KEGG   ENZYME: 2.4.1.110
Entry
EC 2.4.1.110                Enzyme                                 
Name
tRNA-queuosine alpha-mannosyltransferase;
GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase (incorrect);
tRNA-queuosine beta-mannosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:queuosine34 in tRNAAsp O-4''-alpha-D-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + queuosine34 in tRNAAsp = GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp [RN:R04082]
Reaction(KEGG)
R04082
Substrate
GDP-alpha-D-mannose [CPD:C00096];
queuosine34 in tRNAAsp
Product
GDP [CPD:C00035];
O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp
Comment
This enzyme, found in higher vertebrates, modifies tRNAAsp at the wobble position of the anticodon loop.
History
EC 2.4.1.110 created 1984, modified 2022
Reference
1  [PMID:20603]
  Authors
Okada N, Nishimura S.
  Title
Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver.
  Journal
Nucleic Acids Res 4:2931-8 (1977)
DOI:10.1093/nar/4.8.2931
Reference
2  [PMID:34880214]
  Authors
Hillmeier M, Wagner M, Ensfelder T, Korytiakova E, Thumbs P, Muller M, Carell T.
  Title
Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine.
  Journal
Nat Commun 12:7123 (2021)
DOI:10.1038/s41467-021-27371-9
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.110
IUBMB Enzyme Nomenclature: 2.4.1.110
ExPASy - ENZYME nomenclature database: 2.4.1.110
BRENDA, the Enzyme Database: 2.4.1.110
CAS: 9055-06-5

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (18)   
   UniProt (9)   
   SWISS-PROT (9)   
Protein domain (3)   
   InterPro (3)   
All databases (28)   

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