KEGG   ENZYME: 2.3.2.36
Entry
EC 2.3.2.36                 Enzyme                                 
Name
RING-type E3 ubiquitin transferase (cysteine targeting);
RING E3 ligase (misleading)
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (thioester bond-froming; RING-type)
Reaction(IUBMB)
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine
Substrate
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine;
[acceptor protein]-L-cysteine
Product
[E2 ubiquitin-conjugating enzyme]-L-cysteine;
[acceptor protein]-S-ubiquitinyl-L-cysteine
Comment
This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins. Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine48 in the pre-attached ubiquitin [2].
History
EC 2.3.2.36 created 2020
Orthology
K10636  E3 ubiquitin-protein ligase AMFR
K21665  KSHV E3 ubiquitin-protein ligase MIR1
K21666  KSHV E3 ubiquitin-protein ligase MIR2
K26515  Rhadinovirus E3 ubiquitin-protein ligase MIR1
Genes
HSA267(AMFR)
PTR735643(AMFR)
PPS100990878(AMFR)
GGO101132775(AMFR)
PON100461567(AMFR)
NLE100601377(AMFR)
HMH116471266(AMFR)
MCC699972(AMFR)
MCF101865016(AMFR)
MTHB126943827
MNI105494067(AMFR)
CSAB103233021(AMFR)
CATY105589581(AMFR)
PANU101019748(AMFR)
TGE112614262(AMFR)
MLEU105533437(AMFR)
RRO104664018(AMFR)
RBB108533840(AMFR)
TFN117087808(AMFR)
PTEH111541261(AMFR)
CANG105525407(AMFR)
CJC100392285(AMFR) 100401238
SBQ101049763(AMFR)
CIMI108285466(AMFR)
CSYR103253158(AMFR)
MMUR105866540(AMFR)
LCAT123625312(AMFR)
PCOQ105820873(AMFR)
OGA100962272(AMFR)
MMU23802(Amfr)
MCAL110299792(Amfr)
MPAH110337329(Amfr)
RNO361367(Amfr)
MCOC116069886(Amfr)
ANU117723027(Amfr)
MUN110561149(Amfr)
CGE100762626(Amfr)
MAUA101823213(Amfr)
PROB127230015(Amfr)
PLEU114694516(Amfr)
MORG121446773(Amfr)
MFOT126502957
AAMP119801914(Amfr)
NGI103749857(Amfr)
HGL101722534(Amfr)
CPOC100729655(Amfr)
CCAN109700415(Amfr)
DORD105994458(Amfr)
DSP122116327(Amfr)
PLOP125358435(Amfr)
NCAR124967519
MMMA107144673(Amfr)
OCU100342533
OPI101522119(AMFR)
TUP102484291(AMFR)
GVR103590971(AMFR)
CFA487269(AMFR)
CLUD112660148(AMFR)
VVP112929626(AMFR)
VLG121496665(AMFR)
NPO129513695(AMFR)
AML100476438(AMFR)
UMR103673897(AMFR)
UAH113252255(AMFR)
UAR123798420(AMFR)
ELK111157345
LLV125089127
MPUF101672768(AMFR)
MNP132006191(AMFR)
MLK131818464(AMFR)
NVS122911434(AMFR)
ORO101376014(AMFR)
EJU114200876(AMFR)
ZCA113936434(AMFR)
MLX118023769(AMFR)
NSU110594276(AMFR)
LWW102736217(AMFR)
FCA101091066(AMFR)
PYU121045328(AMFR)
PCOO112857373(AMFR)
PBG122494225(AMFR)
LRUF124511324
PTG102959972(AMFR)
PPAD109270896(AMFR)
PUC125915949
AJU106973285
HHV120232145(AMFR)
BTA507541(AMFR)
BOM102269565(AMFR)
BIU109572524(AMFR)
BBUB102395936(AMFR)
BBIS105004323(AMFR)
CHX102186621(AMFR)
OAS101119154(AMFR)
BTAX128063110(AMFR)
ODA120873205(AMFR)
CCAD122420089(AMFR)
MBEZ129547087(AMFR)
SSC100516197(AMFR)
CFR102504118(AMFR)
CBAI105078711(AMFR)
CDK105096166(AMFR)
VPC102532565(AMFR)
BACU103011971(AMFR)
LVE103068455(AMFR)
OOR101285163(AMFR)
DLE111165309(AMFR)
PCAD102976214(AMFR)
PSIU116744138(AMFR)
NASI112403767(AMFR)
ECB100061759(AMFR)
EPZ103564206(AMFR)
EAI106822213(AMFR)
MYB102263078(AMFR)
