCAV: CVT27_00255 CVT27_14835
SSEO: D0Z67_22095
SBY: H7H31_04615
SRIM: CP984_08935 CP984_23685 CP984_38960
SSUB: CP968_00750 CP968_02880 CP968_15830 CP968_33915
SPHV: F9278_17975
SCIN: CP977_27350 CP977_28615
SPAC: B1H29_00920 B1H29_36145
STSU: B7R87_00235 B7R87_00255
SCHA: CP983_09845 CP983_27850
SGX: H4W23_30995
SCOE: CP976_22215 CP976_30025 CP976_32365
SBAT: G4Z16_00070
SNF: JYK04_00153 JYK04_01859
SPLA: CP981_29465 CP981_30955 CP981_35585
STUI: GCM10017668_35390(mmfL) GCM10017668_35620
SATA: C5746_12505
SCHF: IPT68_15530 IPT68_28530 IPT68_29305
SHUN: DWB77_00550 DWB77_04718
SHAR: HUT13_05645
SCYG: S1361_31310
SFEU: IM697_07635 IM697_32675
SLIA: HA039_01285 HA039_05325 HA039_14005 HA039_29945
SDW: K7C20_10825 K7C20_28250 K7C20_34355
SCAL: I6J39_00530 I6J39_15520
SAUH: SU9_026870 SU9_030680 SU9_031850 SU9_032980
SFB: CP974_28860
SROI: IAG44_08745 IAG44_35000
SXN: IAG42_22440
SGJ: IAG43_25740 IAG43_33485
SHK: J2N69_15050 J2N69_24035
SANU: K7396_00440 K7396_02020 K7396_07590 K7396_08770
STRY: EQG64_15560
SDD: D9753_06795 D9753_09135
SACT: DMT42_11890 DMT42_14060 DMT42_19780 DMT42_29840
SMAO: CAG99_00900
SINE: KI385_40060
SDEC: L3078_43220
SAOV: G3H79_22390
SYAN: NRK68_34925
SAKB: K1J60_19015 K1J60_44780
STAA: LDH80_09315
SNIG: HEK616_39440 HEK616_50970
SSPN: LXH13_23620 LXH13_30520
SCIR: STRCI_004204 STRCI_006306
SXT: KPP03845_300021
SLON: LGI35_17500 LGI35_23850 LGI35_23895
SDRZ: NEH16_22700 NEH16_31525 NEH16_31970 NEH16_32560
STUD: STRTU_000345 STRTU_001581 STRTU_007117
SENG: OJ254_24765 OJ254_30330
SGK: PET44_33790 PET44_34005 PET44_34835
SANT: QR300_06555
SYUN: MOV08_00435 MOV08_05540 MOV08_06650 MOV08_43530
SARG: HKX69_17125
SJN: RI060_08575 RI060_20740
SCYN: N8I84_14930 N8I84_31960
SOV: QZH56_09430 QZH56_16815
SFIY: F0344_18560 F0344_34650 F0344_34840
SHAU: K9S39_02735
SKG: KJK29_13055 KJK29_13160 KJK29_13465 KJK29_18465
SCOA: QU709_08700 QU709_09100
SLAI: P8A22_27830
SROC: RGF97_13695
SFP: QUY26_00290 QUY26_19155 QUY26_20885
SCHG: NRO40_22940
STTN: BSL84_17800
SINN: ABB07_25600 ABB07_37440 ABB07_38890
STRZ: OYE22_02930 OYE22_04425
SCT: SCAT_0001 SCAT_2185(afsA) SCAT_5778 SCAT_p0948
SCY: SCATT_21660 SCATT_57810 SCATT_p07910
KSK: KSE_01060t(ksbS2L) KSE_08560 KSE_22970(ksbS3) KSE_44600(ksbS4) KSE_58120 KSE_75680t(ksbS2R)
KAB: B7C62_00290
KAU: B6264_02795 B6264_13770 B6264_20890
KIT: CFP65_3606 CFP65_4017
KIS: HUT16_21005
STRI: C7M71_001450 C7M71_007220
STRH: GXP74_01210 GXP74_06785 GXP74_19350 GXP74_38570
RIA: C7V51_14130
ASOI: MTP13_02140
ALAV: MTO99_11590
AGX: AGREI_0437
ARR: ARUE_c35120
AWW: G8758_06600
AAU: AAur_3376
RDN: HMPREF0733_10613
BCAU: I6G59_16805
NDA: Ndas_3370
NGV: CDO52_02955
NEX: NE857_20455
NAKE: KGD83_08230
NCG: KGD84_11165
SNAH: OUQ99_07015 OUQ99_10120
NGN: LCN96_20855
NFS: OIE67_15245
MHAI: OHB01_25095
FRA: Francci3_2120
BSD: BLASA_0744
SACG: FDZ84_25550
AMYC: CU254_30050
AAB: A4R43_32240
AMYY: YIM_46150
ARHD: VSH64_26350 VSH64_43870
SSYI: EKG83_10415
KAL: KALB_5811
KUT: JJ691_07420 JJ691_08030 JJ691_18280
KBU: Q4V64_10435 Q4V64_40370
AHM: TL08_24095
CROS: N8J89_39685
UME: RM788_45915
STP: Strop_4151
SAQ: Sare_3017
MSAG: GCM10017556_32740
ACTN: L083_0231
PRY: Prubr_43810
ALIL: D5R93_00295
AEY: CDG81_10645 CDG81_11415
 » show all
Reference
1  [PMID:2492509]
  Authors
Horinouchi S, Suzuki H, Nishiyama M, Beppu T
  Title
Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis.
  Journal
J Bacteriol 171:1206-10 (1989)
DOI:10.1128/JB.171.2.1206-1210.1989
  Sequence
[sgr:SGR_6889]
Reference
2  [PMID:17277085]
  Authors
Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S
  Title
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
  Journal
Proc Natl Acad Sci U S A 104:2378-83 (2007)
DOI:10.1073/pnas.0607472104
Reference
3  [PMID:17464053]
  Authors
Hsiao NH, Soding J, Linke D, Lange C, Hertweck C, Wohlleben W, Takano E
  Title
ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and  is able to synthesize gamma-butyrolactones.
  Journal
Microbiology 153:1394-404 (2007)
DOI:10.1099/mic.0.2006/004432-0
  Sequence
[sco:SCO6266]
Reference
4  [PMID:19778967]
  Authors
Lee YJ, Kitani S, Nihira T
  Title
Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the {gamma}-butyrolactone autoregulator in Streptomyces virginiae.
  Journal
Microbiology 156:206-10 (2010)
DOI:10.1099/mic.0.032003-0
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.277
IUBMB Enzyme Nomenclature: 2.3.1.277
ExPASy - ENZYME nomenclature database: 2.3.1.277
BRENDA, the Enzyme Database: 2.3.1.277

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (510)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (428)   
   KEGG MGENES (81)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (3)   
   InterPro (3)   
All databases (528)   

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