KEGG ENZYME: 2.3.1.80

ENZYME: 2.3.1.80

Entry

EC 2.3.1.80                 Enzyme

Name

cysteine-S-conjugate N-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:S-substituted L-cysteine N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate [RN:R04950]

Reaction(KEGG)

R04950

Substrate

acetyl-CoA [CPD:C00024];
L-cysteine-S-conjugate [CPD:C02882]

Product

CoA [CPD:C00010];
N-acetyl-L-cysteine-S-conjugate

Comment

S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors.

History

EC 2.3.1.80 created 1984

Pathway

ec00480

Glutathione metabolism

ec01100

Metabolic pathways

Orthology

K20838

N-acetyltransferase 8

Genes

HSA:	9027(NAT8)

PTR:	470406(NAT8) 739241(NAT8B)

PPS:	100967484(NAT8) 100971190

GGO:	101133830 109025735(NAT8)

PON:	100173062(NAT8) 100435458 100436198

NLE:	100606331 100606676

HMH:	116484090(NAT8)

MCC:	706820(NAT8)

MCF:	102119614(NAT8)

MTHB:

126934068

MNI:	105465271(NAT8)

CSAB:

103220050

CATY:

105576587

PANU:

101009924(NAT8)

TGE:	112604608(NAT8)

MLEU:

105540169

RRO:	104661367(NAT8)

RBB:	108532437(NAT8)

TFN:	117062027(NAT8)

PTEH:

111550503(NAT8)

CANG:

105514053

CJC:	100394433 100407076

SBQ:	101032039(NAT8)

CIMI:

108299588 108299596

CSYR:

103270032(NAT8)

MMUR:

105866750 105884612

LCAT:

123637054(NAT8) 123637055

PCOQ:

105812074 105821475

OGA:	100948530 100949350 111721719

MMU:	100043497(Nat8f7) 100504710(Nat8f6) 66116(Nat8f1) 68396(Nat8) 69049(Nat8f5) 93673(Nat8f2) 93674(Nat8f3)

MCAL:

110296074 110296552 110296554 110296685 110296691

MPAH:

110316573 110316574(Nat8) 110317018 110317030 110317113 110317171

RNO:	102549803(Nat8f4) 113892(Nat8f3) 114020(Nat8f5) 500237(Nat8f2) 59300(Nat8f1) 64570(Nat8)

MCOC:

116098219(Nat8) 116098220 116098221 116099166 116099167 116099169 116099949

ANU:	117715170 117715418 117715419 117715420 117715455 117715464

MUN:	110547154 110547165 110547168 110547169 110547171 110547186

CGE:	100767690 100767982 100771416 100771708 113837001 113837005 113837015 113837953

MAUA:

101829072 101829335 101829882 101835612 101837324 121136634 121136636

PROB:

127235527(Nat8) 127235534 127235540 127235552 127235568

PLEU:

114685558 114685560 114688544 114688545 114688549 114688551

MORG:

121435510 121435534 121440077 121441282 121441537 121465738

MFOT:

126496580 126515321 126515323 126515325 126515328 126515331

AAMP:

119806382 119806383 119806384 119808025 119808026 119808027

NGI:	103749950(Nat8b)

HGL:

101720890

CPOC:

100714111 100714389 100714665 100714943 100715229

CCAN:

109679392 109679393 109692614 109699979 109702888 109702890 109702891

DORD:

106000492 106000493 106000497 106000498 106000499 106000512

DSP:	122125133 122125135 122125153 122125159

PLOP:

125355966 125356342 125356343 125356345

NCAR:

124962937 124962938 124962939 124962940 124963647

MMMA:

107134923 107134924 107135121 107136962 107137080 107137081 107137165 107137168

OCU:	100352648 100352904

OPI:	101516522(NAT8)

TUP:	102482811(NAT8)

GVR:

103589248

CFA:	100856478(NAT8)

CLUD:

112664220(NAT8)

VVP:	112916821(NAT8)

VLG:	121491024(NAT8)

NPO:	129501450(NAT8)

AML:	100481005(NAT8)