MYD102768348(AMFR)
MMYO118674452(AMFR)
MLF102438292(AMFR)
MNA107543368(AMFR)
PKL118720474(AMFR)
EFUS103295847(AMFR)
HAI109395629(AMFR)
DRO112296670(AMFR)
SHON118983963(AMFR)
AJM119046436(AMFR)
PDIC114488124(AMFR)
PHAS123805888(AMFR)
MMF118638422(AMFR)
RFQ117034900(AMFR)
PPAM129068223(AMFR)
PALE102885237(AMFR)
PGIG120617300(AMFR)
PVP105292073(AMFR)
RAY107499658(AMFR)
MJV108408791(AMFR)
TOD119249226(AMFR)
SARA101539387(AMFR)
LAV100672928(AMFR)
TMU101357354
ETF101659835(AMFR)
DNM101427401(AMFR)
MDO100015225(AMFR)
GAS123233652(AMFR)
SHR100919642(AMFR)
AFZ127550728
PCW110193655(AMFR)
OAA100074448(AMFR)
GGA415697(AMFR)
PCOC116243581(AMFR)
MGP100544038(AMFR)
CJO107319168(AMFR)
TPAI128081733(AMFR)
LMUT125699069(AMFR)
NMEL110404071(AMFR)
APLA101791624(AMFR)
ACYG106043119(AMFR)
CATA118246619(AMFR)
AFUL116493914(AMFR)
TGU100229415(AMFR)
LSR110473006(AMFR)
SCAN103816656(AMFR)
PMOA120507922(AMFR)
OTC121333822(AMFR)
PRUF121348781(AMFR)
GFR102042966(AMFR)
FAB101808550(AMFR)
OMA130257661(AMFR)
PHI102101410(AMFR)
PMAJ107209801(AMFR)
CCAE111934546(AMFR)
CCW104687500(AMFR)
CBRC103620166(AMFR)
ETL114070900(AMFR)
ZAB102074298(AMFR)
ACHL103797350(AMFR)
SVG106855851(AMFR)
MMEA130572702(AMFR)
HRT120757720(AMFR)
FPG101910285(AMFR)
FCH102048443(AMFR)
CLV102089865(AMFR)
EGZ104130231(AMFR)
NNI104016377(AMFR)
PCRI104024460(AMFR)
PLET104626415(AMFR)
EHS104510977
PCAO104043774(AMFR)
ACUN113484309(AMFR)
TALA104366746(AMFR)
PADL103914205(AMFR)
AFOR103896845(AMFR)
ACHC115345741(AMFR)
HALD104316995(AMFR)
HLE104842216(AMFR)
AGEN126040285
GCL127021012
CCRI104163180(AMFR)
CMAC104484763(AMFR)
MUI104536412(AMFR)
BREG104637526(AMFR)
FGA104069616(AMFR)
GSTE104254960(AMFR)
LDI104339888(AMFR)
MNB103770248(AMFR)
OHA104334764(AMFR)
NNT104407454(AMFR)
SHAB115618943 115619861(AMFR)
DPUB104299011(AMFR)
PGUU104461374(AMFR)
CPEA104386316(AMFR)
AVIT104276709
CVF104290354(AMFR)
RTD128908559(AMFR)
CUCA104055939(AMFR)
TEO104369845(AMFR)
BRHI104489432(AMFR)
AAM106490071(AMFR)
AROW112973911(AMFR)
NPD112943241(AMFR)
TGT104575140(AMFR)
DNE112990423(AMFR)
SCAM104146285(AMFR)
ASN102386411(AMFR)
AMJ102562459(AMFR)
CPOO109310474(AMFR)
GGN109289651(AMFR)
PSS102448974(AMFR)
CMY102938942(AMFR)
CCAY125620850(AMFR)
DCC119841210(AMFR)
CPIC101939044(AMFR)
TST117886476(AMFR)
CABI116827903(AMFR)
MRV120384512(AMFR)
ACS100561595(amfr)
ASAO132782865(AMFR)
PVT110085701(AMFR)
SUND121914527(AMFR)
PBI103067391(AMFR)
PMUR107296064(AMFR)
CTIG120312709(AMFR)
TSR106547928(AMFR)
PGUT117670322(AMFR)
APRI131184079(AMFR)
PTEX113445277(AMFR)
NSS113414952(AMFR)
VKO123025397(AMFR)
PMUA114601899(AMFR)
PRAF128419115(AMFR)
ZVI118086497(AMFR)
HCG128334449(AMFR)
GJA107118976(AMFR)
STOW125443550(AMFR)
EMC129344004(AMFR)
XLA398777(amfr.L) 443813(amfr.S)
XTR549837(amfr)
NPR108793917(AMFR)
RTEM120917680(AMFR)
BBUF120979995(AMFR)
BGAR122920454(AMFR)
MUO115470492(AMFR)
GSH117358835(AMFR)
DRE406442(amfra)
SRX107723982 107752457
SANH107659867 107679970
SGH107555700 107566269
CCAR109053324(amfr) 109055263
CAUA113043636 113067267
CGIB127947128 128014355
PTET122330795(amfra)
LROH127156560(amfra)
OMC131534299(amfra)
