KEGG ENZYME: 2.4.1.134

ENZYME: 2.4.1.134

Entry

EC 2.4.1.134                Enzyme

Name

galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting)

Reaction(IUBMB)

UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05927]

Reaction(KEGG)

R05927(G)

Substrate

UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine

Product

UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:C04825]

Comment

Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.

History

EC 2.4.1.134 created 1984, modified 2002

Pathway

ec00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

ec00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

ec01100

Metabolic pathways

Orthology

K00734

galactosylxylosylprotein 3-beta-galactosyltransferase

Genes

HSA:	126792(B3GALT6)

PTR:	457187(B3GALT6)

PPS:	100971409(B3GALT6)

PON:	112135480(B3GALT6)

NLE:	115833053(B3GALT6)

HMH:	116812768(B3GALT6)

MCC:	703713(B3GALT6)

MCF:	102115188(B3GALT6)

MTHB:

126952061

MNI:	105498306(B3GALT6)

CSAB:

103225816(B3GALT6)

CATY:

105572458(B3GALT6)

PANU:

101003310(B3GALT6)

TGE:	112625398(B3GALT6)

RRO:	104673226(B3GALT6)

RBB:	108544195(B3GALT6)

TFN:	117093480(B3GALT6)

PTEH:

111526850(B3GALT6)

CJC:	100387131(B3GALT6)

CIMI:

108313919(B3GALT6)

CSYR:

103250094(B3GALT6)

MMUR:

105877638(B3GALT6)

LCAT:

123636029(B3GALT6)

PCOQ:

105820907(B3GALT6)

OGA:	100958919(B3GALT6)

MMU:	117592(B3galt6)

MCAL:

110292468(B3galt6)

MPAH:

110322882(B3galt6)

RNO:	298690(B3galt6)

MCOC:

116097170(B3galt6)

ANU:	117708571(B3galt6)

MUN:	110560227(B3galt6)

CGE:	100767598(B3galt6)

MAUA:

101833181(B3galt6)

PROB:

127213542(B3galt6)

PLEU:

114708248(B3galt6)

MORG:

121443545 121448529(B3galt6)

MFOT:

126493175

AAMP:

119816893(B3galt6)

NGI:	103749737(B3galt6)

HGL:	101721217(B3galt6)

CPOC:

100730778(B3galt6)

CCAN:

109681028(B3galt6)

DORD:

106002935(B3galt6)

DSP:	122127349(B3galt6)

PLOP:

125354206(B3galt6)

NCAR:

124963718

MMMA:

107155460(B3galt6)

OCU:	103351814 127489283

OPI:	101521287(B3GALT6)

TUP:	102502785(B3GALT6)

CFA:	664717(B3GALT6)

CLUD:

112647021(B3GALT6)

VVP:	112926057(B3GALT6)

VLG:	121500774(B3GALT6)

NPO:	129496555(B3GALT6)

AML:	100473227(B3GALT6)

UMR:	103682080(B3GALT6)

UAH:	113270686(B3GALT6)

UAR:	123796089(B3GALT6)

ELK:

111154922

LLV:

125097488

MPUF:

101677593(B3GALT6)

MNP:	132001037(B3GALT6)

MLK:	131810351(B3GALT6)

NVS:	122899323(B3GALT6)

ORO:	101364618(B3GALT6)

EJU:	114213404(B3GALT6)

ZCA:	113928681(B3GALT6)

MLX:	118020133(B3GALT6)

NSU:	110575332(B3GALT6)

FCA:	105259949(B3GALT6)

PYU:	121017977(B3GALT6)

PCOO:

112864860(B3GALT6)

PBG:	122479773(B3GALT6)

LRUF:

124514991

PTG:	102964488(B3GALT6)

PPAD:

109273914(B3GALT6)

PUC:

125913244

AJU:	106978137 113599162

HHV:	120242505(B3GALT6)

BTA:	522406(B3GALT6)

