KEGG   ENZYME: 2.3.1.296
Entry
EC 2.3.1.296                Enzyme                                 
Name
omega-hydroxyceramide transacylase;
PNPLA1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
triacyl-sn-glycerol:ultra-long-chain omega-hydroxyceramide omega-O-linoleoyltransferase
Reaction(IUBMB)
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide = a diacyl-sn-glycerol + a linoleate-esterified acylceramide
Substrate
linoleate-containing triacyl-sn-glycerol;
ultra-long-chain omega-hydroxyceramide
Product
diacyl-sn-glycerol;
linoleate-esterified acylceramide
Comment
The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier.
History
EC 2.3.1.296 created 2019
Orthology
K16813  omega-hydroxyceramide transacylase
Genes
HSA: 285848(PNPLA1)
PTR: 471991(PNPLA1)
PPS: 100981874(PNPLA1)
GGO: 101149146(PNPLA1)
PON: 100450832(PNPLA1)
NLE: 100596271(PNPLA1)
HMH: 116459954(PNPLA1)
MCC: 100426523(PNPLA1)
MCF: 102142984(PNPLA1)
MTHB: 126952765
MNI: 105474519(PNPLA1)
CSAB: 103221593(PNPLA1)
CATY: 105593818(PNPLA1)
PANU: 101025463(PNPLA1)
TGE: 112623430(PNPLA1)
MLEU: 105544224(PNPLA1)
RRO: 104682872(PNPLA1)
RBB: 108528307(PNPLA1)
TFN: 117087124(PNPLA1)
PTEH: 111542888(PNPLA1)
CANG: 105514172(PNPLA1)
CJC: 100415082(PNPLA1)
SBQ: 101044461(PNPLA1)
CIMI: 108300000(PNPLA1)
CSYR: 103265296(PNPLA1)
MMUR: 105861455(PNPLA1)
LCAT: 123632080(PNPLA1)
PCOQ: 105812192(PNPLA1)
OGA: 100957737(PNPLA1)
MMU: 433091(Pnpla1)
MCAL: 110283928(Pnpla1)
MPAH: 110338533(Pnpla1)
RNO: 361812(Pnpla1)
MCOC: 116075243(Pnpla1)
ANU: 117724871(Pnpla1)
MUN: 110546583(Pnpla1)
CGE: 100763234(Pnpla1)
MAUA: 101831359(Pnpla1)
PROB: 127223908(Pnpla1)
PLEU: 114706161(Pnpla1)
MORG: 121435720(Pnpla1)
MFOT: 126502532
AAMP: 119823834(Pnpla1)
NGI: 103739726(Pnpla1)
HGL: 101713574(Pnpla1)
CPOC: 100728999(Pnpla1)
CCAN: 109689861(Pnpla1)
DORD: 105995744(Pnpla1)
DSP: 122111147(Pnpla1)
PLOP: 125353506(Pnpla1)
NCAR: 124987961
MMMA: 107143844(Pnpla1)
OCU: 100339908
OPI: 101521491(PNPLA1)
TUP: 102494197(PNPLA1)
GVR: 103607576(PNPLA1)
CFA: 481763(PNPLA1)
CLUD: 112641486(PNPLA1)
VVP: 112913935(PNPLA1)
VLG: 121495666(PNPLA1)
NPO: 129512665(PNPLA1)
AML: 100464720(PNPLA1)
UMR: 103665449(PNPLA1)
UAH: 113243858(PNPLA1)
UAR: 123779568(PNPLA1)
ELK: 111152378
LLV: 125103227
MPUF: 101685859(PNPLA1)
MNP: 132017211(PNPLA1)
MLK: 131834186(PNPLA1)
NVS: 122909994(PNPLA1)
ORO: 101376548(PNPLA1)
EJU: 114222073(PNPLA1)
ZCA: 113927076(PNPLA1)
MLX: 118001200(PNPLA1)
NSU: 110575676(PNPLA1)