UMR:	103671389(NAT8)

UAH:	113243903(NAT8)

UAR:	123786058(NAT8)

ELK:

111148203

LLV:

125109058

MPUF:

101692477(NAT8B)

MNP:	132022508(NAT8)

MLK:	131808059(NAT8)

NVS:	122914989(NAT8)

ORO:	101363205(NAT8B)

EJU:	114218970(NAT8)

ZCA:	113937264(NAT8)

MLX:	118007970(NAT8)

NSU:	110588834(NAT8)

LWW:	102725855(NAT8)

FCA:	101098621(NAT8)

PYU:	121019250(NAT8)

PCOO:

112869680(NAT8)

PBG:	122497015(NAT8)

PVIV:

125163015(NAT8)

LRUF:

124503932

PTG:	102957307(NAT8B)

PPAD:

109262891(NAT8)

PUC:

125936331

AJU:

106967787

HHV:	120237022(NAT8)

BTA:	101902604(NAT8)

BOM:	102278525(NAT8)

BIU:	109565932(NAT8)

BBUB:

102392037(NAT8)

BBIS:

104980907

CHX:	102181787(NAT8)

OAS:	101104899(NAT8)

BTAX:

128056835(NAT8)

ODA:	120851256(NAT8)

CCAD:

122441406(NAT8)

MBEZ:

129540078(NAT8)

SSC:	100516363(NAT8)

CFR:	102507921(NAT8) 116669040

CBAI:

105078088 105082464

CDK:	105085749 116157529

VPC:	102532352(NAT8)

BACU:

103001786(NAT8) 103011589(NAT8B)

BMUS:

118905692(NAT8)

OOR:

101283003

DLE:	111167883(NAT8)

PCAD:

112067510(NAT8)

PSIU:

116764085(NAT8)

NASI:

112412336(NAT8)

ECB:	100058571 100058847

EPZ:

103542782

EAI:	106828286 106828287(NAT8)

MYB:	102238886(NAT8B) 102258540 102264232(NAT8)

MYD:	102759258 102760011 102772700

MMYO:

118668852(TPRKB) 118668853 118674545

MLF:	102421789 102426829

PKL:	118717542 118717543

EFUS:

103284800 129147002 129147003

MNA:	107529202 107529203 107537368

DRO:	112303117(NAT8)

SHON:

118988517(NAT8)

AJM:	119038406(NAT8)

PDIC:

114500389(NAT8) 114500391

PHAS:

123811987(NAT8)

MMF:	118630912(NAT8)

PPAM:

129086796(NAT8)

HAI:	109371189 109371193

RFQ:	117032749(NAT8)

PALE:

102895046 102895288 102896662

PGIG:

120594618(NAT8) 120611045

PVP:	105290779(NAT8) 105311326

RAY:

107502947

MJV:	108389752(NAT8)

TOD:	119238577 119259071 119259860

SARA:

101550682 101550950

SETR:

126024112 126024662

LAV:	100669016 100669295 100669579

TMU:

101353867

ETF:	101654648(NAT8)

MDO:	100021822 100022265 100022287 100022311 100022341 100022462 100027946 103094600

GAS:	123233125 123234509 123234510 123234514 123234515 123242189 123251307

SHR:	100927631 100933401 100935099 105749210(NAT8)

AFZ:	127539996 127547363 127547368 127547369 127553357

PCW:	110218372 110218391 110218393(NAT8) 110218423 110221068 110223576

OAA:	100076893(NAT8) 100083900 100086348 100091934 114805410

GGA:	107056278 429762(NAT8) 776932(NAT8B)

PCOC:

116225638 116225639 116241588

MGP:

104916712

CJO:	107306852 107306853 107306860

TPAI:

128072965 128072966

LMUT:

125691849 125691850

NMEL:

110390949 110390950 110390953

ACYG:

125180668 125180669

CATA:

118260592 118260593

TGU:	115494848(NAT8)

LSR:	110469863(NAT8)

PMOA:

120509254(NAT8)

OTC:	121335083(NAT8)

PRUF:

121356940(NAT8)