BOM:	102265005(B3GALT6)

BIU:	109570568(B3GALT6)

BBUB:

102406953(B3GALT6)

BBIS:

104996102(B3GALT6)

CHX:	102191357(B3GALT6)

OAS:	101105768(B3GALT6)

BTAX:

128061558(B3GALT6)

ODA:	120862075 120880627(B3GALT6)

CCAD:

122452078(B3GALT6)

MBEZ:

129551405(B3GALT6)

SSC:	100523125(B3GALT6)

CFR:	102522264(B3GALT6)

CBAI:

105071076(B3GALT6)

CDK:	105105583(B3GALT6)

LVE:	103085660(B3GALT6)

OOR:	101276763(B3GALT6)

DLE:	111187245(B3GALT6)

PCAD:

112065327(B3GALT6)

PSIU:

116756707(B3GALT6)

ECB:	100146417(B3GALT6)

EPZ:	103558570(B3GALT6)

EAI:	106845197(B3GALT6)

MMYO:

118655568(B3GALT6)

PKL:	118731977(B3GALT6)

EFUS:

103295354(B3GALT6)

MNA:	107543692(B3GALT6)

DRO:	112299603(B3GALT6)

SHON:

118998221(B3GALT6)

AJM:	119050524(B3GALT6)

PDIC:

114497174(B3GALT6)

PHAS:

123831877(B3GALT6)

MMF:	118643408(B3GALT6)

PPAM:

129079267(B3GALT6)

HAI:	109391146(B3GALT6)

RFQ:	117026943(B3GALT6)

PALE:

102879449(B3GALT6)

PGIG:

120614084(B3GALT6)

RAY:	107503893 107510710(B3GALT6)

MJV:	108409072(B3GALT6)

TOD:	119236531(B3GALT6)

SARA:

101551557(B3GALT6)

LAV:	100659349(B3GALT6)

TMU:

101342110

ETF:	101640488(B3GALT6)

DNM:	101412993(B3GALT6)

MDO:	100024991(B3GALT6)

GAS:	123240111(B3GALT6)

SHR:	116422871(B3GALT6)

AFZ:

127556024

PCW:	110201068(B3GALT6)

OAA:	100074836(B3GALT6)

GGA:	428185(B3GALT6)

PCOC:

116242558(B3GALT6)

MGP:	104914138(B3GALT6)

CJO:	107323501(B3GALT6)

TPAI:

128085037(B3GALT6)

LMUT:

125703417(B3GALT6)

NMEL:

110408704(B3GALT6)

APLA:

101798225(B3GALT6)

ACYG:

106044272(B3GALT6)

CATA:

118253261(B3GALT6)

AFUL:

116497597(B3GALT6)

TGU:	100225099(B3GALT6)

LSR:	110474385(B3GALT6)

SCAN:

103820901(B3GALT6)

PMOA:

120511127(B3GALT6)

OTC:	121344105(B3GALT6)

PRUF:

121358335(B3GALT6) 121358342

FAB:	101808759(B3GALT6)

OMA:	130261658(B3GALT6)

PHI:	102108353(B3GALT6)

PMAJ:

107213734(B3GALT6)

CCAE:

111938482(B3GALT6)

CCW:	104693401(B3GALT6)

CBRC:

103622302(B3GALT6)

ETL:	114071242(B3GALT6)

ZAB:	102062738(B3GALT6)

ACHL:

103809603(B3GALT6)

SVG:	106858906(B3GALT6)

MMEA:

130588631(B3GALT6)

HRT:	120762285(B3GALT6)

FPG:	101913380(B3GALT6)

FCH:	102056999(B3GALT6)

CLV:	102096830(B3GALT6)

EGZ:	104133398(B3GALT6)

NNI:	104009059(B3GALT6)

PCRI:

104023992(B3GALT6)

PLET:

104620975(B3GALT6)

EHS:	104508150(B3GALT6)

