KEGG ENZYME: 2.3.3.14

ENZYME: 2.3.3.14

Entry

EC 2.3.3.14                 Enzyme

Name

homocitrate synthase;
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating);
acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase;
homocitrate synthetase;
HCS

Class

Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer

Sysname

acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Reaction(IUBMB)

acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA [RN:R00271]

Reaction(KEGG)

R00271

Substrate

acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
2-oxoglutarate [CPD:C00026]

Product

(2R)-2-hydroxybutane-1,2,4-tricarboxylate;
CoA [CPD:C00010]

Comment

Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3].

History

EC 2.3.3.14 created 1972 as EC 4.1.3.21, transferred 2002 to EC 2.3.3.14

Pathway

ec00300

Lysine biosynthesis

ec00620

Pyruvate metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K01655

homocitrate synthase

K02594

homocitrate synthase NifV

K10977

methanogen homocitrate synthase

Genes

SCE:	YDL131W(LYS21) YDL182W(LYS20)

SEUB:

DI49_0897

SPAO:

SPAR_D00610 SPAR_D01060

AGO:	AGOS_ADR107W

ERC:

Ecym_8045

KLA:	KLLA0_E23695g KLLA0_F05489g

KMX:	KLMA_10771(LYS21) KLMA_60493(LYS21)

LTH:	KLTH0E12848g KLTH0H02486g

VPO:	Kpol_2000p11

ZRO:	ZYRO0A13222g ZYRO0C09416g

CGR:	CAGL0J06402g CAGL0J09240g

NCS:	NCAS_0A13800(NCAS0A13800) NCAS_0E03640(NCAS0E03640)

NDI:	NDAI_0A02240(NDAI0A02240) NDAI_0A02990(NDAI0A02990)

TPF:	TPHA_0P00840(TPHA0P00840)

TBL:	TBLA_0A05940(TBLA0A05940)

TGB:	HG536_0C05440 HG536_0H02920

TDL:	TDEL_0B02910(TDEL0B02910) TDEL_0H01490(TDEL0H01490)

KAF:	KAFR_0B01160(KAFR0B01160)

KNG:	KNAG_0B02880(KNAG0B02880) KNAG_0C04080(KNAG0C04080)

ZMK:	HG535_0A05750 HG535_0G01540

PPA:	PAS_chr1-1_0313 PAS_chr1-4_0421

DHA:	DEHA2D13222g DEHA2F08514g

PIC:	PICST_28701(LYS21) PICST_89386(LYS22)

PGU:	PGUG_01126 PGUG_01480

SPAA:

SPAPADRAFT_136285(LYS22) SPAPADRAFT_58182

LEL:	PVL30_001014(LYS1_1) PVL30_001780(LYS21)

CAL:	CAALFM_C104730CA(LYS21) CAALFM_C204460WA(LYS22)

CTP:	CTRG_01594 CTRG_04686

COT:	CORT_0A12020 CORT_0B06650

CDU:	CD36_04470 CD36_19070

CTEN:

CANTEDRAFT_113002 CANTEDRAFT_115851

YLI:	YALI0F31075g

CLU:	CLUG_01219 CLUG_05100

CLUS:

A9F13_03g01375 A9F13_06g00154

CAUR:

CJI96_0001452 CJI96_0002255

SLB:	AWJ20_418(LYS21)

PKZ:	C5L36_0C01170 C5L36_0D05690

BNN:	FOA43_003157(LYS21)

BBRX:

BRETT_000905(LYS21_1) BRETT_003395(LYS21_2)

OPA:	HPODL_02806 HPODL_04767

SLUD:

SCDLUD_000290 SCDLUD_002024

NCR:	NCU05526(lys-5)

NTE:	NEUTE1DRAFT68872(NEUTE1DRAFT_68872)

SMP:	SMAC_00737

PAN:	PODANSg2772

PBEL:

QC761_404040(LYS21)

PPSD:

QC762_404040(LYS21)

PPSP:

QC763_404040(LYS21)

PPSA:

QC764_404040(LYS21)

TTT:	THITE_2110530

MTM:	MYCTH_2307131

CTHR:

CTHT_0044760

MGR:

MGG_01092

PPEI:

PpBr36_08045

PGRI:

PgNI_08149

TMN:	UCRPA7_2646

SSCK:

SPSK_02501

FGR:	FGSG_03993 FGSG_11054

FPU:	FPSE_02427 FPSE_05284

FPOA:

FPOAC1_006422(LYS1_1) FPOAC1_009794(LYS1_2)

FVN:	FVRRES_07028 FVRRES_10448

FVR:	FVEG_00366 FVEG_08487 FVEG_11679

FOX:	FOXG_01149 FOXG_01159

NHE:	NECHADRAFT_104905 NECHADRAFT_90471

FFC:	NCS54_00169600 NCS54_00936300

FKR:	NCS57_00167300 NCS57_00956000

FMU:	J7337_001595(LYS1_1) J7337_010079

TRE:	TRIREDRAFT_123471

TRR:	M419DRAFT_111054

MAW:	MAC_04163 MAC_04755

MAJ:	MAA_04642 MAA_08803

PCHM:

VFPPC_01004 VFPPC_01351

CMT:

CCM_06007

AMUS:

LMH87_005390

PLJ:	VFPFJ_03902

PTKZ:

JDV02_002478(LYS21)

VAL:	VDBG_04044 VDBG_07402

VDA:	VDAG_01275 VDAG_06110

CFJ:	CFIO01_11607

CLUP:

CLUP02_13734

CHIG:

CH63R_05833

SAPO:

SAPIO_CDS8181

ELA:	UCREL1_11150

PFY:	PFICI_06350 PFICI_09647

SSL:	SS1G_14306

BFU:	BCIN_14g05400

MBE:

MBM_09052

PSCO:

LY89DRAFT_684190

GLZ:	GLAREA_07760

ANI:	ANIA_01990

AFM:	AFUA_4G10460

ACT:	ACLA_049660

NFI:	NFIA_105610

AOR:	AO090003001165 AO090124000027

ANG:	An04g06210

AFV:	AFLA_000502 AFLA_009184

ALUC:

AKAW2_51586A(LYS1_2)

ACHE:

ACHE_10778S(LYS1_1)

APUU:

APUU_21064S(LYS1_1)

PCS:	N7525_005048

PDP:	PDIP_24800

POU:	POX_f08046

TMF:	EYB26_005247

TRG:	TRUGW13939_02747

CIM:	CIMG_09081

CPW:	CPC735_015150

URE:	UREG_05150

PBL:	PAAG_07089

PBN:	PADG_01615

ABE:

ARB_01923

TVE:

TRV_02108

AJE:	HCAG_06098

BGH:	BDBG_02311

PNO:	SNOG_08956

PTE:

PTT_15621

BZE:	COCCADRAFT_101614

BSC:	COCSADRAFT_32571

BOR:	COCMIDRAFT_95545

AALT:

CC77DRAFT_1052185

ARAB:

EKO05_0009236

ZTR:	MYCGRDRAFT_110230

PFJ:	MYCFIDRAFT_86887

FFU:	CLAFUR5_12241

CBET:

CB0940_11003

BCOM:

BAUCODRAFT_39689

NPA:	UCRNP2_8181

TML:	GSTUM_00009173001

SPO:	SPBC1105.02c(lys4)

SOM:	SOMG_00682(lys4)

CNE:

CND01200

CNB:

CNBD5100

CNG:	CNAG_00992

CGI:	CGB_D3430W

CDEU:

CNBG_0572

TMS:	TREMEDRAFT_44559

TASA:

A1Q1_00939

CCAC:

CcaHIS019_0703000(LYS21)

PPL:	POSPLDRAFT_89192

TVS:	TRAVEDRAFT_110523

DSQ:	DICSQDRAFT_45747

PCO:	PHACADRAFT_159123

SHS:	STEHIDRAFT_90937

HIR:	HETIRDRAFT_316739

ADL:	AURDEDRAFT_112769

FME:	FOMMEDRAFT_76994

GTR:	GLOTRDRAFT_112070

RSX:	RhiXN_02664

LBC:	LACBIDRAFT_291144

CCI:	CC1G_06438

ABP:	AGABI1DRAFT114278(AGABI1DRAFT_114278)

ABV:	AGABI2DRAFT191298(AGABI2DRAFT_191298)

PCUB:

JR316_0006175

MRR:	Moror_4622

E1B28_011484(LYS4_1)

SCM:	SCHCO_02503178(SCHCODRAFT_02503178)

CPUT:

CONPUDRAFT_80635

SLA:	SERLADRAFT_468311

WSE:	WALSEDRAFT_42693

WIC:	J056_002016

UMA:	UMAG_04115

PFP:	PFL1_06052

SGRA:

EX895_001568

MGL:

MGL_3987

MRT:

MRET_4216

MSYM:

MSY001_2206

PGR:	PGTG_01903

PTRC:

PtA15_10A706

PSTR:

Pst134EA_019740

MLR:	MELLADRAFT_50387

MBR:	MONBRDRAFT_34312

SRE:	PTSG_03420

NGR:	NAEGRDRAFT_34642

ENR:	H650_03260

ENF:	AKI40_3036

KPV:	KPNIH29_17575

KVA:

Kvar_1593

KPE:	KPK_1704(nifV)

KPK:	A593_02165

KVD:	KR75_26170

KVQ:	SP68_06315

KOX:

KOX_24970

KOE:

A225_3846

KOY:	J415_12630

KOM:	HR38_23055

KOK:	KONIH1_19295

KOC:	AB185_16985

KQU:	AVR78_21560

KQV:	B8P98_09530(nifV)

KLL:	BJF97_19205

KGR:	JJJ10_09475(nifV)

KPAS:

LUW96_25515(nifV)

KLC:	K7H21_09545(nifV)

KLM:	BWI76_18860

REE:	electrica_03306(leuA_2)

RON:	TE10_14840

RTG:	NCTC13098_03592(leuA_5)

KSA:	C813_03870

KOR:	AWR26_13330(nifV)

KRD:	A3780_10680(nifV)

KPSE:

IP581_10875(nifV)

KOO:	O9K67_13015(nifV)

KIN:	AB182_11850

PDZ:	HHA33_15750(nifV)

METY:

MRY16398_27800

EBC:	C2U52_22685(nifV)

RACE:

JHW33_22800(nifV)

RAQ:	Rahaq2_5100

RAA:

Q7S_25861

PROD:

PCO85_20165(nifV)

SERA:

Ser39006_005380(nifV)

SERQ:

CWC46_05375(nifV)

ECA:	ECA2944(nifV)

PATR:

EV46_14530

PATO:

GZ59_29480(nifV)

PPOA:

BJK05_08570

PCAC:

OI450_10585(nifV)

DDD:	Dda3937_02173(nifV)

DSO:	A4U42_06295

CED:	LH89_15245

DFN:	CVE23_19690(nifV)

DDQ:

DDI_3740

DDA:	Dd703_0505

BGJ:	AWC36_07340 AWC36_21445

BRB:	EH207_08550(nifV)

BNG:	EH206_10210(nifV)

BIZ:	HC231_11325(nifV)

SLIG:

GTU79_13535(nifV)

PAM:	PANA_3289(leuA2)

PLF:	PANA5342_0779

PAQ:	PAGR_g0792

PAO:	Pat9b_4710

PPHO:

CTZ24_25135(nifV)

XBV:	XBW1_2048(leuA)

VNA:	PN96_19245

VEJ:	VEJY3_18751

VAS:	GT360_06370(nifV)

VZI:	G5S32_17245(nifV)

PSA:	PST_1352(nifV)

PSR:	PSTAA_1384(nifV)

AVN:	Avin_01640(nifV)

AVL:	AvCA_01640(nifV)

AVD:	AvCA6_01640(nifV)

