KEGG   ENZYME: 2.3.1.306
Entry
EC 2.3.1.306                Enzyme                                 
Name
acetyl-CoA:lysine N6-acetyltransferase;
LYC1 (gene name);
lysine N6-acetyltransferase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine [RN:R00454]
Reaction(KEGG)
R00454
Substrate
acetyl-CoA [CPD:C00024];
L-lysine [CPD:C00047]
Product
CoA [CPD:C00010];
N6-acetyl-L-lysine [CPD:C02727]
Comment
The enzyme catalyses the first step of an L-lysine degradation pathway found in many fungal species. The enzyme is specific for acetyl-CoA as the acetyl donor. cf. EC 2.3.1.32, lysine N-acetyltransferase.
History
EC 2.3.1.306 created 2021
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18854  acetyl-CoA:lysine N6-acetyltransferase
Genes
YLIYALI0E05533g
Reference
1
  Authors
Schmidt, H., Bode, R., and Birnbaum , D.
  Title
Lysine degradation in Candida maltosa: occurrence of a novel enzyme, acetyl-CoA: L-lysine N-acetyltransferase.
  Journal
Arch Microbiol 150:215-218 (1988)
Reference
2  [PMID:1682209]
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Reference
3  [PMID:8257283]
  Authors
Bode R, Thurau AM, Schmidt H.
  Title
Characterization of acetyl-CoA: L-lysine N6-acetyltransferase, which catalyses the first step of carbon catabolism from lysine in Saccharomyces cerevisiae.
  Journal
Arch Microbiol 160:397-400 (1993)
DOI:10.1007/BF00252227
Reference
4  [PMID:8082161]
  Authors
Beckerich JM, Lambert M, Gaillardin C
  Title
LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast.
  Journal
Curr Genet 25:24-9 (1994)
DOI:10.1007/BF00712962
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.306
IUBMB Enzyme Nomenclature: 2.3.1.306
ExPASy - ENZYME nomenclature database: 2.3.1.306
BRENDA, the Enzyme Database: 2.3.1.306

DBGET integrated database retrieval system