PCAO:

104047856(B3GALT6)

ACUN:

113487982(B3GALT6)

TALA:

104355594(B3GALT6)

PADL:

103918023(B3GALT6)

AFOR:

103894783(B3GALT6)

ACHC:

115343036(B3GALT6)

HALD:

104312985(B3GALT6)

HLE:	104837931(B3GALT6)

AGEN:

126041894

GCL:

127024687

CCRI:

104154611(B3GALT6)

CSTI:

104562399(B3GALT6)

CMAC:

104479565(B3GALT6)

MUI:	104534116(B3GALT6)

BREG:

104642472(B3GALT6)

FGA:	104074823(B3GALT6)

GSTE:

104263956(B3GALT6)

LDI:	104339978(B3GALT6)

MNB:	103779504(B3GALT6)

OHA:	104336061(B3GALT6)

NNT:	104403522(B3GALT6)

SHAB:

115617565(B3GALT6)

DPUB:

104305940(B3GALT6)

PGUU:

104469478(B3GALT6)

ACAR:

104520744(B3GALT6)

CPEA:

104395466(B3GALT6)

AVIT:

104279118(B3GALT6)

CVF:	104290552(B3GALT6)

RTD:	128918509(B3GALT6)

CUCA:

104055619(B3GALT6)

TEO:	104372719(B3GALT6)

BRHI:

104496585(B3GALT6)

AAM:	106495555(B3GALT6)

AROW:

112970105(B3GALT6)

NPD:	112957393(B3GALT6)

TGT:	104569274(B3GALT6)

DNE:	112983500(B3GALT6)

SCAM:

104141997(B3GALT6)

ASN:	102373206(B3GALT6)

AMJ:	102571760(B3GALT6)

CPOO:

109314423(B3GALT6)

GGN:	109293554(B3GALT6)

PSS:	102452076(B3GALT6)

CMY:	102942046(B3GALT6)

CCAY:

125624374(B3GALT6)

DCC:	119845163(B3GALT6)

CPIC:

101943011(B3GALT6)

TST:	117867974(B3GALT6)

CABI:

116824600(B3GALT6)

MRV:	120387825(B3GALT6)

ASAO:

132764837(B3GALT6)

PVT:	110073136(B3GALT6)

SUND:

121937204(B3GALT6)

PBI:	103049964(B3GALT6)

PMUR:

107298347(B3GALT6)

CTIG:

120318999(B3GALT6)

TSR:	106541052(B3GALT6)

PGUT:

117675860(B3GALT6)

APRI:

131187139(B3GALT6)

PTEX:

113446182(B3GALT6)

NSS:	113421288(B3GALT6)

VKO:	123030942(B3GALT6)

PMUA:

114602507(B3GALT6)

PRAF:

128419734(B3GALT6)

ZVI:	118087931(B3GALT6)

HCG:	128338695(B3GALT6)

GJA:	107110843(B3GALT6)

STOW:

125445691(B3GALT6)

EMC:	129344414(B3GALT6)

XLA:	108696563(b3galt6.L) 108697636(b3galt6.S)

XTR:	548849(b3galt6)

NPR:	108784315(B3GALT6)

RTEM:

120915404(B3GALT6)

BBUF:

121004783(B3GALT6)

BGAR:

122926567(B3GALT6)

MUO:	115482650(B3GALT6)

GSH:	117348732(B3GALT6) 117354194

DRE:	572324(b3galt6)

SRX:	107714504 107751019

SANH:

107680432 107699339

SGH:	107555998 107592565

CCAR:

109066899 109098579

CAUA:

113055100 113069397

CGIB:

127968611 128022598

PTET:

122354624(b3galt6)

LROH:

127172694(b3galt6)

OMC:	131549749(b3galt6)

PPRM:

120473396(b3galt6)

RKG:	130071800(b3galt6)

MAMB:

125256819(b3galt6)

CIDE:

127522816

MASI:

127426325 127428241

TROS:

130571219(b3galt6)

TDW:	130410338(b3galt6)

MANU:

129427941(b3galt6)

IPU:

108255271

IFU:	128625233(b3galt6)

PHYP:

113539477(b3galt6)

SMEO:

124402544(b3galt6)

TFD:	113661931(b3galt6)

TVC:	132838247(b3galt6)

AMEX:

103027814(b3galt6)

CMAO:

118799964(b3galt6)

EEE:	113585544(b3galt6)

CHAR:

105898137(b3galt6)

TRU:	777996(b3galt6)

TFS:	130524102(b3galt6)

LCO:	104939272(b3galt6)

NCC:	104942072(b3galt6)

TBEN:

117486501(b3galt6)

CGOB:

115008833(b3galt6)

PGEO:

117447155(b3galt6)

GACU:

117547515(b3galt6)

EMAC:

134883630(b3galt6)

ELY:	117256359(b3galt6)

EFO:	125886969(b3galt6)

PLEP:

121953859(b3galt6)

SLUC:

116067467(b3galt6)

ECRA:

117943739(b3galt6)

ESP:	116687782(b3galt6)

PFLV:

114554241(b3galt6)

GAT:	120835278(b3galt6)

PPUG:

119229718(b3galt6)

AFB:	129105330(b3galt6)

CLUM:

117731223(b3galt6)

PSWI:

130191254(b3galt6)

MSAM:

119886187(b3galt6)

SCHU:

122868234(b3galt6)

CUD:	121529149(b3galt6)

ALAT:

119021203(b3galt6)

MZE:	101485514(b3galt6)

ONL:	100693145(b3galt6)

OAU:	116326550(b3galt6)

OLA:	100049392(b3galt6)

OML:	112145073(b3galt6)

CSAI:

133448814(b3galt6)

XMA:	102230525(b3galt6)

XCO:	114136114(b3galt6)

XHE:	116710500(b3galt6)

PRET:

103464912(b3galt6)

PFOR:

103144356(b3galt6)

PLAI:

106955120(b3galt6)

PMEI:

106917398(b3galt6)

GAF:	122833643(b3galt6)

PPRL:

129356433(b3galt6)

CVG:	107101435(b3galt6)

CTUL:

119791815(b3galt6)

GMU:	124856092(b3galt6)

NFU:	107385557(b3galt6)

KMR:	108246845(b3galt6)

ALIM:

106513334(b3galt6)

NWH:	119411667(b3galt6)

AOCE:

111587882(b3galt6)

MCEP:

125007439(b3galt6)

CSEM:

103386136(b3galt6)

POV:	109629160(b3galt6)

SSEN:

122767632(b3galt6)

HHIP:

117761446(b3galt6)

HSP:	118105344(b3galt6)

SMAU:

118309880(b3galt6)

LCF:

108884066

SDU:	111221818(b3galt6)

SLAL:

111667675(b3galt6)

XGL:	120807316(b3galt6)

HCQ:	109522223(b3galt6)

SSCV:

125977869

SBIA:

133507190(b3galt6)

PEE:	133408663(b3galt6)

PTAO:

133483247(b3galt6)

BPEC:

110165823(b3galt6)

MALB:

109956258(b3galt6)

BSPL:

114856146(b3galt6)

SJO:	128355846(b3galt6)

SASA:

106582684 106593203

STRU:

115151055 115207362

OTW:	112221817 112254159

OMY:	110494759 110527712

OGO:	124002933 124021082

ONE:	115143517 115145326

OKI:	109890807 109899633

OKE:	118388200 118399919

SALP:

111970598 112080947

SNH:	120023840 120064928

CCLU:

121574770(b3galt6)

ELS:	105007424(b3galt6)

SFM:	108938192(b3galt6)

PKI:	111853658(b3galt6)

AANG:

118210577(b3galt6)

LOC:	102694517(b3galt6)

