KEGG   ENZYME: 2.3.1.308
Entry
EC 2.3.1.308                Enzyme                                 
Name
tubulin N-terminal N-acetyltransferase NAT9;
NAT9 (gene name);
microtubule-associated N-acetyltransferase NAT9
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:N-terminal-Met-[tubulin] Met-Nalpha-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an N-terminal-L-methionyl-[tubulin] = an N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] + CoA [RN:R12978]
Reaction(KEGG)
R12978
Substrate
acetyl-CoA [CPD:C00024];
N-terminal-L-methionyl-[tubulin] [CPD:C22490]
Product
N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] [CPD:C22491];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both alpha- and beta-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin alpha/beta heterodimer.
History
EC 2.3.1.308 created 2022
Orthology
K25762  tubulin N-terminal N-acetyltransferase
Genes
HSA26151(NAT9)
PTR454866(NAT9)
PPS100978775(NAT9)
GGO101146152(NAT9)
PON100436102(NAT9)
NLE100603978(NAT9)
HMH116483463(NAT9)
MCC699085(NAT9)
MCF102133875(NAT9)
MTHB126939244
MNI105469135(NAT9)
CSAB103243075(NAT9)
CATY105577761(NAT9)
PANU101019954(NAT9)
TGE112610090(NAT9)
MLEU105535395(NAT9)
RRO104681335(NAT9)
RBB108537347(NAT9)
TFN117066648(NAT9)
PTEH111542448(NAT9)
CANG105509948(NAT9)
CJC100387118(NAT9)
SBQ101047378(NAT9)
CIMI108309382(NAT9)
CSYR103259735(NAT9)
MMUR105878910(NAT9)
LCAT123650761(NAT9)
PCOQ105824766(NAT9)
OGA100955741(NAT9)
MMU66176(Nat9)
MCAL110304383(Nat9)
MPAH110332132(Nat9)
RNO303669(Nat9)
MCOC116076836(Nat9)
ANU117710657(Nat9)
MUN110547599(Nat9)
CGE100774051(Nat9)
MAUA101826874(Nat9)
PROB127219000(Nat9)
PLEU114707094(Nat9)
MORG121436212(Nat9)
MFOT126500359
AAMP119811820(Nat9)
NGI103732758(Nat9)
HGL101696817(Nat9)
CPOC100722236(Nat9)
CCAN109683598(Nat9)
DORD106002922(Nat9)
DSP122094973(Nat9)
PLOP125365552(Nat9)
NCAR124980879
MMMA107157808(Nat9)
OCU100356850
OPI101516449(NAT9)
TUP102468825(NAT9)
GVR103603692(NAT9)
CFA100856771(NAT9)
CLUD112672770(NAT9)
VVP112920773(NAT9)
VLG121473331(NAT9)
NPO129506910(NAT9)
AML100475320(NAT9)
UMR103665716(NAT9)
UAH113244665(NAT9)
UAR123802928(NAT9)
ELK111160320
LLV125086655
MPUF101673928(NAT9)
MNP132003364(NAT9)
MLK131816235(NAT9)
NVS122906013(NAT9)
ORO101370571(NAT9)
EJU114216202(NAT9)
ZCA113939577(NAT9)
MLX118024298(NAT9)
NSU110583376(NAT9)
LWW102736416(NAT9)
FCA101091487(NAT9)
PYU121017881(NAT9)
PCOO112864647(NAT9)
PBG122485869(NAT9)
PVIV125151587(NAT9)
LRUF124513447
PTG102965049(NAT9)
PPAD109276969
PUC125926400
AJU106987800
HHV120228215(NAT9)
BTA514377(NAT9)
