KEGG ENZYME: 2.3.3.19

ENZYME: 2.3.3.19

Entry

EC 2.3.3.19                 Enzyme

Name

2-phosphonomethylmalate synthase;
2-phosphinomethylmalic acid synthase;
PMM synthase

Class

Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer

Sysname

acetyl-CoA:3-phosphonopyruvate C-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + H2O + 3-phosphonopyruvate = (R)-2-(phosphonomethyl)malate + CoA [RN:R11708]

Reaction(KEGG)

R11708

Substrate

acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
3-phosphonopyruvate [CPD:C02798]

Product

(R)-2-(phosphonomethyl)malate [CPD:C21613];
CoA [CPD:C00010]

Comment

The enzyme, isolated from several Streptomyces species, participate in the biosynthesis of certain phosphonate antibiotics. The enzyme is analogous to EC 2.3.3.1 (Si)-citrate synthase.

History

EC 2.3.3.19 created 2017

Pathway

ec00440

Phosphonate and phosphinate metabolism

Orthology

K21934

2-phosphonomethylmalate synthase

Reference

1 [PMID:3781934]

Authors

Shimotohno K, Seto H, Otake N, Imai S, Satoh A

Title

Studies on the biosynthesis of bialaphos (SE-1293). 7. The absolute configuration of 2-phosphinomethylmalic acid, a biosynthetic intermediate of bialaphos.

Journal

J Antibiot (Tokyo) 39:1356-9 (1986)
DOI:10.7164/antibiotics.39.1356

Reference

2 [PMID:3170341]

Authors

Shimotohno KW, Seto H, Otake N, Imai S, Murakami T

Title

Studies on the biosynthesis of bialaphos (SF-1293). 8. Purification and characterization of 2-phosphinomethylmalic acid synthase from Streptomyces hygroscopicus SF-1293.

Journal

J Antibiot (Tokyo) 41:1057-65 (1988)
DOI:10.7164/antibiotics.41.1057

Reference

3 [PMID:18721747]

Authors

Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW

Title

Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.

Journal

Chem Biol 15:765-70 (2008)
DOI:10.1016/j.chembiol.2008.07.010

Sequence

[ag:ABB90392]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.3.19

IUBMB Enzyme Nomenclature:

2.3.3.19

ExPASy - ENZYME nomenclature database:

2.3.3.19

BRENDA, the Enzyme Database:

2.3.3.19

DBGET integrated database retrieval system