PSPA:

121329263 121329297

ARUT:

117425319 117972756

PSEX:

120530945(b3galt6)

LCM:	102355255(B3GALT6)

CMK:	103187433(b3galt6)

RTP:	109918536(b3galt6)

CPLA:

122540307

HOC:	132833608(b3galt6)

LERI:

129711531(b3galt6)

PMRN:

116946874(B3GALT6)

LRJ:	133351161(B3GALT6)

BFO:	118410806 118411359 118430418

BBEL:

109464793 109466855 109479943

CIN:	778996(b3galt6)

SCLV:

120341313 120341315

SPU:	115921698 115924557 585022 753784

LPIC:

129276301 129276314 129276703

APLC:

110979066 110979076

AJC:

117114774

SKO:

100367674

DME:	Dmel_CG8734(beta3GalTII)

DER:

6543072

DSE:

6608207

DSI:	Dsimw501_GD27981(Dsim_GD27981)

DYA:	Dyak_GE22868(Dyak_beta3galt6)

DAN:

6502488

DSR:

110182817

DPO:

6902748

DPE:

6597933

DMN:

108162389

DWI:

6644411

DGR:

6566393

DMO:	Dmoj_GI17485

DAZ:

108610340

DNV:

115562853

DHE:

111592079

DVI:

6627305

CCAT:

101456591

BOD:

106615736

BDR:

105221813

RZE:	108365364 108374143

AOQ:

129246950

TDA:

119687357

MDE:

101899820

SCAC:

106084399

LCQ:

111679243

LSQ:

119609799

GFS:

119642715

ECOE:

129939432

CLON:

129618606

HIS:

119653093

AGA:

1280132

ACOZ:

120959582

AARA:

120901636

AMER:

121595845

ASTE:

118512538

AFUN:

125763950

AMOU:

128301174

AALI:

118460973

AAG:

5568811

AALB:

109419591

CQU:	CpipJ_CPIJ010407

CPII:

120425909

CNS:

116341215

BCOO:

119078669

AME:

102655877

ACER:

108003457

ALAB:

122711455

ADR:

102680594

AFLR:

100865260

BIM:

100740262

BBIF:

117214488

BVK:

117242628

BVAN:

117161233

BTER:

100644667

BAFF:

126925321

BPYO:

122576443

BPAS:

132914476

FVI:

122527186

CCAL:

108622599

OBB:

114880076

OLG:

117606442

MGEN:

117222654

NMEA:

116425873

CGIG:

122403002 122403764

SOC:

105194992

MPHA:

105829197

AEC:

105155005

ACEP:

105626882

PBAR:

105426350

VEM:

105566820

HST:

105186112

DQU:

106745352

CFO:

105255994

FEX:

115243790

LHU:

105669725

PGC:

109857902

OBO:

105284463

PCF:

106788423

PFUC:

122522484

VPS:

122634692

VCRB:

124430012

VVE:

124954902

NVI:

100680242

CSOL:

105359846

TPRE:

106659421

LHT:

122499156

LBD:

127282005

MDL:

103571274

CGLO:

123261645

FAS:

105270274

DAM:

107035758

AGIF:

122859047

CINS:

118064670

VCAN:

122408940

CCIN:

107266373

DSM:

124409973

NPT:

124217079

NFB:

124180265

NLO:

107220329

NVG:

124303036

AROA:

105687140

TCA:

656431

DPA:

109534754

SOY:

115889543

AGRG:

126736701

ATD:

109599054

CSET:

123311551

AGB:

108910758

LDC:

111509085

NVL:

108563522

APLN:

108735776

PPYR:

116170377

OTU:

111424934

BMOR:

101740645

BMAN:

114247960

MSEX:

115449198

DPL:	KGM_203077

BANY:

112045668

MJU:

123864867

NIQ:

126778792

VCD:

124537227

MCIX:

123664536

PMAC:

106712341

PPOT:

106107973

PXU:

106117241

PRAP:

111001912

PBX:

123717655

PNAP:

125061803

ZCE:

119830168

CCRC:

123700226

LSIN:

126971217

HAW:

110383736

HZE:

124641691

TNL:

113493565

SLIU:

111354696

OFU:

114352165

PXY:

105386738

PGW:

126378464

CCRN:

123293455

API:	100168819 100574538

DNX:

107164501

AGS:	114128883 114128889

RMD:	113556535 113559464

ACOO:

126838762

DVT:

126894137

BTAB:

109035941

DCI:

103514882

CLEC:

106670905

HHAL:

106686435

NLU:

111047956

HVI:

124359504

MQU:

128993435

PHU:	Phum_PHUM361650

FOC:

113218242

TPAL:

117643550

ZNE:

110831323

CSEC:

111867039

SGRE:

126295406 126295408

IEL:

124164070

FCD:

110850766

DPX:	DAPPUDRAFT_65862

DMK:

116916453

DPZ:

124328348

PVM:	113821037 113821051

PJA:

122248394

PCHN:

125029043

PMOO:

119574129

HAME:

121879271

PCLA:

123756098

CQD:

128686351

PTRU:

123517004

ESN:

127000022

HAZT:

108667009

EAF:

111700018

LSM:

121114049

TCF:

131886829

PPOI:

119096713 119097867

DSV:	119446461 119446463

RSAN:

119389641 119389643

RMP:	119180578 119180586

VDE:

111249317

VJA:

111270592

TUT:

107368691

DPTE:

113794377

DFR:

124497317

CSCU:

111625572

PTEP:

107448329

ABRU:

129985196

UDV:

129229567

SDM:

118186131

LPOL:

106473282

CEL:	CELE_Y110A2AL.14(sqv-2)

CBR:	CBG_19617(Cbr-sqv-2)

CRQ:	GCK72_006770

NAI:	NECAME_13336

BMY:	BM_BM7274(Bma-sqv-2)

LOA:	LOAG_03680

HRO:	HELRODRAFT_169080

LGI:	LOTGIDRAFT_125392

PVUL:

126827177

PCAN:

112556227

BGT:

106065403

GAE:

121390616

HRF:

124111204

HRJ:

124265859

CRG:

105340554

CVN:

111138398

CANU:

128189218

OED:

125663861

MYI:

110450118

PMAX:

117344584

MCAF:

127720574

MMER:

123527630

RPHI:

132720046 132756340

DPOL:

127832442

OBI:

106882295

OSN:

115224526

LAK:

106161537

NVE:

5501668

EPA:

110240882

ATEN:

116295325

ADF:

107328872

AMIL:

114971432

PDAM:

113675377

SPIS:

111320722

DGT:

114526059

XEN:

124446513

HMG:

100208936

HSY:

130636358

AQU:	100637620 100640622 105313401 105313426 105316663

PALZ:

118058471

MBR:	MONBRDRAFT_23896

SRE:	PTSG_02498

FCY:	FRACYDRAFT_267815

» show all

Reference

1 [PMID:3924029]

Authors

Robinson JA, Robinson HC.

Title

Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.

Journal

Biochem J 227:805-14 (1985)
DOI:10.1042/bj2270805

Reference

2 [PMID:1150655]

Authors

Schwartz NB, Roden L.

Title

Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.

Journal

J Biol Chem 250:5200-7 (1975)

Reference

3 [PMID:11551958]

Authors

Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD

Title

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).

Journal

J Biol Chem 276:48189-95 (2001)
DOI:10.1074/jbc.M107339200

Sequence

[hsa:126792] [mmu:117592]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.134

IUBMB Enzyme Nomenclature:

2.4.1.134

ExPASy - ENZYME nomenclature database:

2.4.1.134

BRENDA, the Enzyme Database:

2.4.1.134

CAS:	56626-21-2 56626-19-8

DBGET integrated database retrieval system