| Entry |
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| Name |
2-ethylmalate synthase;
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating);
2-ethylmalate-3-hydroxybutanedioate synthase;
propylmalate synthase;
propylmalic synthase
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| Class |
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
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| Sysname |
acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
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| Reaction(IUBMB) |
acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA [RN: R00998]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase.
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| History |
EC 2.3.3.6 created 1983 as EC 4.1.3.33, transferred 2002 to EC 2.3.3.6
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| Pathway |
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| Reference |
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| Authors |
Strassman M, Ceci LN. |
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| Title |
A study of acetyl-CoA condensation with alpha-keto acids. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.3.3.6 |
| ExPASy - ENZYME nomenclature database: | 2.3.3.6 |
| BRENDA, the Enzyme Database: | 2.3.3.6 |
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