Entry
Name
(aminoalkyl)phosphonate N-acetyltransferase;
phnO (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:(aminomethyl)phosphonate N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + (aminomethyl)phosphonate = CoA + (acetamidomethyl)phosphonate [RN:
R11479 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
aminomethylphosphonate [CPD:
C11033 ]
Product
CoA [CPD:
C00010 ];
(acetamidomethyl)phosphonate
Comment
The enzyme, characterized from the bacterium Escherichia coli, is able to acetylate a range of (aminoalkyl)phosphonic acids. Requires a divalent metal ion for activity.
History
EC 2.3.1.280 created 2018
Pathway
ec00440 Phosphonate and phosphinate metabolism
Orthology
K09994 (aminoalkyl)phosphonate N-acetyltransferase
Genes
ECOO : ECRM13514_5309(phnO)
ECOH : ECRM13516_4977(phnO)
EDJ : ECDH1ME8569_3952(phnO)
CCK : Ccar_24530 Ccar_24570
CDRK : B9W14_03185 B9W14_03245
» show all
Taxonomy
Reference
Authors
Errey JC, Blanchard JS
Title
Functional annotation and kinetic characterization of PhnO from Salmonella enterica.
Journal
Sequence
Reference
Authors
Hove-Jensen B, McSorley FR, Zechel DL
Title
Catabolism and detoxification of 1-aminoalkylphosphonic acids: N-acetylation by the phnO gene product.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.280