KEGG ENZYME: 2.3.2.37

ENZYME: 2.3.2.37

Entry

EC 2.3.2.37                 Enzyme

Name

ergosteryl-3beta-O-L-aspartate synthase;
ErdS

Class

Transferases;
Acyltransferases;
Aminoacyltransferases

Sysname

L-aspartyl-tRNAAsp:ergosterol-3beta-O-L-aspartyltransferase

Reaction(IUBMB)

L-aspartyl-tRNAAsp + ergosterol = tRNAAsp + 1-(ergostan-3beta-yl)-L-aspartate [RN:R13187]

Reaction(KEGG)

R13187

Substrate

L-aspartyl-tRNA(Asp) [CPD:C02984];
ergosterol [CPD:C01694]

Product

tRNA(Asp) [CPD:C01638];
1-(ergostan-3beta-yl)-L-aspartate

Comment

The enzyme, detected in fungal species that belong to the Ascomycota and Basidiomycota phyla and characterized from Aspergillus fumigatus, is bifunctional. The AspRS domain catalyses the transfer of L-aspartate to tRNAAsp (EC 6.1.1.12), while the second domain carries out the transfer of L-aspartate to the 3beta-hydroxyl of ergosterol.

History

EC 2.3.2.37 created 2023

Orthology

K24278

ergosteryl-3beta-O-L-aspartate synthase

Genes

NCR:

NCU07082

NTE:	NEUTE1DRAFT86925(NEUTE1DRAFT_86925)

SMP:	SMAC_03897

PAN:	PODANSg3375

PBEL:

QC761_405110(DPS1)

PPSD:

QC762_405110(DPS1)

PPSP:

QC763_405110(DPS1)

PPSA:

QC764_405110(DPS1)

TTT:	THITE_2109401

MTM:	MYCTH_59106

MGR:

MGG_13783

PPEI:

PpBr36_05421

PGRI:

PgNI_02914

TMN:	UCRPA7_4375

FGR:	FGSG_01976

FPU:	FPSE_09210

FPOA:

FPOAC1_002103

FVN:	FVRRES_02346

FVR:	FVEG_07262

FOX:	FOXG_04148 FOXG_16675 FOXG_16738

NHE:	NECHADRAFT_96752

FFC:	NCS54_01271900

FKR:	NCS57_01237500

FMU:	J7337_010725

TRE:	TRIREDRAFT_48819

TRR:	M419DRAFT_110431

MAW:

MAC_06778

MAJ:

MAA_01125

PCHM:

VFPPC_03564

CMT:

CCM_02981

AMUS:

LMH87_006953

PLJ:	VFPFJ_00684

PTKZ:

JDV02_007963(DPS1)

VAL:	VDBG_03134

VDA:	VDAG_02041

CFJ:	CFIO01_08749

CLUP:

CLUP02_06618

CHIG:

CH63R_01433

ELA:	UCREL1_7942

PFY:	PFICI_05047

SSL:	SS1G_11475

BFU:	BCIN_08g05800

MBE:

MBM_03824

PSCO:

LY89DRAFT_656573

GLZ:	GLAREA_06461

ANI:	ANIA_00314

AFM:	AFUA_1G02570

ACT:	ACLA_031840

NFI:	NFIA_022050

AOR:	AO090005000838

ANG:	An01g05630

AFV:	AFLA_003657

ALUC:

AKAW2_20668S

ACHE:

ACHE_11809S

APUU:

APUU_11796A

PCS:	N7525_004213

PDP:	PDIP_63500

POU:	POX_b03344

TMF:	EYB26_008489

TRG:	TRUGW13939_00066

CIM:	CIMG_04731

CPW:	CPC735_071000

URE:	UREG_06784

PBL:	PAAG_05664

PBN:	PADG_07732

ABE:

ARB_01269

TVE:

TRV_01140

AJE:	HCAG_04705

BGH:	BDBG_04515

PNO:	SNOG_04267

PTE:

PTT_11927

BZE:	COCCADRAFT_7647

BSC:	COCSADRAFT_37947

BOR:	COCMIDRAFT_80535

AALT:

CC77DRAFT_833387

ARAB:

EKO05_0002150

ZTR:	MYCGRDRAFT_53676

PFJ:	MYCFIDRAFT_160086

FFU:	CLAFUR5_00532

CBET:

CB0940_01174

BCOM:

BAUCODRAFT_37211

NPA:	UCRNP2_4367

CNE:

CNG00400

CNB:

CNBG4380

CNG:	CNAG_03563

CGI:	CGB_G6320C

CDEU:

CNBG_2059

TVS:	TRAVEDRAFT_62662

DSQ:	DICSQDRAFT_137523

PCO:	PHACADRAFT_118899

SHS:	STEHIDRAFT_135399

PSQ:	PUNSTDRAFT_125466

ADL:	AURDEDRAFT_143959

GTR:	GLOTRDRAFT_131655

MRR:	Moror_5228

E1B28_003413

SCM:	SCHCO_01196424(SCHCODRAFT_01196424)

UMA:	UMAG_10270

PFP:	PFL1_06798

SGRA:

EX895_003994

MGL:

MGL_0589

MRT:

MRET_4297

MSYM:

MSY001_2768

» show all

Reference

1 [PMID:32541034]

Authors

Yakobov N, Fischer F, Mahmoudi N, Saga Y, Grube CD, Roy H, Senger B, Grob G, Tatematsu S, Yokokawa D, Mouyna I, Latge JP, Nakajima H, Kushiro T, Becker HD

Title

RNA-dependent sterol aspartylation in fungi.

Journal

Proc Natl Acad Sci U S A 117:14948-14957 (2020)
DOI:10.1073/pnas.2003266117

Sequence

[afm:AFUA_1G02570]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.2.37

IUBMB Enzyme Nomenclature:

2.3.2.37

ExPASy - ENZYME nomenclature database:

2.3.2.37

BRENDA, the Enzyme Database:

2.3.2.37

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (173)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (105)   
   KEGG MGENES (67)   
All databases (178)   

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