LWW: 102727615(PNPLA1)
FCA: 101091788(PNPLA1)
PYU: 121029358(PNPLA1)
PBG: 122490352(PNPLA1)
PVIV: 125165871(PNPLA1)
LRUF: 124529284
PTG: 102966751(PNPLA1)
PPAD: 109271519(PNPLA1)
PUC: 125938316
AJU: 106972772
HHV: 120233831(PNPLA1)
BTA: 786888(PNPLA1)
BOM: 102270258(PNPLA1)
BIU: 109577451(PNPLA1)
BBUB: 102398763(PNPLA1)
BBIS: 104994942(PNPLA1)
CHX: 102189446(PNPLA1)
OAS: 101120362(PNPLA1)
BTAX: 128055138(PNPLA1)
ODA: 120870207(PNPLA1)
CCAD: 122429581(PNPLA1)
MBEZ: 129543798(PNPLA1)
SSC: 100154642(PNPLA1)
CFR: 102512995(PNPLA1)
CBAI: 105064172(PNPLA1)
CDK: 105101336(PNPLA1)
VPC: 102528081(PNPLA1)
BACU: 103007961(PNPLA1)
BMUS: 118904197(PNPLA1)
LVE: 103087327(PNPLA1)
OOR: 101285071(PNPLA1)
DLE: 111178608(PNPLA1)
PCAD: 102990565(PNPLA1)
ECB: 100063661(PNPLA1)
EPZ: 103563196(PNPLA1)
EAI: 106824602(PNPLA1)
MYB: 102247326(PNPLA1)
MYD: 102756555(PNPLA1)
MMYO: 118660076(PNPLA1)
MLF: 102442402(PNPLA1)
PKL: 118705841(PNPLA1)
EFUS: 103295576(PNPLA1)
MNA: 107545587(PNPLA1)
DRO: 112302420(PNPLA1)
SHON: 118998969(PNPLA1)
AJM: 119050074(PNPLA1)
PDIC: 114495514(PNPLA1)
PHAS: 123822263(PNPLA1)
MMF: 118621825(PNPLA1)
PPAM: 129067009(PNPLA1)
HAI: 109395975(PNPLA1)
RFQ: 117015543(PNPLA1)
PALE: 102898567(PNPLA1)
PGIG: 120597573(PNPLA1)
PVP: 105288542(PNPLA1)
RAY: 107514707(PNPLA1)
MJV: 108390133(PNPLA1)
TOD: 119253297(PNPLA1)
SARA: 101540597(PNPLA1)
LAV: 100672854(PNPLA1)
TMU: 101340560
ETF: 101658379(PNPLA1)
DNM: 101433422(PNPLA1)
MDO: 100028911(PNPLA1)
GAS: 123247070(PNPLA1)
SHR: 100927942(PNPLA1)
AFZ: 127561335
PCW: 110217314(PNPLA1)
OAA: 114813289(PNPLA1)
GGA: 428259(PNPLA1)
PCOC: 116236969 116236970(PNPLA1)
MGP: 100542403 100542559(PNPLA1)
CJO: 107324687(PNPLA1) 107324688
TPAI: 128087973(PNPLA1) 128088193
LMUT: 125684261(PNPLA1)
NMEL: 110388084 110388095(PNPLA1)
APLA: 119713935(PNPLA1)
ACYG: 106048433(PNPLA1)
CATA: 118260418(PNPLA1)
AFUL: 116498701(PNPLA1)
TGU: 100225038(PNPLA1) 115498565
LSR: 110473035(PNPLA1)
SCAN: 103822414(PNPLA1) 108963115
PMOA: 120497628(PNPLA1)
OTC: 121345513(PNPLA1) 121345514
PRUF: 121349761(PNPLA1)
GFR: 102032738 102041930(PNPLA1)
FAB: 101809281(PNPLA1) 101817044
OMA: 130263836(PNPLA1)
PHI: 102109501 102113209(PNPLA1)
PMAJ: 107214760 107215020(PNPLA1)
CCAE: 111939875(PNPLA1) 111939878
CCW: 104692425(PNPLA1) 109145293
CBRC: 103619070(PNPLA1)
ETL: 114064790(PNPLA1)
ZAB: 102065438(PNPLA1)
ACHL: 103807326
SVG: 106850933(PNPLA1)
MMEA: 130578840(PNPLA1)
HRT: 120762871(PNPLA1) 120762965
