Entry
Name
ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase;
btrH (gene name)
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
Reaction(IUBMB)
4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + ribostamycin = gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein [RN:
R08909 ]
Reaction(KEGG)
Substrate
4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein];
ribostamycin [CPD:
C01759 ]
Product
gamma-L-glutamyl-butirosin B [CPD:
C18005 ];
BtrI acyl-carrier protein
Comment
The enzyme attaches the side chain of the aminoglycoside antibiotics of the butirosin family. The side chain confers resistance against several aminoglycoside-modifying enzymes.
History
EC 2.3.2.19 created 2012
Pathway
ec00524 Neomycin, kanamycin and gentamicin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13563 ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
Reference
Authors
Llewellyn NM, Li Y, Spencer JB
Title
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.19
ExPASy - ENZYME nomenclature database: 2.3.2.19