PPRM120468035(amfra)
RKG130080386(amfra)
MAMB125247412(amfra)
CIDE127507857
MASI127436293 127437456
TROS130551286(amfra)
TDW130414257(amfra)
MANU129433745(amfra)
IPU108274983(amfra)
IFU128617877(amfra)
PHYP113529910(amfr)
SMEO124392624(amfra)
TFD113660107(amfra)
TVC132856740(amfra)
AMEX103032357(amfr)
CMAO118811621(amfra)
EEE113573144(amfr)
CHAR105908732(amfra) 122130733
TRU101064558(amfr)
TFS130521548
TNGGSTEN00021431G001
LCO104919024(amfr) 104927033
NCC104942184(amfr)
TBEN117471347
CGOB115005512(amfr)
PGEO117439963
GACU117556707
ELY117256599 117262907
EFO125888016(amfra) 125902857
PLEP121960035
SLUC116060499
ECRA117943580
ESP116692584 116706973
PFLV114557764(amfr)
GAT120832411
PPUG119227701
AFB129104561
CLUM117749043
MSAM119889875 119890012
SCHU122873584 122874445
CUD121510057 121515438
ALAT119018733
MZE101467025(amfr)
ONL100699077(amfr)
OAU116314684
OLA101164292(amfr)
OML112160820
XMA102218515(amfr)
XCO114143074(amfr)
XHE116718588(amfr)
PRET103462594(amfr)
PFOR103142810(amfr)
PLAI106945602(amfr)
PMEI106906596(amfr)
GAF122825123
PPRL129364308
CVG107082783(amfr)
CTUL119780836
GMU124867326
NFU107381890(amfr)
KMR108237415
ALIM106514983(amfr)
NWH119430098
AOCE111570134(amfr)
MCEP125004907
CSEM103379358(amfr)
POV109625027(amfr)
SSEN122772698(amfra)
HHIP117758314 117763829(amfra)
HSP118109641(amfra) 118118914
LCF108872668(amfra) 108876996
SDU111218000 111236032
SLAL111653408 111659140
XGL120793226(amfra) 120794329
HCQ109528749(amfr)
SSCV125967591
SBIA133498059
PEE133397188
PTAO133474268
BPEC110175222(amfr)
MALB109954563(amfr)
BSPL114852166 114857283(amfra)
SJO128358405
SASA100380762(amfr2) 106561518 106587607
STRU115167011 115197506 115203315
OTW112218820(amfra) 112236509 112249365
OMY110499174(amfra) 110506753 110526619
OGO124033566 124033864(amfra) 124035544
ONE115113777 115113785 115134000
OKI109867334 109878792 109880635
OKE118360839 118394198 118395917(amfra)
SALP111962687 112069876 112073611
SNH120024877 120048298 120066324(amfra)
CCLU121532152 121580324(amfrb)
ELS105022624
SFM108926184 108928314
PKI111832691(amfr) 111858177
AANG118215281 118227698
LOC102687391(amfr)
PSPA121296337 121325796
ARUT117424704 117425755
PSEX120535230
LCM102364204(AMFR)
CMK103185900(amfra)
RTP109931938(amfr)
CPLA122558563(amfra)
HOC132824013(amfra)
LERI129705201(amfra)
PMRN116954093(AMFR)
LRJ133355764(AMFR)
BFO118418408
BBEL109473736
CIN100182897
SCLV120346200
SPU587600
LPIC129282475
APLC110974804
AJC117111238
SKO100372522
HIS119647974
AGA4576491
ACOZ120948260
AARA120908713
AMER121591899
ASTE118512156
AFUN125771439
AMOU128303646
AALI118466834
AAG5567142
AALB109410035 109419658 115265349
CQUCpipJ_CPIJ015192 CpipJ_CPIJ016042 CpipJ_CPIJ016043
CPII120425971
CNS116337628
BCOO119078387 119082153
AME100576187
ACER108001958
ALAB122714452
ADR102673227
AFLR100870746
BIM100743716
BBIF117217092
BVK117236421
BVAN117154560
BTER100647877
BAFF126925572
BPYO122576452
BPAS132914831
FVI122530550
CCAL108623657
OBB114879730
OLG117608849
MGEN117222384
NMEA116426163
CGIG122402210
SOC105201276
MPHA105830731
AEC105151881
ACEP105617620
PBAR105430331
VEM105559120
HST105185151