FPG: 101920072(PNPLA1)
FCH: 102058013 114018075
CLV: 102097663(PNPLA1) 110364654
EGZ: 104131423(PNPLA1)
NNI: 104018436 104018437
PCRI: 104029985
PLET: 104621756(PNPLA1)
EHS: 104509992
PCAO: 104042537
ACUN: 113489012(PNPLA1)
TALA: 104359130(PNPLA1)
PADL: 103925952 103925953(PNPLA1)
AFOR: 103908270(PNPLA1)
ACHC: 115335218(PNPLA1)
HALD: 104315359(PNPLA1)
HLE: 104842451(PNPLA1)
AGEN: 126052237
GCL: 127026112
CCRI: 104167251(PNPLA1)
CSTI: 104557167(PNPLA1)
MUI: 104538299(PNPLA1)
BREG: 104640222 104640223
FGA: 104072992
GSTE: 104261051
LDI: 104343121
MNB: 103781500(PNPLA1)
OHA: 104328255(PNPLA1)
NNT: 104405411
SHAB: 115602465 115602466
DPUB: 104304948(PNPLA1)
PGUU: 104468912
CPEA: 104392036(PNPLA1)
AVIT: 104277765(PNPLA1)
CVF: 104292376(PNPLA1)
RTD: 128900454(PNPLA1)
TEO: 104383376
BRHI: 104496009
AROW: 112961441(PNPLA1)
NPD: 112944597(PNPLA1)
TGT: 104566832(PNPLA1)
DNE: 112990369(PNPLA1)
SCAM: 104142550(PNPLA1)
ASN: 102381144 102381898 102387352 102387599 112550535
AMJ: 102574209 102574443
CPOO: 109317520 109317522
GGN: 109295081 109295082
PSS: 102452905 102453155
CMY: 102931927 102932153
CCAY: 125624991 125624993
DCC: 119846262 119846540
CPIC: 101931701 101931995
TST: 117876544 117876814
CABI: 116839152 116839161
MRV: 120404008 120404009
ACS: 100553180 100568175
ASAO: 132773752
PVT: 110085293
SUND: 121929456
VKO: 123024271
PMUA: 114599195
PRAF: 128415974
ZVI: 118089181
HCG: 128324113
GJA: 107110977(PNPLA1)
XLA: 108708055(pnpla1.L) 108709386(pnpla1.S)
XTR: 100497390(pnpla1)
NPR: 108800152
RTEM: 120927014
BBUF: 120995056
BGAR: 122931630 122933399
HOC: 132828259
LERI: 129708799
PMRN: 116937180
PJA: 122261361
 » show all
Reference
1  [PMID:28248318]
  Authors
Ohno Y, Kamiyama N, Nakamichi S, Kihara A
  Title
PNPLA1 is a transacylase essential for the generation of the skin barrier lipid omega-O-acylceramide.
  Journal
Nat Commun 8:14610 (2017)
DOI:10.1038/ncomms14610
  Sequence
[hsa:285848]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.296
IUBMB Enzyme Nomenclature: 2.3.1.296
ExPASy - ENZYME nomenclature database: 2.3.1.296
BRENDA, the Enzyme Database: 2.3.1.296

  All links  
Gene (395)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (289)   
   KEGG MGENES (105)   
Protein sequence (12)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (8)   
DNA sequence (9)   
   RefSeq(nuc) (9)   
Protein domain (4)   
   InterPro (4)   
All databases (420)   

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