BOM102280628(NAT9)
BIU109573958(NAT9)
BBUB102411645(NAT9)
BBIS105000326(NAT9)
CHX102174595(NAT9)
OAS101103166(NAT9)
BTAX128064735(NAT9)
ODA120866710(NAT9)
CCAD122434883(NAT9)
MBEZ129544749(NAT9)
SSC100359356(NAT9)
CFR102515497(NAT9)
CBAI105065680(NAT9)
CDK105104616(NAT9)
VPC102527701(NAT9)
BACU103000111(NAT9)
BMUS118886764(NAT9)
LVE103087003(NAT9)
OOR101285958(NAT9)
DLE111182863(NAT9)
PCAD102974632(NAT9)
PSIU116746439(NAT9)
NASI112410354(NAT9)
ECB100060418(NAT9)
EPZ103546548(NAT9)
EAI106830268(NAT9)
MYB102248025(NAT9)
MYD102765557(NAT9)
MMYO118671174(NAT9)
MLF102440681(NAT9)
PKL118704611(NAT9)
EFUS103298312(NAT9)
MNA107542930(NAT9)
DRO112298788(NAT9)
SHON119000950(NAT9)
AJM119065286(NAT9)
PDIC114503367(NAT9)
PHAS123817351(NAT9)
MMF118634261(NAT9)
PPAM129086696(NAT9)
HAI109383707(NAT9)
RFQ117013476(NAT9)
PALE102884405(NAT9)
PGIG120600243(NAT9)
PVP105293333(NAT9)
RAY107498097 107503800(NAT9)
MJV108386096(NAT9)
TOD119230704(NAT9)
SARA101541728(NAT9)
LAV100656812(NAT9)
TMU101340539
ETF101638799(NAT9)
DNM101441473(NAT9)
MDO100028058(NAT9)
GAS123244439(NAT9)
SHR100931763(NAT9)
AFZ127560502
PCW110219269(NAT9)
OAA100083113(NAT9)
GGA422109(NAT9)
PCOC116232380(NAT9)
MGP100539937(NAT9)
CJO107322367(NAT9)
TPAI128082978(NAT9)
LMUT125702035(NAT9)
NMEL110407192(NAT9)
APLA101795120(NAT9)
ACYG106034834(NAT9)
CATA118253854(NAT9)
AFUL116496536(NAT9)
TGU100224642(NAT9)
LSR110484343(NAT9)
SCAN103819829(NAT9)
PMOA120505698(NAT9)
OTC121338336(NAT9)
PRUF121363837(NAT9)
GFR102040669(NAT9)
FAB101818008(NAT9)
OMA130260331(NAT9)
PHI102113071(NAT9)
PMAJ107212573(NAT9)
CCAE111937338(NAT9)
CCW104694296(NAT9)
CBRC103621746(NAT9)
ETL114070600(NAT9)
ZAB102070393(NAT9)
ACHL103801929(NAT9)
SVG106854314(NAT9)
MMEA130584410(NAT9)
HRT120761018(NAT9)
FPG101916729(NAT9)
FCH102054881(NAT9)
CLV102086034(NAT9)
EGZ104125412(NAT9)
NNI104020681(NAT9)
PCRI104036731(NAT9)
PLET104623751(NAT9)
EHS104512131(NAT9)
PCAO104042291(NAT9)
ACUN113486824(NAT9)
TALA104356869(NAT9)
PADL103916693(NAT9)
AFOR103899231(NAT9)
ACHC115341002(NAT9)
HALD104318976(NAT9)
HLE104839153(NAT9)
AGEN126043916
GCL127024041
CCRI104157834(NAT9)
CSTI104563777(NAT9)
CMAC104475011(NAT9)
MUI104543793(NAT9)
BREG104640984(NAT9)
FGA104082805(NAT9)
GSTE104261408(NAT9)
LDI104342247(NAT9)
MNB103768328(NAT9)
OHA104337041(NAT9)
NNT104404244(NAT9)
SHAB115616652(NAT9)
DPUB104302377(NAT9)
PGUU104469713(NAT9)
ACAR104519049(NAT9)
CPEA104393193(NAT9)
AVIT104271952(NAT9)
CVF104281586(NAT9)
RTD128918034(NAT9)
CUCA104061939(NAT9)
TEO104375060(NAT9)
BRHI104489061(NAT9)
AAM106500034(NAT9)