OMA:	130252111(NAT8)

PHI:

102103115

PMAJ:

107199384(NAT8)

ETL:

114070483

SVG:

106853121

MMEA:

130586300(NAT8)

HRT:	120748361(NAT8)

FPG:	101923652 101923830

FCH:	102052756 102052929

CLV:

110365702

NNI:	104011623 104011626

AFOR:

103905799(NAT8)

ACHC:

115338093 115338094

HLE:	104832357 104832358

AGEN:

126051712 126051723

SHAB:

115610597 115610598

DPUB:

104308800

RTD:	128910087(NAT8)

TEO:

104382294

AAM:

106485319

ASN:	102374866 102375188

AMJ:	102570938 102572312

PSS:	102454462 102460069

CMY:	102930433 102947988(NAT8)

CCAY:

125635184

DCC:	119854481 119855204 119855702

CPIC:

101931009 101931016 101932235 101935729 101935906 101940281 101941653 101944101 101946392 101946587 101953511 101953710

TST:	117870377 117870378

CABI:

116829277(NAT8) 116829278

MRV:	120406350 120406354 120406356 120406357

ACS:	100565860 100566062 103281262

ASAO:

132777116 132777117 132777118

PVT:	110086606 110086612 110086613

SUND:

121931876(NAT8) 121931877

PBI:	103050100 103053349

PMUR:

107287842 107287863

CTIG:

120319721 120319726

TSR:	106545778 106555384

APRI:

131203028(NAT8)

PTEX:

113452539 113452862 113453793 113453794

NSS:	113427796 113427798 113432297 113432306

VKO:	123022809 123023014 123023015

PMUA:

114604315 114604606(NAT8)

PRAF:

128420536(NAT8) 128420537

ZVI:	118077537 118077548

HCG:	128326397 128328322 128328458

GJA:	107115846 107125475

STOW:

125440179 125440180 125440181

EMC:	129336464 129336803

XLA:	108696285(nat8.1.L) 108696290(nat8.2.L) 108697419(nat8.5.L) 108705738(nat8.7.S) 108719400(nat8.3.L) 108719408(nat8.6.L) 373623(nat8.6.S) 414583(nat8.1.S)

XTR:	100124951(nat8.1) 100145252(nat8.7) 100489204(nat8.2) 100489358(nat8.3) 100489520(nat8.5) 100489681 100489847(nat8.9) 101731538(nat8.6) 493291(nat8.4)

NPR:	108796050 108796051 108796057 108796941 108796942 108796943 108796955 108796956 108798959 108798962 108798963

RTEM:

120917942 120924304 120924316 120924336 120924478 120924504 120924516 120924523 120924575 120924588 120924605 120924614 120924770 120924771 120924772 120924774 120924775 120924776

BBUF:

120982821 120982822 120990545 120990548 120990549 120990551 120991106 120991107 120991854 120991855 120991858 120991859 120991860

BGAR:

122924386 122933993 122934015 122934025 122934036 122934054 122934069 122934080 122934093 122934128

MUO:	115461243 115461244

GSH:	117364626 117364633 117364641

DRE:	100002956(si:ch211-195e19.1) 100004652(nat8l2)

SRX:	107733671 107733716 107744405 107747598 107758781

SANH:

107664162 107666411 107666562 107667058 107696411

SGH:	107560502 107562255 107580815 107585290 107587650 107587914

CCAR:

109048520 109057670 109069999 109070000 109084742 109086990 109087021

CAUA:

113051076 113051077 113057103 113065360 113076083 113078344 113078346 113112814

CGIB:

127969742 128016029 128016031 128026325

PTET:

122346403(nat8l2) 122357046(nat8)

LROH:

127166426 127166427 127174762(nat8)

OMC:	131542460(nat8l2) 131552183(nat8)

PPRM:

120479462(nat8) 120493384(nat8l2)

RKG:	130102893(nat8) 130104156(nat8l2)

MAMB:

125273353(nat8l2) 125276750 125276751(nat8)

CIDE:

127514897 127525391

MASI:

127412326 127413960 127446027

TROS:

130557061(nat8l2) 130558944(nat8)

TDW:	130424850(nat8l2) 130424911 130431797(nat8)

MANU:

129415900(nat8) 129449884 129450637 129450638 129450639 129450878

IPU:	100528621(cmlo) 108271756(nat8l2)

IFU:	128605446 128614909(nat8l2)

PHYP:

113537203 113543984

SMEO:

124377245(nat8) 124393567(nat8l2) 124401823

TFD:	113642683(nat8l2) 113644995(nat8)

TVC:	132843975(nat8l2) 132847157(nat8)

AMEX:

103027576 103035650 103037014 103037654 103041541 111193667 111193668

CMAO:

118807572 118807639 118808507 118810247 118810251

EEE:	113571638 113585848 113585855

CHAR:

105899616(nat8) 105906356 105907821(nat8l2)

TRU:	101061992 101068639 101071337(nat8) 101077733 105418616

TFS:	130513325(nat8) 130524397 130524398 130524400 130524401 130524402 130530099

TNG:	GSTEN00038389G001

LCO:	104923878 104932474(nat8) 104935383

NCC:	104950447 104952185 104952196 104962577

TBEN:

117483385 117489794(nat8l2) 117493881 117493886

CGOB:

115007748 115011241 115027023(nat8)

PGEO:

117446249 117449210 117467512 117468201

GACU:

117537344 117539573(nat8l2) 117550054 117558812 117558814

EMAC:

134870815 134881574 134881575 134882414(nat8l2)

ELY:	117256715 117257323 117257433 117258832 117266763

EFO:	125880609 125891875 125900880

PLEP:

121946499 121950294 121955196 121955213 121963702(nat8)

SLUC:

116043752 116051432 116057583(nat8) 118492926

ECRA:

117935776(nat8) 117943980 117943982 117948297

ESP:	116686114(nat8) 116688076 116688079 116693066

PFLV:

114546333(nat8) 114554526 114554838

GAT:	120828685 120833091(nat8) 120835658(nat8l2)

PPUG:

119194184(nat8l2) 119222708 119227272

AFB:	129100419 129103849 129106273(nat8l2)

CLUM:

117725244(nat8) 117731303(nat8l2) 117733147

PSWI:

130200075 130201828(nat8) 130208941(nat8l2)

MSAM:

119886117(nat8l2) 119905082 119910379

SCHU:

122861852(nat8) 122883485 122884840(nat8l2)

CUD:	121517538 121525780 121525781 121528410(nat8l2)

ALAT:

119005023(nat8) 119020938 119020941 119020942 119022272

MZE:	101465996(nat8) 101475129 101486240 106676491 112429980 112429981 112434796 112434827 112434830

ONL:	100691576 100693555 100694594(nat8) 100703402 109202228 109202229

OAU:	116315189(nat8) 116319325 116319467 116319474 116321972

OLA:	101159785 101160033 101160718 101173140 101173383 101173914

OML:	112145217 112145245 112145690(nat8l2) 112159627

CSAI:

133449288(nat8l2) 133456241 133462069 133462399

XMA:	102216856 102222280 102225553 102228442

XCO:	114133745 114134804 114134960 114140321

XHE:	116708613 116708614 116719670

PRET:

103458191 103458195 103464674 103467845

PFOR:

103134572 103150063 103150064 103150962

PLAI:

106952056 106952057 106960248 106962796

PMEI:

106912905 106919286 106919301 106932893

GAF:	122833041 122834765(nat8l2) 122846155 122846157

PPRL:

129372782(nat8l2) 129377192 129377367 129377445

CVG:	107083706 107096798 107096799 107097103

CTUL:

119777220 119779708 119779709 119788653(nat8l2)

GMU:	124855153(nat8) 124855633 124875078

NFU:	107385408 107390441 107391881 107391882

KMR:	108229320(nat8) 108237615

ALIM:

106527420 106536673 106536674 106536675

NWH:	119416705 119427278(nat8)

AOCE:

111566213 111578760 111578761 111579626 111579628

MCEP:

124998381 125007415(nat8l2) 125023178(nat8)

CSEM:

103381413 103381421 103385248 103386735

POV:	109635574 109636400 109640482

SSEN:

122767715(nat8l2) 122777586 122783219(nat8)

HHIP:

117756335(nat8) 117761448(nat8l2) 117764580

HSP:	118105071(nat8l2) 118111282 118116809

SMAU:

118285828 118316822

LCF:	108873565(nat8l2) 108876605 108892940

SDU:	111225478 111233597 111234875

SLAL:

111644242 111660675 111672808(nat8)

XGL:	120783050(nat8l2) 120795010 120804435

HCQ:	109513340 109528151

SSCV:

125981287 125989035

SBIA:

133495288 133513128

PEE:	133412346 133413418

PTAO:

133474620 133487378

BPEC:

110154604 110157443 110171160 110171190

MALB:

109962441(nat8) 109970779 109971435

BSPL:

114848064(nat8) 114856116(nat8l2) 114859234

SJO:	128354909(nat8l2) 128357229 128375256

SASA:

106567325 106572644 106583684 106591868 106607815

STRU:

115150085 115161846(nat8) 115168810 115173041

OTW:	112221405 112226697(nat8) 112255536(nat8l2) 112256967 121846867

OMY:	110492903 110498316(nat8) 110505940 110528564(nat8l2)

OGO:	124001187 124018552(nat8l2) 124045143 124046829(nat8)

ONE:	115101688 115120942

OKI:	109869680 109885472 109885473(nat8) 109890304

OKE:	118359487 118373225(nat8l2) 118376168 118402427

SALP:

111970525 111977091 112074940

SNH:	120023112 120060110 120061125 120064658(nat8l2)

CCLU:

121544218 121545290 121546734 121577965(nat8l2)

ELS:	105013642 105015843(nat8) 105016676

SFM:	108930887 108935794 108936586

PKI:	111835899 111845766 111845802 111845803 111853952

AANG:

118210912 118227525 118231241

LOC:

102685310

PSPA:

121294220 121302749

ARUT:

117408398 117420953 117421097

PSEX:

120527924(nat8) 120528651

LCM:	102349209 102349485 102349767 102351352 102360089

RTP:	109916921 109919252

CPLA:

122546044 122546618(nat8)

HOC:	132813312 132813314 132820068(nat8) 132824846

LERI:

129694188 129715937 129716276

LRJ:

133348929

BFO:	118417186 118419854 118427483

BBEL:

109464417 109471269 109473416 109473417

SCLV:

120339126

SKO:	102801948 102804750 102807544

LDC:

111513548

PJA:	122251805 122261856

HAME:

121865169

MNZ:

135224208

HAZT:

108672794

EAF:

111714301

LSM:

121119190

TCF:

131892700

BGT:

106072930

HRF:

124136965

OBI:

106868182

LAK:	106159074 106159075 106159098 106174736 112042394

NVE:	5507724 5507725

EPA:

110234338

ATEN:

116293235 116307908 116307913

ADF:

107355193

AMIL:

114947431 114968931

PDAM:

113664653 113673068 113673069 113673081 113673086 113673088 113677701 113677707

SPIS:

111333733 111333875 111333876 111333883 111333889 111333899 111337850 111346407

LBC:	LACBIDRAFT_293252 LACBIDRAFT_315392

CCI:	CC1G_12505

MRR:	Moror_15052

E1B28_005684 E1B28_005685 E1B28_005701 E1B28_006773 E1B28_009367

ACAN:

ACA1_044750

TET:	TTHERM_00304180

PSOJ:

PHYSODRAFT_375526

» show all

Reference

1 [PMID:6892478]

Authors

Duffel MW, Jakoby WB.

Title

Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes.

Journal

Mol Pharmacol 21:444-8 (1982)

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.80

IUBMB Enzyme Nomenclature:

2.3.1.80

ExPASy - ENZYME nomenclature database:

2.3.1.80

BRENDA, the Enzyme Database:

2.3.1.80

CAS:	81725-80-6

DBGET integrated database retrieval system