KEGG   ENZYME: 2.3.1.310
Entry
EC 2.3.1.310                Enzyme                                 
Name
benzoylsuccinyl-CoA thiolase;
bbsAB (gene names)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(S)-2-benzoylsuccinyl-CoA:CoA benzoyltransferase (benzoyl-CoA-forming)
Reaction(IUBMB)
(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA [RN:R05587]
Reaction(KEGG)
R05587
Substrate
(S)-2-benzoylsuccinyl-CoA [CPD:C09820];
CoA [CPD:C00010]
Product
benzoyl-CoA [CPD:C00512];
succinyl-CoA [CPD:C00091]
Comment
The enzyme, characterized from the bacteria Thauera aromatica and Geobacter metallireducens, participates in an anaerobic toluene degradation pathway.
History
EC 2.3.1.310 created 2022
Pathway
ec00623  Toluene degradation
Orthology
K07549  benzoylsuccinyl-CoA thiolase BbsA subunit
K07550  benzoylsuccinyl-CoA thiolase BbsB subunit
Genes
BBHBN112_0566
BBRBB2763
BBXBBS798_2593
BGVCAL12_06020
EBAc2A315(bbsB) c2A316(bbsA)
APETToN1_01600(bbsB) ToN1_01610(bbsA)
AZIAzCIB_4525 AzCIB_4526
AZDCDA09_07420 CDA09_07425 CDA09_21990 CDA09_21995
TCLTchl_1385 Tchl_1386
TAKTharo_3089 Tharo_3090
GMEGmet_1528(bbsA) Gmet_1529(bbsB)
GEOGeob_2427(bbsA) Geob_2428(bbsB)
DTOTOL2_C01480(bbsB) TOL2_C04900(bhsA)
DOVDSCO28_65760
DWDDSCW_52910
DMMdnm_089750(bhsA) dnm_089760(bhsB)
DGIDesgi_0641 Desgi_0642
MBRDMBRA_56580
SCADDN051_35635
IAMHC251_19970
HDOMUK72_17285
 » show all
Reference
1  [PMID:10629170]
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence
Reference
2  [PMID:35313080]
  Authors
Weidenweber S, Schuhle K, Lippert ML, Mock J, Seubert A, Demmer U, Ermler U, Heider J.
  Title
Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
  Journal
FEBS J 289:5599-5616 (2022)
DOI:10.1111/febs.16443
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.310
IUBMB Enzyme Nomenclature: 2.3.1.310
ExPASy - ENZYME nomenclature database: 2.3.1.310
BRENDA, the Enzyme Database: 2.3.1.310

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