DQU106742521
CFO105254809
FEX115233965
LHU105676500
PGC109853475
OBO105278403
PCF106792729
PFUC122514120
VPS122634944
VCRB124430500
VVE124954150
LHT122499107
LBD127291268
MDL103570380
CGLO123259575
FAS105266287
DAM107036029
AGIF122861133
CINS118069840
VCAN122411939
CCIN107266994
DSM124412248
NPT124210854
NFB124175257
NLO107217049
NVG124296804
AROA105689564
TCA661853
ATD109594826
CSET123306600
AGB108907583
LDC111507148 111510351
NVL108568541
APLN108741365
PPYR116169263 116175369
OTU111421389
BMOR101737157
BMAN114243734
MSEX115450444 115454988
DPLKGM_209902
BANY112046118
MJU123875790
VCD124537203
MCIX123661773
PMAC106715713
PXU106113967
PRAP110994773
PBX123716025
PNAP125049437
ZCE119831778
CCRC123699263
LSIN126977961
HAW110376309
HZE124637915
TNL113505278
SLIU111362911
OFU114361758
PGW126374514
CCRN123298106
API100573944
DNX107172847
AGS114132652
RMD113558854
ACOO126834204
DVT126903455
BTAB109034781
NLU111046173
HVI124355500 124374551
MQU128996346 128996847
PHUPhum_PHUM477810
FOC113211844
TPAL117648095
ZNE110832360
CSEC111873849
SGRE126272564
IEL124164328
FCD110858522
DPXDAPPUDRAFT_323291
DMK116917776
DPZ124329492
PVM113804207
PJA122247712
PCHN125027928
PMOO119573268
HAME121855459
PCLA123773332
CQD128701725
PTRU123517431
ESN127009318
HAZT108669375
PPOI119105256
ISC8026257
DSV119431916
RSAN119379608
RMP119176206
VDE111253455 111253463
VJA111263138 111266369
TUT107360779
DPTE113795524
DFR124491093
CSCU111629437 111629438 111632546
PTEP107447925 107449771
UDV129219626 129220234
SDM118182070
LPOL106462139
PMEO129590612
CELCELE_F26E4.11(hrdl-1)
CBRCBG_03795(Cbr-hrdl-1)
CRQGCK72_000631
BMYBM_BM3622(Bma-hrdl-1)
LOALOAG_05873
LGILOTGIDRAFT_92759
PVUL126816343
PCAN112553473
BGT106068912
GAE121388026
HRF124112222
HRJ124284079
CRG105329658
CVN111133262 111133263
CANU128190590
OED125681974
MYI110443727
PMAX117337342
MCAF127701485
MMER123548993
RPHI132754531
DPOL127858536
OBI106876431
OSN115212750
LAK106150884
SMMSmp_047420 Smp_150210.1
SHXMS3_00005372
OVIT265_00286 T265_10644
EGLEGR_02949
NVE5505888
EPA110240131
ATEN116306414
ADF107345732
AMIL114965122
PDAM113667542
SPIS111342075
DGT114532743
XEN124436172
HMG100206548
HSY130614554
TADTRIADDRAFT_24155
AQU100637500
ATHAT4G25230(RIN2) AT5G51450(RIN3)
ALY9300187 9305754
CRB17875880 17878174
CSAT104720125 104722445 104725655 104726164 104730915
EUSEUTSA_v10014220mg EUTSA_v10024774mg
BRP103834881 103861538 103863030
BNA106359865 106361325 106361726 106374473 106389175 106411538
BOE106301316 106312688 106324686
RSZ108822395 108848289 130502373
THJ104808282 104825064
CPAP110823179
CIT102629805
CICCICLE_v10004605mg
PVY116126562
MINC123197989 123225875
TCC18605361
GRA105764900
GHI107911089 107933504 107946848 107953639
GAB108455767 108479564
HSYR120127575 120174237 120186981 120215906
DZI111285880 111289342
EGR104424344
GMX100819656 100820578
GSJ114409462 114417404
PVUPHAVU_005G0101001
VRA106760708
VAR108334013
VUN114174664
VUM124832636
CCAJ109805843
APRC113854233
MTR11410500
TPRA123915657
CAM101489425
PSAT127085999
VVO131593436
LJALj3g3v0807670.1(Lj3g3v0807670.1) Lj3g3v0807670.2(Lj3g3v0807670.2)