ACX:	Achr_1500(nifV)

SDK:	KHX94_12855(nifV)

SYK:	KDN34_14205(nifV)

SAVI:

JYB87_02715(nifV)

AGZ:	M0C34_08825(nifV)

AGQ:	LQZ07_13650(nifV)

TTU:	TERTU_1590(nifV)

MCA:	MCA0254(nifV)

METU:

GNH96_04000(nifV)

MMEO:

OOT43_11075(nifV)

MMT:	Metme_3108

MDN:	JT25_013605

MDH:	AYM39_04515

MKO:	MKLM6_0904

METL:

U737_20460(nifV)

MPAD:

KEF85_01905(nifV)

MELL:

IVG45_07500(nifV)

MMOT:

QZJ86_03645(nifV)

MBUR:

EQU24_17350(nifV)

MPSY:

CEK71_18900(nifV)

MMAI:

sS8_5511

MSZE:

MSZNOR_0032(nifV)

MMOB:

F6R98_03690(nifV)

MOZ:	MoryE10_26780

MESL:

KKZ03_16595(nifV)

TIG:

THII_3088

BLEP:

AL038_12335(nifV)

THIS:

HZT40_02960(nifV)

TUN:	J9260_09745(nifV)

TLO:	J9253_07215(nifV)

TSB:	HMY34_13210(nifV)

ALV:	Alvin_1499

ATEP:

Atep_22370

TVI:	Thivi_4287

TMB:	Thimo_3234

MPUR:

MARPU_02910

TSY:	THSYN_10705

TTP:	E6P07_09595(nifV)

THIP:

N838_15805(nifV)

CJAP:

GWK36_11715(nifV)

THIM:

KFB96_21875(nifV)

TBOG:

LT988_18055(nifV)

TLR:	Thiosp_03513(leuA_2)

TFRI:

Thiofri_02031(leuA_1)

TWG:	Thiowin_03922(leuA_3)

HHA:

Hhal_0279

HHK:	HH1059_12130

HHC:	M911_10550

EBS:	ECTOBSL9_3086

AAEO:

BJI67_12660

HAZ:	A9404_01550

SEDS:

AAY24_16725

HAM:

HALO1620

NIK:	F5I99_00395(nifV)

GSN:	YC6258_02011

TAU:

Tola_2344

GBI:	PG2T_00440

ACII:

C4901_14850(nifV)

ATY:	A9R16_013735(nifV)

CDIZ:

CEDIAZO_02286(frbC)

VFF:	VITFI_CDS1636

AQL:	BXU06_12020

CTI:	pRALTA_0383(nifV)

BOK:

DM82_5473

BOC:

BG90_5135

BUU:	WS70_24305

BVI:	Bcep1808_5987

BVE:	AK36_5464(nifV)

BSTG:

WT74_17305

BUG:	BC1001_PA6327(nifV1) BC1001_PA6490(nifV2)

BUK:

MYA_5482

BXE:

Bxe_B1438

BXB:	DR64_6744(nifV)

BPH:

Bphy_7741

BGE:	BC1002_6915

BPX:	BUPH_08515(nifV)

PSPW:

BJG93_028040(nifV) BJG93_16455(nifV) BJG93_16555(nifV) BJG93_32345(nifV)

PARB:

CJU94_33135(nifV)

PDIO:

PDMSB3_1662.1(nifV)

PSAA:

QEN71_42230(nifV)

TCAR:

U0034_27400(nifV)

RAC:	RA876_02570

PNA:

Pnap_2310

HTN:	KI616_07790(nifV)

RGE:	RGE_43100(nifV)

RBN:	RBXJA2T_04428

IDC:	LRM40_03230(nifV)

LCH:

Lcho_1366

HSE:	Hsero_2835(nifV)

HSZ:	ACP92_14195

HRB:	Hrubri_2359(nifV)

BBAG:

E1O_13410

METR:

BSY238_1244(nifV)

NPV:	OHM77_01845(nifV)

SLT:

Slit_0807

FAM:	OYT1_ch1085

FKU:	FGKAn22_10410

SEME:

MIZ01_0760

SULF:

CAP31_00225

SNIV:

SFSGTM_04470

SLAC:

SKTS_08810

DSU:

Dsui_0578

ARES:

IWH25_06420(nifV)

AIQ:	Azoinq_05900(nifV)

NIV:	JY500_11765(nifV)

RBH:	B4966_06565

DAR:

Daro_1398

DEY:	HYN24_06635(nifV)

DDEN:

KI615_08440(nifV)

QAU:	KI612_04755(nifV)

FLE:	KI610_08670(nifV)

AZO:	azo0551(nifV)

AOA:

dqs_0561

AZA:

AZKH_0773

AZI:	AzCIB_0674

AZD:	CDA09_08305(nifV)

AZR:	CJ010_03625(nifV)

AZQ:	G3580_19130(nifV)

ACOM:

CEW83_19555(nifV)

ZPA:	C3497_06150(nifV)

FMY:	HO273_13100(nifV)

APP:	CAP2UW1_4375

MCI:	Mesci_5834

MOP:	Mesop_6408

MAM:	Mesau_05881

MAMO:

A6B35_32285

MOH:	IHQ72_34265(nifV)

SAME:

SAMCFNEI73_pB0094(nifV)

BRA:	BRADO5390(nifV)

BBT:	BBta_5875(nifV)

BRS:

S23_45990

AOL:

S58_23130

BRC:	BCCGELA001_31050

BIC:	LMTR13_26450

BRO:	BRAD285_1843(nifV)

BRQ:	CIT40_01070(nifV)

BARH:

WN72_08700(nifV)

BVZ:	BRAD3257_7801(nifV)

BEL:	BE61_80510(nifV)

BAUT:

QA635_34595(nifV)

BBRA:

QA636_36110(nifV)

BPAH:

QA639_34690(nifV)

BXN:	I3J27_34175(nifV)

BROS:

QUH67_34295(nifV)

BRAZ:

LRP30_06940(nifV)