AROW112977728(NAT9)
NPD112953679(NAT9)
TGT104569084(NAT9)
DNE112982535(NAT9)
SCAM104146709(NAT9)
ASN102372034(NAT9)
AMJ102562471(NAT9)
CPOO109315042(NAT9)
GGN109297778(NAT9)
PSS102457917(NAT9)
CMY102947725(NAT9)
CCAY125621752(NAT9)
DCC119842907(NAT9)
CPIC101951433(NAT9)
TST117887350(NAT9)
CABI116827508(NAT9)
MRV120383215(NAT9)
ACS100566602(nat9)
ASAO132768648(NAT9)
PVT110085798(NAT9)
SUND121921634(NAT9)
PBI103064871(NAT9)
PMUR107290916(NAT9)
CTIG120307764(NAT9)
TSR106539709(NAT9)
PGUT117660543(NAT9)
APRI131190330(NAT9)
PTEX113437116(NAT9)
NSS113412043(NAT9)
VKO123035603(NAT9)
PMUA114590576(NAT9)
PRAF128407451(NAT9)
ZVI118079800(NAT9)
HCG128342912(NAT9)
GJA107110037(NAT9)
STOW125429250(NAT9)
EMC129326868(NAT9)
XLA108701102(nat9.L) 108702799(nat9.S)
XTR100495076(nat9)
RTEM120919226(NAT9)
BBUF121003804(NAT9)
BGAR122942563(NAT9)
MUO115472183(NAT9)
GSH117367788(NAT9)
DRE326898(nat9)
SRX107722187 107755518
SANH107684049 107702469
SGH107566461 107581577
CCAR109094701 109100003
CAUA113069511 113073772 113111606
CGIB127969465 128025388
PTET122355142(nat9)
LROH127174459(nat9)
OMC131551638(nat9)
PPRM120474627(nat9)
RKG130102798(nat9)
MAMB125255484(nat9)
CIDE127523915
MASI127423336 127426908
TROS130569069(nat9)
TDW130439505(nat9)
MANU129421230(nat9)
IPU100526711
IFU128616899(nat9)
PHYP113527131(nat9)
SMEO124388940(nat9)
TFD113651624(nat9)
TVC132862584(nat9)
AMEX103023977(nat9)
CMAO118809252(nat9)
EEE113572831(nat9)
CHAR105907488(nat9)
TRU101069711(nat9)
TFS130530742(nat9)
TNGGSTEN00012903G001
LCO104923423(nat9)
NCC104946509(nat9)
TBEN117474101(nat9)
CGOB115025126(nat9)
PGEO117464902(nat9)
GACU117544604(nat9)
EMAC134870315(nat9)
ELY117247194(nat9)
EFO125880545(nat9)
PLEP121965205
SLUC116061160(nat9)
ECRA117936468(nat9)
ESP116671764(nat9)
PFLV114548213(nat9)
GAT120819731(nat9)
PPUG119212833(nat9)
AFB129091478(nat9)
CLUM117748602(nat9)
PSWI130203591(nat9)
MSAM119916178(nat9)
SCHU122867257(nat9)
CUD121528341(nat9)
ALAT119010373(nat9)
MZE101486523(nat9)
ONL100690219(nat9)
OAU116326002(nat9)
OLA101164695(nat9)
OML112154651(nat9)
CSAI133419623(nat9)
XMA102226290(nat9)
XCO114152321(nat9)
XHE116727546(nat9)
PRET103481619(nat9)
PFOR103151080(nat9)
PLAI106939019(nat9)
PMEI106928961(nat9)
GAF122822854(nat9)
PPRL129368255(nat9)
CVG107090921(nat9)
CTUL119799085(nat9)
GMU124874947(nat9)
NFU107387716(nat9)
KMR108246405(nat9)
ALIM106516667(nat9)
NWH119423756(nat9)
AOCE111587460
MCEP125022938(nat9)
CSEM103381784(nat9)
POV109640956(nat9)
SSEN122758835(nat9)
HHIP117753090(nat9)
HSP118100784(nat9)
SMAU118287608(nat9)
LCF108876329