ADU107471903
AIP107622906
AHF112716896 112782705
LANG109329773 109335503 109345997
PCIN129315836
QSAO6P43_001625 O6P43_029831
FVE101303274
RCN112199162
PPER18785559
PMUM103333355
PAVI110764711
PDUL117619860
MDM103439637
MSYL126627944 126629121
PXB103932670 103959825 103961957 103963396
ZJU107414340
MNT21386926
CSAV115705422 115705628
CSV101219800
CMO103491275
BHJ120078415
MCHA111023642
CMAX111491111
CMOS111459248
CPEP111795351
RCU8266070
JCU105648608
HBR110658332 110669592
MESC110617427 110630824
POP7457713 7465507
PEU105115605 105121399 105132289
PALZ118028613 118036021
JRE108987395 109014079
CILL122303122 122306940
CAVE132180827
QSU111989475
QLO115960163
TWL120004108
VVI100241573
VRI117933098
SLY101247432
SPEN107023515
SOT102592947
SSTN125874865
SDUL129900878
CANN107873370
LBB132638901
NTA107760187 107770352
NSY104238923
NTO104098886
NAU109215113
INI109194059
ITR115999718
SIND105160599
OEU111377109 111391311
EGT105971849
SSPL121794498 121798522 121801822 121808658
SMIL130995487
APAN127259687
HAN110869196 110905037
ECAD122603451
LSV111901627 111910862
CCAV112516944
DCR108223229
CSIN114303410 114320103
RVL131318920
AEW130762201 130764446 130769062
BVG104906612
SOE110782367
CQI110689361 110718310
ATRI130825422
MOF131146338
NNU104598546
MING122074129 122081608
TSS122664356 122669800
PSOM113284311 113355490
OSA4343241
DOSAOs07t0484300-01(Os07g0484300)
OBR102718757
OGL127779196
BDI100824161
ATS109744768
TDC119354388 119363609
TAES123044811 123052629 123188480
TUA125537156
LPER127333692
LRD124670031 124674545
SBI8077439
ZMA100284836 103633177
SITA101766024
SVS117844942
PVIR120658318 120688134
PHAI112879861
PDA103705135 103712148
EGU105043621 105054014
MUS103975701 103990408
ZOF122019866 122019868 122041384 122045881
DCT110094867 110111279
PEQ110023015 110030153
AOF109839637
MSIN131233895
NCOL116266013
ATR18436990
SMOSELMODRAFT_42421 SELMODRAFT_42433
PPP112280279 112290433
CVRCHLNCDRAFT_134959
APROF751_2271
MBRMONBRDRAFT_24231
SREPTSG_09774
DDIDDB_G0279345(amfr)
DPPDICPUDRAFT_53219
DFADFA_04765(amfr)
ACANACA1_191030
PIFPITG_08469
PSOJPHYSODRAFT_299639
GTTGUITHDRAFT_110768
NGRNAEGRDRAFT_74164
 » show all
Reference
1  [PMID:15994556]
  Authors
Cadwell K, Coscoy L.
  Title
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.
  Journal
Science 309:127-30 (2005)
DOI:10.1126/science.1110340
Reference
2  [PMID:28604676]
  Authors
Wang YJ, Bian Y, Luo J, Lu M, Xiong Y, Guo SY, Yin HY, Lin X, Li Q, Chang CCY, Chang TY, Li BL, Song BL.
  Title
Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
  Journal
Nat Cell Biol 19:808-819 (2017)
DOI:10.1038/ncb3551
Reference
3  [PMID:31953408]
  Authors
Zhou ZS, Li MX, Liu J, Jiao H, Xia JM, Shi XJ, Zhao H, Chu L, Liu J, Qi W, Luo J, Song BL.
  Title
Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.
  Journal
Nat Commun 11:379 (2020)
DOI:10.1038/s41467-019-14231-w
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.36
IUBMB Enzyme Nomenclature: 2.3.2.36
ExPASy - ENZYME nomenclature database: 2.3.2.36
BRENDA, the Enzyme Database: 2.3.2.36

DBGET integrated database retrieval system