Entry
Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I;
beta6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase;
core 2 acetylglucosaminyltransferase;
core 6-beta-GlcNAc-transferase A;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase;
GCNT1;
GCNT3;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein] = UDP + O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:
R04575 R05912 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
Product
UDP [CPD:
C00015 ];
O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
History
EC 2.4.1.102 created 1983, modified 2018
Pathway
ec00512 Mucin type O-glycan biosynthesis
Orthology
K00727 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Genes
MMUR : 105862366 105868687(GCNT1)
AAMP : 119820782(Gcnt1) 119826209
OPI : 101519978 101535946(GCNT1)
HHV : 120225185 120238445(GCNT1)
CCAD : 122420261 122452853(GCNT1)
SCAM : 104142803(GCNT1) 104152056
XLA : 380501(gcnt1.L) 495090(gcnt1.S)
TFD : 113645913 113656276 113657001
TVC : 132853817(sb:cb288) 132853829
AMEX : 103024919(gcnt1) 111189883
ALAT : 119019681 119020259 119020260
MZE : 101481222 101481511 101485293 112435648
ONL : 100695077 100695236 100695500 100711034 102079779 109194425 109201782 109204432
OAU : 116311867 116311880 116313061 116332432 116332433 116332434 120443083 120443084
CSAI : 133443735 133451078
CTUL : 119781520 119797394
NFU : 107394005 107394006 107394008
ALIM : 106523800 106523801
AOCE : 111575565 111576639
MCEP : 125011747 125012221
HHIP : 117768421 117768422
HSP : 118114916 118114917 118114918 118114919
PSPA : 121318921 121318929 121328228
ARUT : 117408409 117420839 117420920
PMRN : 116938306 116941023 116941032 116957641 116957644 116958536
LRJ : 133346773 133346774 133360520 133360524 133360684 133360685
LPIC : 129282372 129282432
SKO : 100372443 100372744 100373957 100375210 100379011
CEL : CELE_C54C8.11(gly-15) CELE_T15D6.2(gly-16)
CBR : CBG_04363(Cbr-gly-15)
NAI : NECAME_01847 NECAME_07494
HRO : HELRODRAFT_106314 HELRODRAFT_141556 HELRODRAFT_72329
LGI : LOTGIDRAFT_104647 LOTGIDRAFT_108047 LOTGIDRAFT_163866 LOTGIDRAFT_54803 LOTGIDRAFT_73452
PVUL : 126808488 126809906 126811416 126811876 126812228 126812232 126812233 126812234 126816455 126824250 126829367 126830488 126830667 130013131
PCAN : 112553289 112553290 112554440 112561191 112562773 112562774 112562775 112568345 112568760 112568761 112568762 112568892 112570429 112571042 112574428 112575127
BGT : 106051358 106054203 106058043 106061498 106066663 106068870 106068871 106071886
GAE : 121366709 121375905 121376305 121378076 121378859 121378861 121378902 121379313 121384333 121385720 121385928 121386880 121389643 121391132
HRF : 124119522 124119524 124120096 124120233 124120235 124120248 124120253 124121808 124123113 124125089 124132696 124142190 124148336 124150987 124152028
HRJ : 124253757 124254618 124254619 124257643 124257644 124257647 124257669 124261325 124265796 124279184 124280091 124286439 124286440 124286577 124289654
CRG : 105320752 105334548 105335887 105336571 105336746 105336756 105343968 109619687 117685721 117685722 117685724 117685725 117685726 117691383 117691384 117691474
CVN : 111103731 111104928 111106297 111108249 111109201 111110747 111111947 111115897 111119853 111123692 111125443 111127407 111129668 111133556 111134071 111136299 111136324
CANU : 128155415 128157006 128157257 128164074 128183731 128183732 128183733 128183734 128183744 128185086 128185692 128185699 128185775 128188668 128188836
OED : 125656518 125668000 125668002 125668005 125668006 125669209 125669210 125669540 125670166 125673641 125680532 125681942
MYI : 110445188 110449075 110455573 110456784 110458069 110465295
PMAX : 117330518 117332605 117333071 117340932 117341076 117341501
MMER : 123524577 123527992 123532558 123532716 123535190 123541568 123549078 123551880 123557471 123558470 123561080 123561083 123561972 123562903 123562913 123563217 123563220 123563222 123563223 123564464 123564465
RPHI : 132715876 132716057 132720573 132724922 132725045 132725046 132725049 132725576 132725741 132725743 132725745 132728453 132730284 132736478 132741414 132741948 132744750 132744751 132744752 132744761 132745982 132746252 132747786 132757546 132758129 132758130 132759380 132759808 132759813
DPOL : 127838254 127846593 127853455 127853536 127854117 127857464 127858754 127858755 127858756 127862719 127867418 127867419 127867423 127867424 127870381 127871414 127873624 127881259 127881260 127881266 127881267 127881386
OBI : 106868699 106873990 106881820 106881829 106883007
OSN : 115212411 115216648 115216679 115216680 115220830 115220835 115222617 115223487
LAK : 106150782 106155088 106155707 106155709 106174181 106181126
SMM : Smp_009810 Smp_154680
» show all
Taxonomy
Reference
Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
Journal
Reference
Authors
Williams D, Longmore G, Matta KL, Schachter H.
Title
Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase.
Journal
J Biol Chem 255:11253-61 (1980)
Reference
Authors
Williams D, Schachter H.
Title
Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.
Journal
J Biol Chem 255:11247-52 (1980)
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.102