RPA:	TX73_023930(nifV)

RPB:

RPB_0982

RPC:

RPC_4450

RPD:

RPD_1086

RPE:

RPE_4520

RPT:

Rpal_5088

RPX:	Rpdx1_4785

XAU:

Xaut_0150

XDI:	EZH22_03890(nifV)

AZC:

AZC_3389

MET:

M446_3580

MLD:	U0023_27450

BID:

Bind_0485

MSL:

Msil_3619

MTUN:

MTUNDRAET4_2336(nifV)

MLG:	CWB41_08170(nifV)

MEDK:

QEV83_10700(nifV)

HMC:	HYPMC_3635(nifV)

RVA:

Rvan_1127

RLAC:

QMO75_08525(nifV)

BVR:

BVIR_2279

BLAG:

BLTE_12000

MSC:	BN69_2668(nifV)

MBRY:

B1812_07905

MROS:

EHO51_16910(nifV)

MHEY:

H2LOC_019835(nifV)

MPAR:

F7D14_08630(nifV) F7D14_19185(nifV)

MIWA:

SS37A_23380

MTW:	CQW49_08665(nifV)

MECQ:

MSC49_11400

PLEO:

OHA_1_01553(leuA_2)

HDI:	HDIA_0314(nifV)

MEY:	TM49_15540

YAN:	AYJ57_00265

SAGU:

CDO87_16420(nifV)

RSP:	RSP_0529(nifV)

RSH:	Rsph17029_2181

RSQ:	Rsph17025_1258

RSK:	RSKD131_1864

CAZT:

LV780_05935(nifV)

RCP:	RCAP_rcc03269(nifV)

RBL:	B6K69_06205

RSU:

NHU_01423

RHM:	B5V46_06570

RHC:

RGUI_2008

DAA:	AKL17_1562

ZMO:

ZMO1835

ZMN:

Za10_1400

ZMM:

Zmob_1319

ZMB:

ZZ6_1307

ZMI:

ZCP4_1343

ZMC:	A265_01343

ZMR:	A254_01342

ZMP:	Zymop_1299

NDR:	HT578_08530(nifV)

SPHI:

TS85_14275

GDI:	GDI0449(nifV)

GDJ:

Gdia_1557

RAP:	RHOA_0946(nifV)

AZL:	AZL_006540(leuA)

ALI:	AZOLI_0543(nifV)

ABS:	AZOBR_70111(nifV)

ABQ:	ABAZ39_10085

ABF:	AMK58_04575

ATI:	AL072_01085

AHU:	A6A40_02225

AZT:	TSH58p_07725(nifV)

AZM:	DM194_01955(nifV)

AZZ:	DEW08_14855(nifV)

AOZ:	HUE56_20495(nifV)

AARE:

D3093_13575(nifV)

AZS:	E6C72_07255(nifV)

NAO:	Y958_05410(nifV)

SKT:	IGS68_09325(nifV)

SMUC:

JL100_017910(nifV)

SROE:

JL101_016750(nifV)

RRU:

Rru_A2269

RRF:

F11_11670

RCE:	RC1_3693(nifV)

RPM:	RSPPHO_01122

MGY:	MGMSRv2__0313(nifV)

MGRY:

MSR1_18880(leuA_3)

MAGX:

XM1_3948(nifV)

MAGN:

WV31_08715

DEX:	HWD60_15190(nifV)

DVN:	HQ394_18590(nifV)

MAG:

amb1562

VSU:	P3M64_06760(nifV)

THAR:

T8K17_00425

TMO:

TMO_c0649

MGM:

Mmc1_1190

AFR:	AFE_1506(nifV)

AFE:	Lferr_1224

AFI:	Acife_1634

AFJ:	AFERRID_23260

AFP:	K1Y48_11625(nifV)

WSU:	WS1396(NIFV1)

SULG:

FJR48_03500(nifV)

SBAL:

HUE88_05810(nifV)

SMAS:

HUE87_07715(nifV)

SMAX:

FJR03_02925(nifV)

SKU:	Sulku_1509

SULR:

B649_06590

SBA:	Sulba_0991

SMUL:

SMUL_1208(nifV)

SHAL:

SHALO_1193

SULS:

Sdiek1_1277

SULJ:

SJPD1_1226

SULT:

FA592_12340(nifV)

ANT:	Arnit_0082

AELL:

AELL_0053(nifV)

ASUI:

ASUIS_0055(nifV)

AVP:	AVENP_0069(nifV)

ADZ:	ADFLV_0079(nifV)

ARC:

ABLL_0069

PACO:

AACT_0059(nifV)

AMOL:

AMOL_2269(nifV)

HEBR:

AEBR_0107(nifV)

AANA:

AANAER_0113(nifV)

SMAB:

LN246_08675(nifV)

GSU:	GSU0937(nifV)

GSK:	KN400_0924(nifV)

GME:	Gmet_0692(nifV)

GPI:	GPICK_12140(aksA)

GBZ:	JZM60_09095(nifV)

GEM:

GM21_2146

GEB:

GM18_1861

GEF:	FO488_16855(nifV)

GUR:

Gura_3368

GEO:	Geob_2573(nifV)

GLO:

Glov_0424

TAMM:

GEAMG1_0047(leuA)

GBM:	Gbem_2073(nifV)

GBN:	GEOBRER4_11490(nifV)

GER:	KP004_09360(nifV)

GSUB:

KP001_05825(nifV)

GNT:	KP003_08765(nifV)

GPL:	M1B72_11410(nifV)

GHC:	L9S41_01180(nifV)

PCA:	Pcar_2110(nifV)

PACE:

A6070_04770(aksA)

PEF:	A7E78_00905

PPD:

Ppro_3466

DEU:

DBW_0078

DVE:	DESUT3_35970(nifV)

DEP:	AOP6_2655(nifV)

DES:	DSOUD_2514(nifV)

DFL:

DFE_1493

PSYF:

N1030_07215

DSB:	LN040_09490

DSA:	Desal_0448

DAF:	Desaf_0764

DAS:

Daes_1020

DPI:

BN4_20067

DEJ:	AWY79_07525

PPRF:

DPRO_3401

PSEL:

GM415_09385

DDN:	DND132_1299

PSEF:

PSDVSF_12630

PPOR:

JCM14722_09850

PTHE:

LF599_13850

DVU:

DVUA0016

DVL:

Dvul_3089

DVM:

DvMF_2612

DVG:	Deval_3110

CLIH:

KPS_003031

DBA:

Dbac_0833

DESU:

NLA06_04290

THEW:

TDMWS_07920

DSF:

UWK_00329

DAK:	DaAHT2_2478

ECOM:

QTN59_09115

DAL:

Dalk_1511

DAT:	HRM2_09760(nifV1)

DWD:	DSCW_30840(nifV)

DALK:

DSCA_50000(nifV)

DLI:

dnl_58130

DEK:	DSLASN_16140(nifV)

TID:	Thein_1048

TAV:	G4V39_02725

TMAI:

FVE67_04275

ADE:

Adeh_1436

ACP:	A2cp1_2511

AFW:	Anae109_2393

ANK:	AnaeK_2424

AORY:

AMOR_52870

APAU:

AMPC_18610

BRY:	M0696_19635

PARH:

I5S86_23695

PPOY:

RE92_06730

PTA:	HPL003_13115

PSAB:

PSAB_18730

PDU:	PDUR_11815 PDUR_11820 PDUR_11870 PDUR_21125

PBD:	PBOR_29310

PGM:	PGRAT_26390

POD:	PODO_25015

PAEN:

P40081_30915

PAEQ:

R50912_27665

PSTE:

PSTEL_11485 PSTEL_20960

PAEA:

R70723_26505

PAEE:

R70331_25210

PAEH:

H70357_28480

PRI:	PRIO_5532(nifV1)

PSON:

JI735_02625

PPEO:

ABE82_05165

PDH:	B9T62_25600

PKB:	B4V02_20020

PSOP:

KP014_14795 KP014_14800 KP014_25280

PTRI:

KDC22_27035

PTJ:	JRJ22_23555

PMAE:

LMZ02_18570

KYR:	CVV65_08095

CAC:	CA_C0260(nifV) CA_C0261(nifV)

CAE:	SMB_G0265 SMB_G0266(nifV)

CAY:	CEA_G0266 CEA_G0267(nifV)

CBK:	CLL_A0128(nifV)

CBT:	CLH_0112(nifV)

CBE:	Cbei_0069 Cbei_2011 Cbei_2012

CBZ:	Cbs_0069(aksA) Cbs_2011 Cbs_2012

CBEI:

LF65_00073(aksA) LF65_02180 LF65_02181

CKL:	CKL_1757(nifV1) CKL_1758(nifV2)

CKR:	CKR_1630 CKR_1631

CLJ:	CLJU_c04970(nivfV) CLJU_c04980(nifV)

CCB:	Clocel_2470 Clocel_2828 Clocel_2829

CLB:	Clo1100_2596 Clo1100_2597

CSR:	Cspa_c00800(leuA1) Cspa_c30980 Cspa_c30990

CPAS:

Clopa_3456 Clopa_3457

CPAT:

CLPA_c14420(nifVo) CLPA_c14430(nifVa)

CPAE:

CPAST_c14420(nifVo) CPAST_c14430(nifVa)

CSB:	CLSA_c00870(leuA2)

CAH:	CAETHG_2574 CAETHG_2575

CLT:	CM240_3129(nifV-ALPHA) CM240_3130

CBV:	U729_1236(nifV)

CACE:

CACET_c05330(leuA1)

CBUT:

ATN24_01900(aksA) ATN24_18615 ATN24_18620

CTYK:

CTK_C30180(nifV1) CTK_C30190(nifV2)

CEU:	A7L45_06285

CTAE:

BGI42_00525(nifV)

CFM:	BJL90_08385

CIA:	BEN51_00490

CSEP:

CP523_08375(nifV)

CDY:	F3K33_00395(nifV) F3K33_10025 F3K33_10030

CGAS:

J1C67_05445(nifV)

CLOS:

DMR38_02135 DMR38_02140

CMAH:

C1I91_22445(nifV)

CRW:	CROST_005400 CROST_005410(frbC)

CFB:	CLFE_043140(frbC) CLFE_043150

CAUN:

CLAUR_024660(frbC) CLAUR_024670

CNN:	CNEO_0115 CNEO_1051

CGEL:

psyc5s11_00880 psyc5s11_35420(nifV)

CINT:

HZF06_02710 HZF06_02715 HZF06_21910(nifV)

CTHD:

CDO33_05185

CCL:	Clocl_1269 Clocl_1270

CCE:

Ccel_1624

RHER:

EHE19_001280 EHE19_001285

RPAY:

P0092_14545 P0092_14550

EHA:	Ethha_1558 Ethha_1559 Ethha_2319 Ethha_2320

PETR:

QKW49_13980 QKW49_13985

CFEM:

HCR03_07075 HCR03_07080

SWO:

Swol_0375

SLP:

Slip_0508

SALQ:

SYNTR_0238

DSY:	DSY3883 DSY4262

DHD:	Dhaf_1059 Dhaf_1522

DDH:	Desde_1422

DDL:	Desdi_1263

DMT:	DESME_04715(aksA)

SGY:

Sgly_0729

DOR:	Desor_3919 Desor_5017

DAI:	Desaci_1215 Desaci_4028

DMI:	Desmer_3032 Desmer_4010

DED:	DHBDCA_p1403

DEC:	DCF50_p1415

DRS:	DEHRE_10895(aksA)

DCA:	Desca_1143 Desca_1729

PTH:	PTH_2520(LeuA)

DRM:

Dred_2339

DRU:	Desru_1307 Desru_3444

DFG:	B0537_12135

DAE:	Dtox_0785 Dtox_1022

DKU:	Desku_1675 Desku_3339

DAU:	Daud_0409 Daud_1035

TFR:	BR63_02025 BR63_02030 BR63_18265(nifV)