SDU111219867(nat9)
SLAL111673538(nat9)
XGL120794333(nat9)
HCQ109516503(nat9)
SSCV125991232
SBIA133495813(nat9)
PEE133395160(nat9)
PTAO133469328(nat9)
BPEC110164395(nat9)
MALB109959351 109961957
BSPL114845822(nat9)
SJO128380905(nat9)
SASA100194599(nat9)
STRU115153484(nat9)
OTW112257506(nat9)
OMY110502755(nat9)
OGO124038449(nat9)
ONE115113002(nat9)
OKI109899909(nat9)
OKE118397979(nat9)
SALP111977886(nat9)
SNH120046681(nat9)
CCLU121575569(nat9)
ELS105007196(nat9)
SFM108940178(nat9)
PKI111848634(nat9)
AANG118221466(nat9)
LOC102688314(nat9)
PSPA121295843(nat9)
ARUT117422854(nat9)
PSEX120518193(nat9)
LCM102362144(NAT9)
CMK103175443(nat9)
RTP109917341(nat9)
CPLA122561973(nat9)
HOC132827867(nat9)
LERI129708412(nat9)
LRJ133347296(NAT9)
BFO118428898
BBEL109483311
CIN100177307
SCLV120342362
SPU115918668 586164
LPIC129272385 129272386
APLC110980907
AJC117116852
SKO102802618
DMEDmel_CG11539(Mnat9)
DER6554300
DSE6619506
DSIDsimw501_GD16381(Dsim_GD16381)
DYADyak_GE23310
DAN6505901
DSR110186253
DPO4801114
DPE6588454
DMN108156484
DWI6647946
DMODmoj_GI24198
DAZ108610551
DNV108654277
DHE111594487
DVI6629745
CCAT101448723
BOD106617410
BDR105231515
RZE108364285 108372879
AOQ129250219
TDA119680040 119681249
MDE101893670
LCQ111682402
LSQ119604055
GFS119639410
ECOE129952896
CLON129610987
HIS119660148
AGA1269804
ACOZ120948142
AARA120894718
AMER121592715
ASTE118510135 118516925
AFUN125771353
AMOU128304937
AALI118466303
AAG5569894
AALB109399231
CQUCpipJ_CPIJ019114
CPII120422650 120431519
BCOO119081123
AME551818
ACER107997645
ADR102674348
AFLR105734749
BIM112211976
BBIF117208963
BVK117233754
BVAN117160609
BPYO122569031
FVI122537809
CCAL108632381
OBB114882717
OLG117602019
MGEN117222041
NMEA116430425
SOC105204815
MPHA105838136
AEC105152261
ACEP105620345
PBAR105422285
VEM105558664
HST105191135
CFO105256403
FEX115237840
LHU105674925
PGC109856772
OBO105275544
PCF106785058
PFUC122520001
VPS122631829
VCRB124426828
VVE124952524 124952525
NVI100122277
CSOL105368510
TPRE106652313
MDL103579532
FAS105272315
DAM107036373
AGIF122849299
CINS118064024
VCAN122408531
CCIN107262896
AROA105691401
TCA659678
DPA109544902
SOY115877929
AGRG126750416
ATD109594083
CSET123321003
AGB108916235
LDC111507784
NVL108570011
APLN108743371
PPYR116180400
OTU111417406
BMOR101740766
BMAN114250347
MSEX115446980
DPLKGM_208723
BANY112043135
MJU123864820
NIQ126775701
VCD124538045
MCIX123663587
PMAC106712380
PPOT106111195
PXU106117366
PRAP110997859
PBX123717665
PNAP125061700
ZCE119829977
CCRC123704842
LSIN126966060
HAW110383743
HZE124636359
TNL113492854
SLIU111354167
