KEGG ENZYME: 2.3.1.279

ENZYME: 2.3.1.279

Entry

EC 2.3.1.279                Enzyme

Name

long-chain-acyl-CoA---trehalose acyltransferase;
papA3 (gene name)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

long-chain-fatty acyl-CoA:alpha,alpha-trehalose 2-acyltransferase

Reaction(IUBMB)

a long-chain-fatty acyl-CoA + alpha,alpha-trehalose = a 2-(long-chain-fatty acyl)-trehalose + CoA [RN:R12287]

Reaction(KEGG)

R12287

Substrate

long-chain-fatty acyl-CoA [CPD:C02843];
alpha,alpha-trehalose [CPD:C01083]

Product

2-(long-chain-fatty acyl)-trehalose [CPD:C22061];
CoA [CPD:C00010]

Comment

The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase).

History

EC 2.3.1.279 created 2018

Orthology

K23156

mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase / long-chain-acyl-CoA---trehalose acyltransferase

Genes

BRAD:

BF49_6970

BRQ:	CIT40_12665

BSYM:

CIT39_22775

BCAN:

BcanWSM471_20440

MTU:	Rv1182(papA3)

MTV:

RVBD_1182

MTC:

MT1219

MRA:	MRA_1192(papA3)

MTF:	TBFG_11206

MTB:	TBMG_02800

MTK:	TBSG_02814

MTZ:	TBXG_002780

MTG:	MRGA327_07450

MTE:	CCDC5079_1093

MTUR:

CFBS_1260(papA3)

MTL:	CCDC5180_1086

MTO:	MTCTRI2_1213(papA3)

MTD:	UDA_1182(papA3)

MTN:	ERDMAN_1324(papA3)

MTJ:	J112_06385

MTUB:

MT7199_1211

MTUC:

J113_08295

MTUE:

J114_06385

MTX:	M943_06190

MTUH:

I917_08405

MTUL:

TBHG_01165

MTUT:

HKBT1_1258(papA3)

MTUU:

HKBT2_1264(papA3)

MTQ:	HKBS1_1262(papA3)

MBO:	BQ2027_MB1214(papA3)

MBB:	BCG_1244(papA3)

MBT:	JTY_1217(papA3)

MBM:	BCGMEX_1216(papA3)

MBK:	K60_012740

MBX:

BCGT_1013

MAF:	MAF_12010(papA3)

MMIC:

RN08_1326

MCE:	MCAN_11931(papA3)

MCQ:	BN44_11321(papA)

MCV:	BN43_30249(papA)

MCX:	BN42_21047(papA)

MCZ:	BN45_30244(papA)

MORY:

MO_001272(papA3)

MLE:	ML1230(papA3)

MLB:	MLBr01230(papA3)

MPA:	MAP_2231(papA3) MAP_3721 MAP_3763c(papA3)

MAO:	MAP4_0048 MAP4_1593 MAP4_3872

MAVI:

RC58_00225 RC58_07935 RC58_19220

MAVU:

RE97_00230 RE97_07935 RE97_19270

MAV:	MAV_1762 MAV_4883

MIT:	OCO_18180 OCO_47930

MIA:	OCU_18360 OCU_47860

MID:	MIP_02565 MIP_07251

MYO:	OEM_16190 OEM_48100

MCHI:

AN480_08940 AN480_24900

MIR:	OCQ_15790 OCQ_48950

MMAL:

CKJ54_07815 CKJ54_22825 CKJ54_22835

MLP:

MLM_2749

MMAN:

MMAN_23420 MMAN_36120 MMAN_40010(papA3)

MSA:	Mycsm_00207

MUL:	MUL_1531(papA3)

MMI:	MMAR_2343 MMAR_2355(papA3)

MMAE:

MMARE11_22650 MMARE11_22770(papA3)

MLI:	MULP_03269(papA3)

MPSE:

MPSD_23880

MSHO:

MSHO_35730

MMC:	Mmcs_0245 Mmcs_3118

MKM:	Mkms_0255 Mkms_3178

MJL:	Mjls_0235 Mjls_3129

MMM:	W7S_07745 W7S_24030

MKN:	MKAN_27535 MKAN_27610

MYV:	G155_01575 G155_14370

MYE:	AB431_02010 AB431_13675

MHAD:

B586_07470 B586_12980

MDX:	BTO20_18245 BTO20_34435

MSHG:

MSG_03264 MSG_03826(papA3)

MFJ:	MFLOJ_45790 MFLOJ_52900

MSTO:

MSTO_49700 MSTO_57010

MSIM:

MSIM_42160

MSAK:

MSAS_03080(papA3_1) MSAS_16200 MSAS_21090(papA3_2)