FWA:	DCMF_00390

AACX:

DEACI_3021 DEACI_3067

TJR:	TherJR_0701 TherJR_0874

DGI:	Desgi_2429 Desgi_2455

HMO:	HM1_0858(nifV) HM1_2993

HCV:	FTV88_1447 FTV88_2463

AWO:	Awo_c07850(nifV1) Awo_c07860(nifV2)

AWI:	CHL1_002971 CHL1_002972

HFV:	R50_0465(nifV)

CTHM:

CFE_2283 CFE_2579

ANR:	Ana3638_13875 Ana3638_13880

ACEL:

acsn021_23530(nifV_1) acsn021_23540(nifV_2)

ACHT:

bsdcttw_06510 bsdcttw_06520(nifV)

AHB:	bsdtb5_41550(nifV_1)

CLE:	Clole_0460 Clole_0461

CEW:	EKH84_05550 EKH84_05555

CBAR:

PATL70BA_2426(nifV)

VPY:	HZI73_16015(aksA)

AMT:	Amet_1321 Amet_3515

GFE:	Gferi_18755

CDF:	CD630_08320(aksA)

PDC:	CDIF630_00951

CDC:	CD196_0781

CDL:	CDR20291_0762

PDF:	CD630DERM_08320(aksA)

ROC:	HF520_05795(nifV)

PHX:	KGNDJEFE_02031(leuA_1)

TEM:	JW646_18060(nifV)

TGC:	L0P85_09935(nifV)

TMY:	TEMA_08990(frbC)

IBR:	NQ514_07780(nifV)

PEB:	O0R46_03245(nifV)

TTE:	TTE0472(LeuA2)

TEX:	Teth514_0415

THX:

Thet_0461

TPD:	Teth39_1820

TIT:

Thit_0443

TMT:	Tmath_0527

TBO:	Thebr_1867

TWI:	Thewi_0531

TKI:	TKV_c04530(leuA2)

CHY:	CHY_1104(nifV)

ADG:

Adeg_1099

TPZ:	Tph_c08720(nifV) Tph_c09000(leuA1)

TTM:

Tthe_2229

TTO:	Thethe_02308

TXY:	Thexy_1926

TSH:

Tsac_0029

AAUT:

ACETAC_08445(nifV)

MAS:	Mahau_0318

MTA:

Moth_1938

MTHO:

MOTHE_c19770(leuA2)

MTHZ:

MOTHA_c20560(leuA2)

TEP:	TepRe1_0154

TAE:	TepiRe1_0166(leuA)

BACG:

D2962_04380(nifV)

HOR:	Hore_08050

HALS:

D7D81_06125(nifV)

IFN:	GM661_03605(nifV)

PUF:	UFO1_0042 UFO1_0043 UFO1_3851 UFO1_3852

PFT:	JBW_01018 JBW_01019 JBW_04455 JBW_04456

MANA:

MAMMFC1_00442(leuA_1) MAMMFC1_00443(leuA_2) MAMMFC1_02645(leuA_6) MAMMFC1_02721(leuA_7) MAMMFC1_02722(leuA_8)

STED:

SPTER_11640(leuA_1) SPTER_11650(leuA_2) SPTER_42560(leuA_3) SPTER_42570(leuA_4)

SGR:

SGR_3476

SFI:

SFUL_3348

SCZ:	ABE83_19120

SCX:	AS200_21995

SRW:	TUE45_06894(leuA_4)

SGS:	AVL59_12485

SLAU:

SLA_3047

STIR:

DDW44_16575

SNK:	CP967_01820 CP967_15215

SSPO:

DDQ41_08085

SCAV:

CVT27_15430

SCYG:

S1361_31440(leuA4)

SGJ:	IAG43_00710

STRY:

EQG64_16275

SDD:	D9753_06820

SAKB:

K1J60_19040

STUB:

MMF93_32390

KAB:	B7C62_16015

FRA:	Francci3_4489

FRE:	Franean1_4071

FAL:	FRAAL6814(nifV)

FSY:	FsymDg_2806

KAL:

KALB_5540

CYA:	CYA_1820(nifV)

CYB:	CYB_0424(nifV)

CYN:	Cyan7425_2367

TSZ:	OOK60_11585(nifV)

LET:	O77CONTIG1_04713(leuA_4)

LBO:	LBWT_23140

LSC:	KIK02_24560(nifV)

LSK:	J5X98_14365(nifV)

PSEU:

Pse7367_2223

PSER:

ABRG53_d046(nifV)

PGX:	OA858_05225(nifV)

THEU:

HPC62_11700(nifV)

TSIN:

OXH18_14600(nifV)

HAO:	PCC7418_1777

ENN:	FRE64_02085(nifV)

CYU:	UCYN_06080

CYT:	cce_0549(nifV)

CWA:	CwatDRAFT_3845

CYP:	PCC8801_1776

CYH:	Cyan8802_1804

CYC:	PCC7424_0947 PCC7424_2127

CYJ:	Cyan7822_1791 Cyan7822_3668

PPSU:

NO713_02601(nifV1)

MPRO:

BJP34_16110

PHOR:

JWS08_14995(nifV)

PYH:	NEA10_16890(nifV)

MIC:	Mic7113_1300

ANA:	alr1407(nifV1) alr2968(nifV2)

NPU:	Npun_F0430

NOS:	Nos7107_0175 Nos7107_3310

NOP:	Nos7524_2286 Nos7524_5258

NON:	NOS3756_17300(aksA_1) NOS3756_18600(aksA_2)

NFL:	COO91_05479 COO91_05563

NOE:	CLI64_00215(nifV) CLI64_05360(nifV)

NSH:

GXM_00779

NED:	HUN01_22765(nifV) HUN01_23180(lysS)

NPZ:	ACX27_17150(aksA)

AVA:	Ava_0938 Ava_3956 Ava_4041

NAZ:

Aazo_1372

ANB:	ANA_C10898(nifV)

ACY:	Anacy_0218

AWA:	AA650_19225(aksA)

ANN:	EH233_02680(nifV) EH233_03410(nifV) EH233_18315(nifV)

CSG:	Cylst_5393

RSIN:

B6N60_04441

HBQ:	QI031_03280(nifV)

CALO:

Cal7507_0055 Cal7507_3999

CALT:

Cal6303_1160

CALH:

IJ00_25035(aksA)

CALN:

NIES2098_35600 NIES2098_42590

CALS:

NIES3974_45360

RIV:	Riv7116_6370

FIS:	FIS3754_34880

NSP:	BMF81_03733(nifV)

NSPH:

BDGGKGIB_00194(leuA_1) BDGGKGIB_00937(leuA_2)

DOU:	BMF77_04749(leuA_3)

DFS:	HGD76_20270(nifV)

DHT:	NG743_06580(nifV)

CCUR:

IAR63_11665

AFLO:

HEQ12_09385(nifV)

STOQ:

K2F26_20825(nifV)

AEE:	IM676_16795(nifV) IM676_16935(nifV)

TOQ:	HCG51_06030(nifV)

ALAX:

NIES50_00100 NIES50_36980 NIES50_47320(aksA)

NCN:	BZZ01_06000 BZZ01_19685 BZZ01_20300

CTHE:

Chro_4594

PLP:	Ple7327_3518

GCY:	LQF76_06440(nifV)

CEO:	ETSB_1480(aksA)

CER:	RGRSB_1535(aksA)

CEEC:

P3F56_07520(nifV)

CAU:

Caur_0328

CHL:	Chy400_0353

CAG:

Cagg_3603

HAU:

Haur_3301

LEK:	hrd7_27850

CAP:	CLDAP_04770

KBS:	EPA93_38780

KBB:	ccbrp13_35950

THUG:

KNN16_06535(lysS)

TTR:

Tter_2761

PMET:

G4Y79_18420(lysS)

DRA:

DR_1238

DGE:

Dgeo_1257

DDR:	Deide_13980

DMR:	Deima_1358

DGO:	DGo_CA1416

DPD:	Deipe_2766

DSW:	QR90_11530

DCH:	SY84_02355

DAB:	AUC44_09460

DPU:	SU48_09295

DEZ:	DKM44_08475(lysS)

DWU:	DVJ83_05005(lysS)

DFC:

DFI_09345

DEIN:

DAAJ005_07905(lysS)

DGA:	DEGR_18060

DPH:	EHF33_05040(lysS)

DRB:	N0D28_09395(lysS)

DAH:	DAETH_17180

DAQU:

M8445_11600(lysS)

DTAE:

LAJ19_07725(lysS)

DMB:	E5F05_12480(lysS)

TRA:

Trad_1388

TTH:

TT_C1550

TTJ:	TTHA1914(TTHA1914)

TTS:	Ththe16_1914

TTL:	TtJL18_1996

TSC:	TSC_c01850(lysS1)

THC:	TCCBUS3UF1_21080

TOS:	Theos_1940

TAQ:

TO73_0091

TBC:	A0O31_00877

TANT:

KNN15_05095(lysS)

MRB:

Mrub_2729

MRE:	K649_08890

MTAI:

Mtai_v1c23280

MSV:	Mesil_0445

OPR:	Ocepr_1779

MHD:	Marky_0673

TNR:	Thena_0289 Thena_0491

TACI:

TDSAC_0283 TDSAC_0468

OBT:	OPIT5_01810 OPIT5_29700

CAA:

Caka_2831

RUFI:

K0V07_13835

MIN:	Minf_1877(leuA)

MKC:

kam1_429

MFH:	MFUM_0528(nifV)

MCAO:

IT6_04235

MEAP:

MTHMO_1013(nifV)

VBS:	EGM51_10175

CCOP:

Mal65_24270(leuA_1)

SSM:	Spirs_3010

STA:	STHERM_c03410

SPER:

EW093_07685

OCK:	EXM22_15160

SCOR:

J3U87_19125(lysS)

IPO:	Ilyop_1399

APS:

CFPG_473

PPN:	Palpr_1434

DRC:	G0Q07_05260

MCOS:

GM418_15715

ASX:	CDL62_03355

MBAS:

ALGA_0874

CGLE:

NCTC11432_00583(leuA_1)

CTE:	CT1528(nifV)

CPC:

Cpar_1614

CLZ:	BIU88_03135

CCH:

Cag_1229

CPH:	Cpha266_1918

CPB:	Cphamn1_1747

CLI:

Clim_0690

PVI:

Cvib_1341

PLT:

Plut_1526

PPH:

Ppha_1919

PAA:

Paes_1624

PROC:

Ptc2401_01787(leuA_4)

PRS:	B9H02_03590

PROS:

CHL67_07880

PROW:

OO006_03830

PROI:

OO005_03715

CTS:

Ctha_1654

HTH:

HTH_1130

HTE:	Hydth_1122

TAL:

Thal_0418

TTA:	Theth_0203

PMO:

Pmob_1703

DTN:	DTL3_1459(leuA2)

DIN:	Selin_2077

DAP:	Dacet_1054

GTL:	EP073_06030(nifV)

CNI:	Calni_0672

DTH:	DICTH_1519(nifV)

DTU:

Dtur_1629

LFC:

LFE_2422

LFP:	Y981_08930(aksA)

MJA:

MJ_0503

MFE:	Mefer_0710

MVU:	Metvu_1576

MFS:	MFS40622_1791

MIF:	Metin_1354

MJH:	JH146_1425

MESG:

MLAUSG7_0108(aksA)

MESA:

MLASG1_1291(aksA)

MIG:	Metig_0696

MMP:	MMP0153(aksA)

MMQ:	MmarC5_1522

MMX:	MmarC6_0797

MMZ:	MmarC7_1153

MMD:	GYY_00785(aksA)

MMAK:

MMKA1_01580(cimA)

MMAO:

MMOS7_01840(cimA)

MMAD:

MMJJ_09310(leuA_1)

MAE:

Maeo_0994

MVN:	Mevan_1158

MVO:

Mvol_1568

MOK:	Metok_0640

METF:

CFE53_04770(aksA)

MTH:

MTH_1630

MMG:	MTBMA_c02150(leuA2)

MWO:	MWSIV6_0176(aksA)

MTEE:

MTTB_13800(aksA)

METC:

MTCT_1489

METE:

tca_01580(leuA_3)

METZ:

METMT2_1469

METK:

FVF72_03475

MTHM:

FZP57_00770

METJ:

FZP68_05780

MST:	Msp_1099(leuA2)

METB:

AW729_10320(aksA)

MEIS:

PXD04_02110

MRU:	mru_0385(aksA)

MSI:

Msm_0722

MEB:	Abm4_0181(aksA)

MMIL:

sm9_2160(aksA)

MEYE:

TL18_01070(aksA)

MOL:

YLM1_0056

MARO:

MarbSA_09070(aksA_1) MarbSA_13810(aksA_2)

METV:

K4897_04155

MEL:	Metbo_2071

MEW:	MSWAN_0569

METH:

MBMB1_0290(aksA)

MFC:	BRM9_1985(aksA)

MFI:	DSM1535_0177(aksA)

MCUB:

MCBB_0566(aksA)

MSUB:

BK009_11615(aksA)

METN:

BK008_07190(aksA)

METT:

CIT01_06835(aksA)

METO:

CIT02_05435(aksA)

MEME:

HYG87_07555

MFEG:

GCM10025860_11500(aksA)

MFV:

Mfer_0964

MKA:	MK1209(leuA)

MBA:	Mbar_A2192 Mbar_A2268 Mbar_A2269

MBY:	MSBRM_1356 MSBRM_1357 MSBRM_2239

MBW:	MSBRW_2477 MSBRW_2478 MSBRW_2549

MBAR:

MSBR2_0170 MSBR2_1052 MSBR2_1053

MBAK:

MSBR3_1047

MAC:	MA_1225(nifV) MA_1226(nifV) MA_3342(leuA)

MMA:

MM_2785

MMAZ:

MmTuc01_2834

MMJ:	MSMAS_1942

MMAC:

MSMAC_1183

MVC:	MSVAZ_2030

MEK:	MSKOL_2008 MSKOL_2218 MSKOL_2219

MLS:	MSLAZ_1553

METM:

MSMTP_1363

MEF:	MSWH1_1527

MEQ:	MSWHS_1780

MSJ:	MSSAC_2553

MSZ:	MSSIH_2157 MSSIH_2896 MSSIH_2897

MSW:	MSSIT_2270 MSSIT_2940 MSSIT_2941

MTHR:

MSTHT_0432

MTHE:

MSTHC_0289

MHOR:

MSHOH_1618

MFZ:	AOB57_000055(aksA)

MBU:	Mbur_0854(cimA)

MMET:

MCMEM_0986

MELO:

J7W08_02750(aksA)

MMH:

Mmah_1162

MHAZ:

BHR79_07725(aksA)

MPOT:

BKM01_03970(aksA)

MEV:	Metev_0432

MZH:	Mzhil_1141

MPY:

Mpsy_2899

MZI:	HWN40_08205(aksA)

MMAV:

RE476_02105

MSEB:

RE474_12000

MHZ:	Metho_0886

MEHF:

MmiHf6_03460(leuA_1)

MEES:

MmiEs2_06200(leuA_1)

MTP:

Mthe_1533

MCJ:	MCON_2596(leuA)

MHI:

Mhar_1932

MHU:

Mhun_1801

MRTJ:

KHC33_05405

MLA:

Mlab_0232

MEM:	Memar_0633

MBG:	BN140_1718(aksA)

MEMA:

MMAB1_2210(aksA)

MCHK:

MchiMG62_07630(aksA)

MSUM:

OH143_09885

MRC:	R6Y96_02550

MPI:

Mpet_2488

MEND:

L6E24_09230

MEFW:

F1737_00615(aksA)

MAQE:

RJ40_05985(aksA)

MFK:	E2N92_06115(aksA)

MOU:	OU421_03650

MESB:

L1S32_07250

MANQ:

L1994_01090

MBN:

Mboo_0598

MFO:	Metfor_2593

MPL:

Mpal_2142

MPD:	MCP_1960(aksA)

MEZ:	Mtc_1560(aksA)

RCI:	RCIX2647(leuA-4)

HASV:

SVXHr_0597(leuA)

HABN:

HBNXHr_0575(leuA)

TAR:	TALC_00557

MAX:	MMALV_05060

MEAR:

Mpt1_c02550(cimA)

MEUZ:

KRP56_01640 KRP56_02715(nifV)

» show all

Reference

1 [PMID:5836514]

Authors

Strassman M, Ceci LN.

Title

Enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis.

Journal

Biochem Biophys Res Commun 14:262-7 (1964)
DOI:10.1016/0006-291X(64)90446-2

Reference

2 [PMID:12095615]

Authors

Wulandari AP, Miyazaki J, Kobashi N, Nishiyama M, Hoshino T, Yamane H.

Title

Characterization of bacterial homocitrate synthase involved in lysine biosynthesis.

Journal

FEBS Lett 522:35-40 (2002)
DOI:10.1016/S0014-5793(02)02877-6

Reference

3 [PMID:15362863]

Authors

Andi B, West AH, Cook PF.

Title

Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.

Journal

Biochemistry 43:11790-5 (2004)
DOI:10.1021/bi048766p

Other DBs

ExplorEnz - The Enzyme Database:

2.3.3.14

IUBMB Enzyme Nomenclature:

2.3.3.14

ExPASy - ENZYME nomenclature database:

2.3.3.14

BRENDA, the Enzyme Database:

2.3.3.14

CAS:

9075-60-9

DBGET integrated database retrieval system