OFU114355722
PGW126382302
CFEL113366350 113366351
CCRN123298424
BTAB109040758
DCI103520290
CLEC106672556
HHAL106684780
NLU111044642
HVI124353688
MQU129002170 129003852
PHUPhum_PHUM233560
FOC113207758
TPAL117644001
ZNE110834041
CSEC111869239
SGRE126356000
BROR134541146
IEL124153766
FCD110847193
DPXDAPPUDRAFT_306678
DMK116931727
DPZ124349981
PVM113807881
PJA122243168
PCHN125042747
HAME121875829
PCLA123767926
PTRU123510092
ESN126984396
HAZT108667477
EAF111702509
LSM121117316
TCF131892016
PPOI119092281
DSV119453340
RSAN119399845
RMP119180023
VDE111247405
VJA111264340
DPTE113796016
DFR124491651
CSCU111632690
PTEP107456162
ABRU129983969
UDV129225532
SDM118195410
LPOL106478449
PMEO129586318
CELCELE_Y67D2.5(Y67D2.5)
CBRCBG_11716
CRQGCK72_011626
NAINECAME_02500
BMYBM_BM7000(Bm7000)
LOALOAG_08006
HROHELRODRAFT_157613
LGILOTGIDRAFT_195719
PVUL126812395
PCAN112564492
BGT106079305
GAE121380147
HRF124110842
HRJ124291681
CRG105340332
CVN111118473
CANU128167882
OED125671227
MYI110467350
PMAX117336994
MCAF127709073
MMER123564595
RPHI132720212
DPOL127866556
OBI106882876
OSN115209791
LAK106156707
NVE5506891
EPA110238091
ATEN116291150
ADF107341579
AMIL114957649
PDAM113664274
SPIS111328312
HMG100205319
HSY130636239
TADTRIADDRAFT_20514
ATHAT2G04845
ALY9321841
CRB17891561
CSAT104698690 104747157 104766520 104767889
EUSEUTSA_v10002661mg
BRP103860317
BNA106439802 111204594
BOE106331981
RSZ108857640
THJ104826618
CPAP110824119
CIT102617341
CICCICLE_v10016673mg
PVY116126385
MINC123222444
TCC18612421
GRA105799896
GHI107952802 107954665
GAB108468064
DZI111305565 111314526
EGR104424664
GMX100817900
GSJ114380809
PVUPHAVU_006G013300g
VRA106779961
VAR108319771
VUN114186811
VUM124825332
CCAJ109817982
APRC113853803
MTR11436556
TPRA123910250
CAM101498957
PSAT127083256
VVO131639585
LJALj0g3v0001809.1(Lj0g3v0001809.1) Lj0g3v0274749.1(Lj0g3v0274749.1)
ADU107463685
AIP107644966
AHF112709668 112751959 112776169
LANG109344404
PCIN129295772 129315584 129315600
QSAO6P43_014497
FVE101314159
RCN112187035
PPER18784363
PMUM103329221
PAVI110770226
PDUL117622309
MDM103442969
MSYL126597710 126634470
PXB103955047
ZJU107416988
MNT21402948
CSAV115701155
CSV101211998
CMO103500531
BHJ120077832
MCHA111007921
CMAX111468317
CMOS111455101
CPEP111811812
RCU8275952
HBR110650408
MESC110628354
POP7455974
PEU105110228
PALZ118033253
JRE109012636
CILL122305457
CAVE132183386
QSU112018541 112040943
QLO115955599
TWL120000983
VVI100240921
VRI117927341
SLY101254389
SPEN107020740
SOT102589732
SSTN125869305
SDUL129880641
CANN107867768
LBB132640978
NTA107796380
