Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy

acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate [RN:R07399]

R07399
Reaction

acetyl-CoA [CPD:C00024];
pyruvate [CPD:C00022];
H2O [CPD:C00001]

One of the enzymes involved in a pyruvate-derived pathway for isoleucine biosynthesis that is found in some bacterial and archaeal species [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2].

EC 2.3.3.21 created 2007 as EC 2.3.1.182, transferred 2021 to EC 2.3.3.21

1  [PMID:9864346]

2  [PMID:15292141]