MKU:	I2456_11550 I2456_18040

MLW:	MJO58_18830 MJO58_22755

MNV:	MNVI_38120

MPAG:

C0J29_13265 C0J29_20850

MGOR:

H0P51_12600 H0P51_12615 H0P51_18890

MCOO:

MCOO_14710

MBAI:

MB901379_02178(papA2) MB901379_02191(papA1)

MSEO:

MSEO_22230 MSEO_43720

MLJ:	MLAC_13990(papA3) MLAC_14010(papA2)

MBRD:

MBRA_33990

MSHJ:

MSHI_16720(papA2) MSHI_16740(papA3)

MMAM:

K3U93_10360 K3U93_10750 K3U93_15990

MSPG:

F6B93_01470 F6B93_09730

MOT:	LTS72_12605 LTS72_12670

MLM:	MLPF_1674(papA3)

MPAA:

MKK62_08600 MKK62_13550

MMEH:

M5I08_11350 M5I08_12885

MKY:	IWGMT90018_20670

MADI:

A7U43_00980 A7U43_17265

MWU:	PT015_04290 PT015_08400

MSM:	MSMEG_0409 MSMEG_4728

MSG:	MSMEI_0399(papA3) MSMEI_4611

MSB:	LJ00_02035 LJ00_23390

MSN:	LI99_02035 LI99_23395

MSH:	LI98_02035 LI98_23400

MVA:

Mvan_0270

MGI:

Mflv_0404

MSP:	Mspyr1_03510

MCB:	Mycch_0237

MNE:	D174_03070 D174_13550

MYN:	MyAD_03000 MyAD_13300

MFT:	XA26_03380 XA26_29750

MPHL:

MPHLCCUG_00973(papA3_1) MPHLCCUG_04852(papA3_2)

MVQ:

MYVA_0272

MLL:	B1R94_01625 B1R94_15670

MRH:	MycrhN_2273

MTHN:

4412656_01985(papA1)

MDU:	MDUV_40530

MCHT:

MCHIJ_06870

MDR:	MDOR_22950

MAUU:

NCTC10437_00273(papA1) NCTC10437_02583(papA2)

MMAG:

MMAD_05470(papA3) MMAD_26460

MMOR:

MMOR_12060

MFX:	MFAL_06690

MAIC:

MAIC_24560 MAIC_52950

MIJ:	MINS_17880 MINS_24730

MALV:

MALV_32520

MTY:	MTOK_44810

MARZ:

MARA_13110 MARA_35290

MHEV:

MHEL_18590 MHEL_49060

MSAR:

MSAR_19040 MSAR_43810

MANY:

MANY_11070 MANY_44020

MAUB:

MAUB_03850 MAUB_36870

MPOF:

MPOR_08100

MPHU:

MPHO_08990 MPHO_33530

MMUC:

C1S78_001325 C1S78_013710

MMAT:

MMAGJ_18030 MMAGJ_61730

MBOK:

MBOE_15660 MBOE_44840

MFG:	K6L26_17660 K6L26_29830

MSEI:

MSEDJ_38500

MFLV:

NCTC10271_04865(papA3)

MCEE:

MCEL_29780

MMON:

EWR22_01325 EWR22_16465

MGO:	AFA91_08980 AFA91_16880 AFA91_22635

MHOL:

K3U96_05125 K3U96_25255

MSEN:

K3U95_01625 K3U95_12065

MPAE:

K0O64_01645 K0O64_13480

MRF:	MJO55_01280

MDF:	K0O62_02035 K0O62_13850

MCRO:

MI149_02190 MI149_14305

MGRO:

FZ046_08055 FZ046_18575

MPAK:

MIU77_05275

MAB:	MAB_0938c MAB_3147c

MMV:	MYCMA_0490 MYCMA_1726

MABB:

MASS_0922 MASS_3090

MABL:

MMASJCM_0855 MMASJCM_3150

MCHE:

BB28_04245 BB28_15930

MIZ:	BAB75_05045

MSTE:

MSTE_00844 MSTE_03124

MSAO:

MYCSP_03820 MYCSP_14310

MSAL:

DSM43276_00773(papA3_1) DSM43276_02932(papA3_2)

MMIN:

MMIN_17130(papA3)

MHIB:

MHIB_35860(papA3)

MVM:	MJO54_23315

» show all

Reference

1 [PMID:19276083]

Authors

Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR

Title

PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.

Journal

J Biol Chem 284:12745-51 (2009)
DOI:10.1074/jbc.M809088200

Sequence

[mtu:Rv1182]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.279

IUBMB Enzyme Nomenclature:

2.3.1.279

ExPASy - ENZYME nomenclature database:

2.3.1.279

BRENDA, the Enzyme Database:

2.3.1.279

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (258)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (257)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (2)   
   InterPro (2)   
All databases (273)   

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