NSY104210517 104224824
NTO104105519
NAU109208939
INI109155596
ITR115995583
SIND105178767
OEU111370203 111382391
EGT105951890
SSPL121810896
SMIL131009561
SHIS125187196
APAN127265844
HAN110895245
ECAD122596056
LSV111918692
CCAV112517218
DCR108220054
CSIN114256406
RVL131329317
AEW130751737 130789765
BVG104902795
SOE110803826
CQI110691861 110701907
ATRI130805274
MOF131149278
NNU104606573
MING122093582
TSS122639824
PSOM113336895
OSA4331926
DOSAOs03t0194400-01(Os03g0194400)
OBR102700315
OGL127768068
BDI100840353
ATS109764666
TDC119284807 119291392
TAES123084964 123093144 123098417
TUA125531131
LPER127297087
LRD124696197 124696391
SBI8054260
ZMA100217178
SITA101767593
SVS117838576
PVIR120647003 120691916
PHAI112878094
PDA103713376 120111047
EGU105056197
MUS103973431
ZOF121975142 122033905
PEQ110024496
AOF109820047
MSIN131219539
NCOL116259733
ATR18446634
SMOSELMODRAFT_108827
VCNVOLCADRAFT_56363
MNGMNEG_9268
CVRCHLNCDRAFT_20902
OLUOSTLU_7831
OTAOT_ostta04g03750
MISMICPUN_60338
MPPMICPUCDRAFT_7579(JGI:MicpuC2_7579)
GSLGasu_33900
CCPCHC_T00008016001
BBRXBRETT_001911
SPOSPBC577.03c
SOMSOMG_02269
CNECNH03620
CNBCNBI3150
CNGCNAG_05268
CGICGB_I4110C
CDEUCNBG_5694
TMSTREMEDRAFT_18845
TASAA1Q1_01935
CCACCcaHIS019_0704240(CcaverHIS019_0704240)
PPLPOSPLDRAFT_88240
TVSTRAVEDRAFT_55891
DSQDICSQDRAFT_113419
PCOPHACADRAFT_132799
SHSSTEHIDRAFT_88429
HIRHETIRDRAFT_109040
PSQPUNSTDRAFT_78124
FMEFOMMEDRAFT_167742
GTRGLOTRDRAFT_69772
RSXRhiXN_00407
LBCLACBIDRAFT_300463
CCICC1G_15149
ABPAGABI1DRAFT47168(AGABI1DRAFT_47168)
ABVAGABI2DRAFT123203(AGABI2DRAFT_123203)
PCUBJR316_0011364
MPRMPER_08010
MRRMoror_1808
MOREE1B28_006063
SCMSCHCO_014064(SCHCODRAFT_014064)
CPUTCONPUDRAFT_151165
SLASERLADRAFT_468094
WSEWALSEDRAFT_4358
WICJ056_003526
UMAUMAG_10032
PFPPFL1_00273
SGRAEX895_000161
MGLMGL_1789
MRTMRET_2025
MSYMMSY001_0912
PGRPGTG_15959
PTRCPtA15_7A492
PSTRPst134EA_013518
MLRMELLADRAFT_101377
SREPTSG_00086
DDIDDB_G0272710(nat9)
DPPDICPUDRAFT_26513
DFADFA_05686(nat9)
PTIPHATRDRAFT_34301
FCYFRACYDRAFT_195167
TPSTHAPSDRAFT_38370
AAFAURANDRAFT_15371
SPARSPRG_10361
GTTGUITHDRAFT_164154
 » show all
Reference
1  [PMID:33479178]
  Authors
Mok JW, Choi KW.
  Title
Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development.
  Journal
Proc Natl Acad Sci U S A 118:e2010140118 (2021)
DOI:10.1073/pnas.2010140118
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.308
IUBMB Enzyme Nomenclature: 2.3.1.308
ExPASy - ENZYME nomenclature database: 2.3.1.308
BRENDA, the Enzyme Database: 2.3.1.308

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