Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy

L-leucyl-tRNALeu:[protein] N-terminal L-glutamate/L-aspartate leucyltransferase

(1) L-leucyl-tRNALeu + N-terminal L-glutamyl-[protein] = tRNALeu + N-terminal L-leucyl-L-glutamyl-[protein] [RN:R11547];
(2) L-leucyl-tRNALeu + N-terminal L-aspartyl-[protein] = tRNALeu + N-terminal L-leucyl-L-aspartyl-[protein] [RN:R11548]

R11547 R11548
Reaction

L-leucyl-tRNA(Leu) [CPD:C02047];
N-terminal L-glutamyl-[protein] [CPD:C21456];
N-terminal L-aspartyl-[protein] [CPD:C21458]

The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. cf. EC 2.3.2.6, lysine/arginine leucyltransferase, and EC 2.3.2.8, arginyltransferase.

EC 2.3.2.29 created 2016